Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Black Seed Oil Cardio-POWER Ingredients & Drug Interactions

by Physician's Strength

Black Seed Oil Cardio-POWER label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Seed Oil Cardio-POWER against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Black Seed Oil Cardio-POWER is a dietary supplement by Physician's Strength with 4 active ingredients. Its ingredients are commonly taken for respiratory support (asthma, allergies, cough), digestive upset, immune support.Based on those ingredients, 912 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Cumin (seed) oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Black Seed Oil Cardio-POWER by Physician's Strength

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Seed Oil Cardio-POWER by Physician's Strength — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Black Seed Oil Cardio-POWER by Physician's Strength

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Black Seed Oil Cardio-POWER contains 4 active ingredients. The main one is black cumin (seed) oil—a traditional extract rich in compounds like thymoquinone that give it its active properties.

The other three actives are thymoquinone (a key component of black seed), omega-6, and omega-9 fatty acids. The product also contains inactive ingredients: extra virgin black cumin seed oil (cold-pressed), pomegranate syrup, and muscadine skin extract, which serve as fillers and for flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: heart and artery natural support.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Endothelial function, Arterial compliance.
  • The strongest evidence on file: Black Seed is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Black Seed is rated "Possibly Effective" for Hypertension.
  • Also on file: Black Seed is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD).

Black seed shows possibly effective evidence for several conditions in our data: acne, hay fever (allergic rhinitis), asthma, helicobacter pylori infection (a stomach bacterium), and diabetes. This means some clinical research supports its use, but the evidence isn't conclusive yet.

If you're considering this product for one of those reasons, talk with your pharmacist about what the research actually shows and whether it's right for your situation.

The evidence, ingredient by ingredient Black Seed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, black seed is generally well tolerated. The most common side effects are gastrointestinal—constipation, nausea, vomiting, gastric burning, and discomfort—affecting roughly one in five people in one trial.

One patient was hospitalized for severe nausea and vomiting, and one trial reported unusually heavy menstrual bleeding. Small food amounts are considered likely safe, but higher supplement doses haven't been studied long-term.

Pregnancy is a concern: larger medicinal amounts are not considered safe in pregnancy, so you should avoid supplement doses if you're pregnant or trying to conceive. There isn't enough reliable safety information for breastfeeding, so talk with your doctor or pharmacist for personalized advice if you're nursing.

Side effects, ingredient by ingredient Black Seed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Black Seed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 912 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check your medications if you take blood thinners like warfarin or aspirin (Moderate), blood pressure lowering drugs (Moderate), diabetes medications (Moderate), antidepressants or migraine drugs that boost serotonin (Moderate), sedating medications (Moderate), water pills or diuretics (Moderate), immune-suppressing drugs like cyclosporine (Moderate), or other immunosuppressants (Moderate). No interactions are documented for thymoquinone, omega-6, or omega-9 since we could not check those ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with acne, asthma, hay fever, stomach infections, or blood sugar—though the evidence is still developing. It's not for you if you take blood thinners, blood pressure medications, diabetes drugs, or immune-suppressing medications without checking first.

Avoid it in pregnancy. Talk to your pharmacist about whether it fits your health picture and your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Seed Oil Cardio-POWER, straight from the product label.

Brand Physician's Strength
Barcode (UPC) 850032454230
Net contents 8 Fluid Ounce(s); 240 mL
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 268682
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Seed Oil Cardio-POWER by Physician's Strength, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
48
UPC/BARCODE
850032454230
IngredientAmount% DV
Trans Fat0 Gram(s)--
Total Fat5 Gram(s)7.5%
Saturated Fat1 Gram(s)5%
Calories50 Calorie(s)--
Calories from Fat45 Calorie(s)--
Thymoquinone38 mg--
Black Cumin (seed) oil4.9 Gram(s)--
Omega-62.6 Gram(s)50%
Omega-91.2 Gram(s)25%

Other ingredients: Extra Virgin Black Cumin Seed Oil, Cold-Pressed, Pomegranate Syrup, Muscadine Skin Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one or more teaspoonfuls daily. Makes a tasty addition to any food such as salad, soup, or vegetables. Also add to smoothies. Shake well.

