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Dietary supplement

Boldo and Fringe Ingredients & Drug Interactions

by Hawaii Pharm

Boldo and Fringe label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boldo and Fringe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boldo and Fringe is a dietary supplement by Hawaii Pharm with 2 active ingredients. Its ingredients are commonly taken for indigestion and bloating, mild constipation, liver and gallbladder support.Based on those ingredients, 482 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Boldo extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Boldo and Fringe by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Boldo and Fringe by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Boldo and Fringe by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 2 active ingredients: wildcrafted boldo extract and Fringe Tree extract. Boldo has a long history in herbal medicine and is thought to support liver and gallbladder function, though the evidence for those uses is limited.

Fringe Tree is included for similar traditional purposes, but safety and effectiveness data are very sparse. The product also contains vegetable palm glycerin and pharmaceutical-grade alcohol as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for boldo isn't well established. The data we hold rates its use for benign prostatic hyperplasia, gallbladder disease, kidney stones, and joint pain all as having insufficient reliable evidence to rate.

Fringe Tree effectiveness hasn't been rated in our data — the evidence isn't established for any use we hold on file.

The evidence, ingredient by ingredient Boldo Fringetree

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boldo is generally well tolerated in small food-like amounts, but at medicinal doses it can cause real problems. The most common side effects are abdominal pain, nausea, and vomiting.

The bigger concern is liver damage — boldo contains ascaridole, a liver toxin, and hepatotoxicity (harm to liver cells) has been reported in people taking it medicinally, sometimes with elevated liver enzymes and jaundice. Boldo is considered unsafe in pregnancy because it may stimulate the uterus, and it should be avoided while breastfeeding due to insufficient safety data.

Fringe Tree has very limited human safety information and should be avoided during pregnancy and breastfeeding as well. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Boldo Fringetree

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Boldo.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; lithium.
  • For scale: 483 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood thinners or antiplatelet drugs like warfarin, any medications that can harm the liver, lithium, or tacrolimus. These interactions are moderate-severity and may affect how your medications work or increase your risk of side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Boldo and Fringe is not a good choice if you take blood thinners, have liver disease, take lithium, or have had a transplant — the interactions are significant. Even if you don't take those medications, boldo's liver toxicity is a real concern with regular or long-term use.

Talk with your doctor or pharmacist before starting this product, especially if you take any prescription medications or have any liver concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boldo and Fringe, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 650905482595
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 237351
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boldo and Fringe by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
650905482595
IngredientAmount% DV
Blend0 NP--
wildcrafted Boldo extract250 mcL--
Fringe Tree extract250 mcL--

Other ingredients: Vegetable Palm Glycerin, pharmaceutical grade Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Herbal Extract Highest quality since 2008

Made with Aloha!

Formulation

Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.

Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.

Manufactured in an FDA registered facility.

Non GMO Gluten free

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.

Precautions

Warning: Keep out of the reach of children.

May have contraindications. We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing or taking any medications.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boldo and Fringe by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boldo and Fringe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boldo and Fringe by Hawaii Pharm

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Blend

0 NP per serving

Other (inactive) ingredients: Vegetable Palm Glycerin, Pharmaceutical grade Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boldo and Fringe by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Boldo and Fringe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
482Drugs
482 Moderate

Ingredients driving the most interactions

wildcrafted Boldo extract 482

Individual Drug Interactions

The ingredients in Boldo and Fringe interact with 482 drugs. Click any drug to see the details.

1 of the 2 ingredients in Boldo and Fringe interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Boldo extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Boldo and Fringe with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Boldo extract5 drug types · 482 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Animal and in vitro research shows that boldine, a constituent of boldo, has antiplatelet activity. In one case report, an adult taking a combination of boldo and fenugreek with warfarin experienced an increase in international normalized ratio (INR); however, it is unclear if this effect was due to boldo, fenugreek, the combination, or another factor.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Boldo leaf contains ascaridole, a known liver toxin. Many cases of hepatotoxicity, including elevated liver transaminase levels and jaundice, have been reported in patients taking boldo.

Likelihood Possible Evidence D
Lithium

Theoretically, taking boldo with lithium might increase the levels and clinical effects of lithium.
Boldo is believed to have diuretic effects. Theoretically, these diuretic effects might reduce the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tacrolimus (Prograf)

Taking boldo with tacrolimus may decrease the levels and clinical effects of tacrolimus, potentially increasing the risk of transplant rejection.
In one case report, a patient with a long-term history of stable tacrolimus levels developed subtherapeutic levels after taking boldo 300 mg twice daily orally for several weeks. Tacrolimus levels returned to normal after discontinuing boldo. However, the mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Warfarin (Coumadin)

A combination of boldo and fenugreek was thought to be associated with an increased international normalized ratio (INR) in a female on warfarin. It is not clear if boldo, fenugreek, or the combination played a role in this interaction. Therefore, boldo may have additive effects with warfarin.

Likelihood Possible Evidence D
wildcrafted Boldo extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boldo and Fringe, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Boldo and Fringe by Hawaii Pharm: Common Questions

Does Boldo and Fringe by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Boldo and Fringe has a known interaction with 482 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boldo and Fringe contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
No — boldo in this product has a documented moderate interaction with blood thinners like warfarin and may increase your bleeding risk. Talk with your doctor or pharmacist before adding this product if you take any blood thinner or antiplatelet drug.
Is boldo safe for the liver?
Boldo contains ascaridole, a known liver toxin, and cases of liver injury including elevated liver enzymes and jaundice have been reported in people taking boldo medicinally. At food-level amounts it's generally well tolerated, but this product is a concentrated extract — hepatotoxicity is a real concern, especially with regular use.
Can I take this while pregnant or breastfeeding?
No — boldo is considered unsafe in pregnancy because it may stimulate the uterus and should be avoided while breastfeeding. Fringe Tree also lacks reliable safety data in pregnancy and breastfeeding. Talk with your doctor before using this product if you're pregnant, planning to become pregnant, or breastfeeding.
What are the common side effects?
At medicinal doses, boldo can cause abdominal pain, nausea, and vomiting. The more serious concern is liver damage, which has been documented in case reports of people taking boldo. We don't have adverse-effect data for Fringe Tree on file.
Does this product actually work for what it's marketed to do?
The evidence isn't established for boldo's traditional uses — gallbladder support, kidney stones, and joint pain are all rated as having insufficient reliable evidence. Fringe Tree effectiveness also hasn't been rated in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Boldo and Fringe is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boldo and Fringe label
Go deeper

The Full Monographs Behind Boldo and Fringe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boldo

Interacts with 482 drugs

Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole,...

Read the full Boldo monograph → Herb & supplement monograph

Fringetree

Fringetree is a North American shrub whose root and stem bark have long been used in traditional herbal medicine, mainly for liver, gallbladder, and digestive complaints. There is very littl...

Read the full Fringetree monograph →
Sources

Sources & How We Checked

Boldo and Fringe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boldo 10 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
  3. Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
  4. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  5. Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
  6. Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
  7. Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
  8. Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
  9. Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
  10. Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed

See these in context on the Boldo monograph →

Fringetree 2 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

See these in context on the Fringetree monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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