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Dietary supplement

Bilberry Extract Powder 500 mg Ingredients & Drug Interactions

by BulkSupplements.com

Bilberry Extract Powder 500 mg label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry Extract Powder 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry Extract Powder 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry Extract Powder 500 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry Extract Powder 500 mg by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bilberry Extract Powder 500 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Bilberry Fruit Extract, 500 mg per serving. Bilberries are small dark berries rich in compounds called anthocyanidins, which give them their deep color and are thought to be their active component.

The powder also contains maltodextrin, an inactive ingredient used as a carrier.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Bilberry product and its label doesn't state a use — see Bilberry's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for bilberry extract is mixed and limited. For night vision, current data suggests it's probably not effective.

For age-related cognitive decline, macular degeneration (AMD), atherosclerosis, high cholesterol (hyperlipidemia), and chronic venous insufficiency (a vein circulation problem), we don't have enough reliable evidence to know whether it works or doesn't.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit as food is generally well tolerated. As a concentrated supplement, though, safety data are sparse and long-term effects aren't well studied — we'd advise caution.

The most common side effects are dark-colored stools (which can be quite dark, even bluish-black), gas, and stomach discomfort. In clinical trials, a small number of participants reported temporary gas or GI upset, and in one case a slight discoloration of the teeth was noted.

Pregnancy and lactation: Bilberry fruit is rated likely safe in pregnancy and breastfeeding, but that rating applies to food amounts — safety data for concentrated supplement doses in pregnant or nursing people are not established.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take blood thinners or antiplatelet drugs (such as warfarin or aspirin), diabetes medications, the cancer drug erlotinib (Tarceva), or any other drugs broken down by the liver enzyme CYP2E1. Altogether, these interactions span 274 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bilberry extract is generally well tolerated as a food, but supplement safety data are limited. If you take blood thinners, diabetes drugs, or certain cancer medications, you'll want to check with your pharmacist before starting.

Even if you don't take those, a quick medication review is worth your time.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry Extract Powder 500 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X0019RSDET
Net contents 250 Gram(s); 8.8 Ounce(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 330412
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry Extract Powder 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 Milligram(s)
Maximum serving Sizes:
500 Milligram(s)
Servings per container
500
UPC/BARCODE
X0019RSDET
IngredientAmount% DV
Bilberry Fruit Extract500 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bilberry Extract Powder 500 mg per serving

Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Formulation

Color may vary

Free of: Added sugar, soy, dairy, yeast, gluten

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 500 mg (about 1/5 tsp) once or twice daily, or as directed by a physician.

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place

General Statements

Use an accurate milligram scale. New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry Extract Powder 500 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry Extract Powder 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry Extract Powder 500 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 Milligram(s) Dosage formPowder Servings per container500 Amounts shown are per serving.

Bilberry Fruit Extract

Interacts with
275 drugs
500 mg per serving Form: Vaccinium myrtillus Fruit Extract

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry Fruit Extract monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry Extract Powder 500 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Bilberry Extract Powder 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry Fruit Extract 275

Individual Drug Interactions

The ingredients in Bilberry Extract Powder 500 mg interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bilberry Extract Powder 500 mg interact with drugs. Each result below shows which ingredient is responsible. Bilberry Fruit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry Extract Powder 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry Fruit Extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry Fruit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry Extract Powder 500 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Bilberry Extract Powder 500 mg by BulkSupplements.com: Common Questions

Does Bilberry Extract Powder 500 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Bilberry Extract Powder 500 mg has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry Extract Powder 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is bilberry extract supposed to do?
Bilberry is marketed for eye health and cognitive function. The evidence for night vision shows it's probably not effective. For age-related cognitive decline and macular degeneration, we don't have enough reliable data to say whether it works.
Will my stools really turn dark?
Yes — that's a common side effect, and the discoloration can be quite dark, even bluish-black. It's harmless and temporary, but worth knowing about so you don't worry if it happens.
Is it safe to take while pregnant or breastfeeding?
Bilberry fruit is rated likely safe during pregnancy and breastfeeding. However, that safety rating is based on food amounts, not concentrated supplement doses — safety data for supplements in pregnant or nursing people aren't well established. Talk with your doctor or pharmacist about whether this dose is right for you.
Why is the powder so dark?
Bilberries are naturally deep blue and dark purple because of anthocyanidins, the compounds responsible for their color and their supposed health benefits.
Can I take this long-term?
Long-term safety data for concentrated bilberry supplements are limited. Food amounts are considered safe, but we don't know as much about prolonged use of this powder, so caution is advised.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry Extract Powder 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry Extract Powder 500 mg label
Go deeper

The Full Monographs Behind Bilberry Extract Powder 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Bilberry Extract Powder 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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