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Dietary supplement

Bilberry Extract Ingredients & Drug Interactions

by Wonder Laboratories

Bilberry Extract label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry Extract is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry 25:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry Extract by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry Extract by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bilberry Extract by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Wonder Laboratories Bilberry Extract contains one active ingredient: a concentrated bilberry fruit extract at 25:1 strength, meaning it's made by processing 25 pounds of bilberry down to 1 pound of extract. The softgel capsule also holds inactive ingredients — gelatin, soybean oil, vegetable glycerin, soy lecithin, beeswax, and caramel color — that help deliver the extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bilberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: nutritionally supports healthy eye function.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Glaucoma — and 4 related terms.
  • The closest evidence on file: Bilberry is rated "Possibly Ineffective" for Night vision (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Diabetic retinopathy, Dry eye, and more.

The evidence on bilberry for its common uses is mixed and limited. For night vision, the data suggests it's likely ineffective.

For age-related cognitive decline, age-related macular degeneration (AMD), hardening of the arteries (atherosclerosis), high cholesterol (hyperlipidemia), and chronic venous insufficiency (a blood flow problem in the legs), there simply isn't enough reliable evidence to know whether it works. If you're considering bilberry for any of these, talk with your doctor or pharmacist about whether the evidence supports trying it.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit as a food is generally well tolerated, but concentrated supplement safety and long-term effects haven't been well studied. The main side effects you might notice are dark-colored stools, flatulence, and stomach discomfort — some people also see temporary discoloration of their tongue, teeth, or stool.

One small trial reported mild-to-moderate bloating in about a third of participants, though those patients had ulcerative colitis, which limits what we can conclude. Bilberry is likely safe in pregnancy and breastfeeding, but because long-term safety data is sparse, it's best to check with your doctor or pharmacist before using a concentrated supplement during pregnancy or while nursing.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this bilberry supplement, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — bilberry may increase bleeding risk. Also confirm it's okay if you use diabetes medications, drugs metabolized by the liver enzyme CYP2E1, or erlotinib (Tarceva), since bilberry may affect how these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bilberry extract may appeal to you if you're interested in antioxidant support, but the evidence that it actually improves night vision or cognitive health is weak. Before taking it — especially if you use blood thinners, diabetes medications, or erlotinib — check your exact medications with your doctor or pharmacist, since bilberry may interfere with how they work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry Extract, straight from the product label.

Brand Wonder Laboratories
Barcode (UPC) 099528403103
Net contents 100 Softgel(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 215163
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry Extract by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
099528403103
IngredientAmount% DV
Bilberry 25:1 extract60 mg--

Other ingredients: Gelatin, Soybean Oil, Vegetable Glycerin, Soy Lecithin, yellow Beeswax, natural Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bilberry nutritionally supports healthy eye function. Bilberry also possesses antioxidant properties that help neutralize cell-damaging free radicals.

Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Contains soy ingredients.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Formulation

Manufactured in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Contains: No artificial flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no wheat, no yeast, no fish, Non-GMO.

Bilberry Extract equivalent to 1500 mg Bilberry

Nutritionally supports healthy eye function

Gluten free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Reorder #4031

Made in USA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 softgel daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry Extract by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry Extract by Wonder Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Bilberry 25:1 extract

Interacts with
275 drugs
60 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry 25:1 extract monograph & interactions

Other (inactive) ingredients: Gelatin, Soybean Oil, Vegetable Glycerin, Soy Lecithin, Yellow Beeswax, Natural Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry Extract by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Bilberry Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry 25:1 extract 275

Individual Drug Interactions

The ingredients in Bilberry Extract interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bilberry Extract interact with drugs. Each result below shows which ingredient is responsible. Bilberry 25:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry 25:1 extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry 25:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry Extract, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Bilberry Extract by Wonder Laboratories: Common Questions

Does Bilberry Extract by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Bilberry Extract has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is bilberry extract safe to take while I'm pregnant or breastfeeding?
Bilberry is rated likely safe in pregnancy and breastfeeding, but long-term safety data is limited. Talk with your doctor or pharmacist before using concentrated supplements while pregnant or nursing to make sure it's right for your situation.
What are the most common side effects?
Bilberry is generally well tolerated. The most common side effects are dark-colored stools, gas, and mild stomach discomfort. You might also notice temporary darkening of your tongue or teeth. These effects are usually mild.
Will bilberry really help my night vision?
The evidence suggests bilberry is likely ineffective for improving night vision. If you're hoping to support your eyesight, talk with your doctor or pharmacist about approaches with stronger research backing.
Does bilberry help with age-related cognitive decline or macular degeneration?
There isn't enough reliable evidence to know whether bilberry works for either of these. The research so far is too limited to say yes or no, so your doctor or pharmacist can help you weigh whether trying it makes sense.
Can I take bilberry with my blood pressure or blood thinner medications?
You'll want to check with your doctor or pharmacist before combining bilberry with blood thinners or antiplatelet drugs, since bilberry may increase your bleeding risk — that's a Moderate-severity interaction to confirm is safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry Extract label
Go deeper

The Full Monographs Behind Bilberry Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Bilberry Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Ln&ecaron;ni&ccaron;kov&aacute; K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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