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Dietary supplement

Bilberry 100 mg Ingredients & Drug Interactions

by Natures Plus Herbal Actives

Bilberry 100 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry 100 mg is a dietary supplement by Natures Plus Herbal Actives with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry 100 mg by Natures Plus Herbal Actives

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry 100 mg by Natures Plus Herbal Actives — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bilberry 100 mg by Natures Plus Herbal Actives

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Bilberry 100 mg is a straightforward single-ingredient supplement—just bilberry fruit extract in a tablet form. The inactive ingredients are standard tablet binders and fillers: di-calcium phosphate, microcrystalline cellulose, magnesium stearate, stearic acid, silica, hydroxypropyl methylcellulose, and pharmaceutical glaze.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bilberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: nutritional support for healthy eye function.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Glaucoma — and 4 related terms.
  • The closest evidence on file: Bilberry is rated "Possibly Ineffective" for Night vision (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Diabetic retinopathy, Dry eye, and more.

The evidence for bilberry is mixed and limited. Night vision is rated possibly ineffective—it doesn't seem to deliver on that common claim.

For age-related cognitive decline, age-related macular degeneration (AMD), atherosclerosis, high cholesterol (hyperlipidemia), and chronic venous insufficiency (a condition where veins don't pump blood back to the heart well), we don't have enough reliable evidence to rate whether bilberry works. If any of those conditions brought you here, talk with your doctor about whether bilberry is worth trying.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit as food is generally well tolerated, but the safety data for supplements at higher doses is limited. The most common side effects from taking it orally are dark-colored stools, flatulence, and digestive discomfort.

In a few studies, mild flatulence showed up in about a third of patients (though those had ulcerative colitis, which complicates the picture), and temporary GI upset in about 13% of others. Your stools, tongue, and possibly teeth may turn dark bluish or black—that's harmless but worth knowing.

Bilberry is rated likely safe in pregnancy and lactation, so if you're pregnant or breastfeeding, it's not ruled out; still, check with your doctor or pharmacist first since long-term supplement safety data are thin.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—bilberry may increase bleeding risk. Also flag it if you take diabetes medications, since bilberry might lower blood sugar too much.

If you're on erlotinib (a cancer drug) or any medications broken down by the CYP2E1 liver enzyme, mention this supplement as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bilberry might appeal to you if you're interested in eye or cognitive health, but the evidence is weak or absent for most of those uses. If you take blood thinners, diabetes drugs, or erlotinib, you'll want to clear this with your doctor or pharmacist before starting.

Otherwise, it's generally well tolerated—just expect the possibility of darker stools and some GI fussiness. Talk it over with your own healthcare provider to decide whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry 100 mg, straight from the product label.

Brand Natures Plus Herbal Actives
Barcode (UPC) 097467073104
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Dec 23, 2016
DSLD ID 68973
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry 100 mg by Natures Plus Herbal Actives, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Extended Release Tablet(s)
Maximum serving Sizes:
1 Extended Release Tablet(s)
UPC/BARCODE
097467073104
IngredientAmount% DV
Bilberry100 mg--

Other ingredients: Di-Calcium Phosphate, Stearic Acid, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nutritional Support for Healthy Eye Function.

Each Herbal Actives extended-release formula provides rapid and sustained results.

This is not a prescription product. It is a dietary supplement made with the highest possible quality standards.

Prescription quality

Extended release

Guaranteed Maximum Potency: Each Herbal Actives formula is scientifically standardized to the highest level of active principles. HerbaShield: An exclusive purity and safety system providing light-resistant bottle, airtight inner seal, moisture-absorbing packet, tamper-evident safety cap and tamper-proof full bottle seal.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement offering the consistent benefits of exact potency, one tablet daily or as recommended by your health care professional.

Precautions

Note: If you are pregnant or nursing, consult your health care professional before using any herbal product.

Printed HerbaShield inner seal and full bottle seal. Do not use if either seal is missing or broken.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

HerbaShield

Herbal Actives is a registered trademark of Natural Organics, Inc. in the US and/or other countries.

Natural Organics

FDA Statement of Identity

Standardized Botanical Supplement

Seals/Symbols

Maximum guaranteed potency

Gluten free

Formulation

Vegetarian

Free from artificial colors and preservatives. Free from the common allergens yeast, wheat, soy and milk.

Gluten free

Formula

Hypo-allergenic

25% Anthocyanosides

Supplying the greatest concentration of active botanical principles, Herbal Actives Bilberry maximizes the synergistic benefits of the whole fruit.

Storage

Keep tightly closed in a cool, dry place.

General

Product No. 7310 LBL. 1136668

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry 100 mg by Natures Plus Herbal Actives label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry 100 mg by Natures Plus Herbal Actives

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Extended Release Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Bilberry

Interacts with
275 drugs
100 mg per serving Form: Anthocyanosides

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry monograph & interactions

Other (inactive) ingredients: Di-Calcium Phosphate, Stearic Acid, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry 100 mg by Natures Plus Herbal Actives Drug Interactions

Want to check YOUR meds against Bilberry 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry 275

Individual Drug Interactions

The ingredients in Bilberry 100 mg interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bilberry 100 mg interact with drugs. Each result below shows which ingredient is responsible. Bilberry

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry 100 mg, from the product label.

Natures Plus Herbal Actives

See all Natures Plus Herbal Actives products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Bilberry 100 mg by Natures Plus Herbal Actives: Common Questions

Does Bilberry 100 mg by Natures Plus Herbal Actives interact with any medications?
Yes. Based on its ingredients, Bilberry 100 mg has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is bilberry safe if I'm pregnant or breastfeeding?
Yes, bilberry is rated likely safe in pregnancy and lactation. That said, long-term supplement safety data are limited, so talk with your doctor or pharmacist about whether it makes sense for you personally.
Will bilberry really improve my night vision?
No. Night vision is rated possibly ineffective, meaning the evidence doesn't support that claim. You'll want to look at other strategies or talk with your doctor if night vision is a concern.
What side effects should I expect?
Most common are dark stools, gas, and mild digestive discomfort. Your stools, tongue, or teeth may turn dark bluish or black—it's harmless but worth expecting. If you have ulcerative colitis or other GI conditions, flatulence and digestive upset may be more likely.
Does bilberry help with AMD (age-related macular degeneration) or memory problems?
We don't have enough reliable evidence to say whether it works for either. If you're dealing with those issues, your doctor can help you weigh whether bilberry is worth a try.
Can I take bilberry with my aspirin or other blood thinner?
Don't start it without checking first. Bilberry may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Talk with your doctor or pharmacist before adding it.
What's in this tablet besides bilberry?
The rest are inactive ingredients—binders and fillers like microcrystalline cellulose, calcium phosphate, magnesium stearate, and silica—to hold the tablet together. None are active.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry 100 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry 100 mg label
Go deeper

The Full Monographs Behind Bilberry 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Bilberry 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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