Formula

Black seed oil Cardio-POWER is a pure complex of mediterranean heart and artery natural power sources: cold-pressed black seed oil, sour pomegranate, and muscadine grape skin concentrate. Pomegranate and muscadine, natural sources of ellagic acid, resveratrol, and punicalagins, support a healthy cardiac system and blood pressure. Black Seed Oil Cardio-POWER is the ideal heart health-supporting oil complex for prevention and better health. It's potent to the extreme.

Thymoquinone + nigellone Ellagic acid/Resveratrol-Plus

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

Doctor's formula

Guaranteed Non-GMO

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Seed Oil Cardio-POWER by Physician's Strength label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Seed Oil Cardio-POWER label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Seed Oil Cardio-POWER by Physician's Strength

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Gram(s) Dosage formLiquid Servings per container48 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thymoquinone

38 mg per serving

Black Cumin (seed) oil

Interacts with
912 drugs
4.9 Gram(s) per serving

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with ear...

Black Cumin (seed) oil monograph & interactions

Omega-6

2.6 Gram(s) per serving

Omega-9

1.2 Gram(s) per serving

Other (inactive) ingredients: Extra Virgin Black Cumin Seed Oil, Cold-Pressed, Pomegranate Syrup, Muscadine Skin Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Seed Oil Cardio-POWER by Physician's Strength Drug Interactions

Want to check YOUR meds against Black Seed Oil Cardio-POWER?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
912Drugs
912 Moderate

Ingredients driving the most interactions

Black Cumin (seed) oil 912

Individual Drug Interactions

The ingredients in Black Seed Oil Cardio-POWER interact with 912 drugs. Click any drug to see the details.

1 of the 4 ingredients in Black Seed Oil Cardio-POWER interact with drugs. Each result below shows which ingredient is responsible. Black Cumin (seed) oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Seed Oil Cardio-POWER with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Cumin (seed) oil14 drug types · 912 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D
Black Cumin (seed) oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Seed Oil Cardio-POWER, from the product label.

Physician's Strength

See all Physician's Strength products
Name
Physician's Strength
Street Address
13900 W. Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-800-243-5242
Pharmacist Counseling Corner

Black Seed Oil Cardio-POWER by Physician's Strength: Common Questions

Does Black Seed Oil Cardio-POWER by Physician's Strength interact with any medications?
Yes. Based on its ingredients, Black Seed Oil Cardio-POWER has a known interaction with 912 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Seed Oil Cardio-POWER contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No—larger medicinal amounts of black seed are not considered safe in pregnancy, so you should avoid supplement doses. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before using this product.
What side effects might I notice?
The most common are stomach-related: constipation, nausea, vomiting, burning sensation, or mild discomfort. A small number of trial participants reported more severe gastrointestinal problems, and one trial noted unusually heavy menstrual bleeding. Most people tolerate it well.
Does it actually work for blood sugar or heart health?
Black seed shows possibly effective evidence for diabetes in our data, meaning some clinical research supports it but the evidence isn't conclusive yet. We don't have an effectiveness rating specifically for heart health on file for this product, so ask your pharmacist what the research says for your particular reason.
Is it safe to use long-term?
Small food amounts of black seed are considered likely safe, but higher supplement doses haven't been studied long-term, so caution is warranted if you're thinking of using it regularly for months or years. Talk with your pharmacist about the right duration for your situation.
Can I breastfeed while taking this?
There isn't enough reliable safety information to say either way. Talk with your doctor or pharmacist for personalized advice if you're nursing, so you can make the best choice for you and your baby.
What's thymoquinone?
It's a key active compound found naturally in black seed and listed here as its own ingredient. Some of the blood sugar effects people associate with black seed come from thymoquinone. We couldn't check its interaction profile independently, but it's part of what makes black seed work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Seed Oil Cardio-POWER label
Go deeper

The Full Monographs Behind Black Seed Oil Cardio-POWER’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Seed

Interacts with 912 drugs

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...

