Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Biocell Collagen Ingredients & Drug Interactions

by OL Olympian Labs, Inc. The Optimal Blend

Biocell Collagen label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biocell Collagen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Biocell Collagen is a dietary supplement by OL Olympian Labs, Inc. The Optimal Blend with 3 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, joint stiffness, cartilage support.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend

Ask about any prescription or over-the-counter medication and we check it for interactions with Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “BioCell Collagen” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Biocell Collagen contains three active ingredients: chondroitin sulfate, hyaluronic acid, and hydrolyzed chicken collagen type II. Chondroitin and collagen are building blocks that may support joint and skin health; hyaluronic acid is a substance your body naturally produces to keep skin and eyes moist.

The capsules also contain inactive ingredients — rice flour, gelatin, cellulose, ascorbyl palmitate, and silicon dioxide — that serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: skin hydration and joint comfort.
  • We looked for evidence on: Aging skin, Osteoarthritis, Wound healing, Fine lines and wrinkles, Joint mobility.
  • The strongest evidence on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Aging skin.
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Osteoarthritis, Wound healing.

The evidence for chondroitin sulfate is mixed. It's rated possibly effective for cataracts and osteoarthritis, but the data isn't strong enough to rate it for aging skin, osteoporosis, high cholesterol, or colorectal adenoma prevention.

Hyaluronic acid is rated possibly effective for dry eye and venous leg ulcers, though again the evidence for aging skin and allergies isn't established. We have no effectiveness data on file for hydrolyzed chicken collagen type II.

The evidence, ingredient by ingredient Chondroitin Sulfate Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chondroitin sulfate is generally well tolerated for short-term use, though quality and benefit vary. The most common side effects are gastrointestinal — abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea.

Rare reports exist of liver damage, and skin symptoms like swelling, rash, and hair loss have been reported, especially in combination products with glucosamine. A case of asthma worsening and sun sensitivity has also been reported.

Hyaluronic acid is generally well tolerated when taken by mouth, though long-term safety of oral supplements hasn't been fully studied. When applied topically, it may cause eczema, redness, itching, or rarely eye pain.

The safety data advises against chondroitin during pregnancy and breastfeeding — there isn't enough information to know it's safe. Hyaluronic acid safety data in pregnancy and lactation is limited, so talk with your doctor or pharmacist before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Chondroitin Sulfate Hyaluronic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Chondroitin Sulfate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, double-check before starting — chondroitin sulfate may increase its effect on your blood. No other medication interactions are documented for the ingredients we could check, but we hold no data on hydrolyzed chicken collagen type II.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people looking to support joint and skin health, though the evidence for aging skin is limited. If you take warfarin or any blood thinner, check with your pharmacist first — chondroitin can interfere with how these drugs work.

Pregnant or breastfeeding women should discuss it with their doctor. It's generally well tolerated, but digestive upset and rare skin reactions are possible.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biocell Collagen, straight from the product label.

Brand OL Olympian Labs, Inc. The Optimal Blend
Barcode (UPC) 710013000767
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2014
DSLD ID 39346
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
710013000767
IngredientAmount% DV
Chondroitin Sulfate200 mg--
Hyaluronic Acid100 mg--
BioCell Collagen1000 mg--
Hydrolyzed Chicken Collagen Type II600 mg--

Other ingredients: Rice Flour, Gelatin, Cellulose, Ascorbyl Palmitate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two (2) capsules daily or as directed by a healthcare professional.

Precautions

Caution: If you are pregnant, nursing or have a medical condition, or are taking medication, consult your healthcare professional before taking this or any other nutritional supplement.

Discontinue use if allergic reaction occurs.

KEEP OUT OF REACH OF CHILDREN.

Brand IP Statement(s)

BioCell Collagen(R) is a low molecular weight collagen that is easily absorbed as well as proven, effective and fast acting.

General Statements

Improves skin moisture by 72% and helps reduce fine lines and wrinkles. Also supports joint comfort and mobility.

THE OPTIMAL BLEND

~Clinically Proven to Reduce Fine Lines and Wrinkles ~Supports Skin Hydration

30 SERVINGS

Made in USA

Storage

STORE IN A COOL, DRY PLACE.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This products is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

OL OLYMPIAN LABS, INC.(TM)

Formula

FOR DYNAMIC WOMEN(TM)

FDA Statement of Identity

DIETARY SUPPLEMENT

General

PN 1008-00 REV 8/27/13

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biocell Collagen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

BioCell Collagen

1000 mg per serving

Other (inactive) ingredients: Rice Flour, Gelatin, Cellulose, Ascorbyl Palmitate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend Drug Interactions

Want to check YOUR meds against Biocell Collagen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Biocell Collagen interact with 2 drugs. Click any drug to see the details.

1 of the 3 ingredients in Biocell Collagen interact with drugs. Each result below shows which ingredient is responsible. Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Biocell Collagen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Biocell Collagen, from the product label.

OL Olympian Labs, Inc. The Optimal Blend

See all OL Olympian Labs, Inc. The Optimal Blend products
Name
Olympian Labs, Inc.
City
Phoenix
State
AZ
ZipCode
85027
Phone Number
1.800.473.5883
Web Address
www.olympianlabs.com
Pharmacist Counseling Corner

Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend: Common Questions

Does Biocell Collagen by OL Olympian Labs, Inc. The Optimal Blend interact with any medications?
Yes. Based on its ingredients, Biocell Collagen has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biocell Collagen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with wrinkles or aging skin?
The evidence isn't established for aging skin — the data we have is insufficient to say whether it works for that. It may help with dry eyes and leg ulcers, and chondroitin is possibly effective for osteoarthritis.
What are the most common side effects?
Chondroitin sulfate can cause digestive upset — bloating, constipation, diarrhea, heartburn, or nausea. Rashes and skin swelling have been reported rarely. Hyaluronic acid is well tolerated when taken by mouth.
Is it safe to take while pregnant?
The safety data for chondroitin advises against it during pregnancy — there isn't enough information to know it's safe. Hyaluronic acid also has limited pregnancy safety data. Talk with your doctor or pharmacist for personalized advice.
Can I take this while breastfeeding?
The safety data advises against chondroitin while breastfeeding due to lack of information. Hyaluronic acid also has limited breastfeeding data. Check with your doctor or pharmacist before using.
How long can I take this safely?
Chondroitin is generally well tolerated for short-term use, though the long-term safety of supplements hasn't been fully studied. It's best to talk with your pharmacist about how long to use it.
Does hyaluronic acid have any interactions with medications?
No interactions are documented in our data for hyaluronic acid, though that's not a guarantee none exist. Your pharmacist can check your specific medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biocell Collagen label
Go deeper

The Full Monographs Behind Biocell Collagen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph →
Sources

Sources & How We Checked

Biocell Collagen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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