Read the full Black Seed monograph →
Sources

Sources & How We Checked

Black Seed Oil Cardio-POWER's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 60 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Seed 60 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
  3. Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
  4. Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9. PubMed
  5. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008;22:447-52.
  6. Zaoui, A., Cherrah, Y., Lacaille-Dubois, M. A., Settaf, A., Amarouch, H., and Hassar, M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000;55(3):379-382.
  7. Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. PubMed
  8. Meral, I., Yener, Z., Kahraman, T., and Mert, N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet.Med A Physiol Pathol.Clin Med 2001;48(1
  9. Al Jishi, S. A. and Abuo, Hozaifa B. Effect of Nigella sativa on blood hemostatic function in rats. J Ethnopharmacol. 2003;85(1):7-14. PubMed
  10. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
  11. Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88(1):63-68. PubMed
  12. Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
  13. Islam, S. N., Begum, P., Ahsan, T., Huque, S., and Ahsan, M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother.Res. 2004;18(5):395-398.
  14. Fararh, K. M., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., and Takewaki, T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet.Sci 2004;77(2):123-129. PubMed
  15. Awad, E. M. and Binder, B. R. In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa. Phytomedicine 2005;12(3):194-202. PubMed
  16. El Obeid, A., Al Harbi, S., Al Jomah, N., and Hassib, A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine. 2006;13(5):324-333.
  17. Abbas, A. T., Abdel-Aziz, M. M., Zalata, K. R., and Tel, Abd Al-Galel. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Im
  18. Kaleem, M., Kirmani, D., Asif, M., Ahmed, Q., and Bano, B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp.Biol. 2006;44(9):745-748.
  19. Hawsawi, Z. A., Ali, B. A., and Bamosa, A. O. Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann.Saudi Med 2001;21(3-4):242-244.
  20. Massadeh, A. M., Al Safi, S. A., Momani, I. F., Al Mahmoud, M., and Alkofahi, A. S. Analysis of cadmium and lead in mice organs: effect of Nigella sativa L. (Black Cumin) on the distribution and immunosuppressive effect of cadmium-lead mixture in mice. B PubMed
  21. Akhondian, J., Parsa, A., and Rakhshande, H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13(12):CR555-CR559.
  22. Meddah, B., Ducroc, R., El Abbes, Faouzi M., Eto, B., Mahraoui, L., Benhaddou-Andaloussi, A., Martineau, L. C., Cherrah, Y., and Haddad, P. S. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol. PubMed
  23. Najmi, A., Nasiruddin, M., Khan, R. A., and Haque, S. F. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev.Ctries. 2008;28(1):11-14.
  24. al Sheikh, O. A. and Gad el-Rab, M. O. Allergic contact dermatitis: clinical features and profile of sensitizing allergens in Riyadh, Saudi Arabia. Int J Dermatol. 1996;35(7):493-497.
  25. Steinmann, A., Schatzle, M., Agathos, M., and Breit, R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis 1997;36(5):268-269.
  26. Al-Jenoobi FI, Al-Suwayeh SA, Muzaffar I, et al. Effects of Nigella sativa and Lepidium sativum on cyclosporine pharmacokinetics. Biomed Res Int 2013;2013:953520.
  27. Arslan E, Sayin S, Demirbas S, et al. A case study report of acute renal failure associated with Nigella sativa in a diabetic patient. J Integr Med 2013;11:64-6. PubMed
  28. Bamosa AO, Kaatabi H, Lebdaa FM, et al. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010;54:344-54.
  29. Bonhomme A, Poreaux C, Jouen F, et al. Bullous drug eruption to Nigella sativa oil: Consideration of the use of a herbal medicine - clinical report and review of the literature. J Eur Acad Dermatol Venereol 2017;31:e217-e219.
  30. Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled
  31. Kaatabi H, Bamosa AO, Badar A, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial. PLoS One 2015;10:e0113486. PubMed
  32. Mohtashami R, Huseini HF, Heydari M, et al. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol 2015;175:147-52. PubMed
  33. Perveen T, Haider S, Zuberi NA, et al. Increased 5-HT levels following repeated administration of Nigella sativa L. (Black Seed) oil produce antidepressant effects in rats. Sci Pharm 2013;82:161-70. PubMed
  34. Sahebkar A, Soranna D, Liu X, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens 2016;34:2127-35. PubMed
  35. Shawki M, El Wakeel L, Shatla R, et al. The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study. Epileptic Disord 2013;15:295-301. PubMed
  36. Muneera KE, Majeed A, Naveed AK. Comparative evaluation of nigella sativa (Kalonji) and simvastatin for the treatment of hyperlipidemia and in the induction of hepatotoxicity. Pak J Pharm Sci. 2015 Mar;28(2):493-8.
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See these in context on the Black Seed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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