Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Boldo Leaf Vanilla Flavor Ingredients & Drug Interactions

by TerraVita

Boldo Leaf Vanilla Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boldo Leaf Vanilla Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boldo Leaf Vanilla Flavor is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for indigestion and bloating, mild constipation, liver and gallbladder support.Based on those ingredients, 482 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boldo Leaf Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Boldo Leaf Vanilla Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Boldo Leaf Vanilla Flavor by TerraVita — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Boldo Leaf Vanilla Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: boldo leaf glycerite liquid extract. Boldo is a plant extract traditionally used for gallbladder and digestive concerns, though the evidence supporting these uses isn't well established.

The other ingredients — glycerin and vanilla flavor — are inactive excipients that sweeten and preserve the liquid.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Boldo product and its label doesn't state a use — see Boldo's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for boldo leaf isn't solid in our data. Uses studied include benign prostate enlargement (BPH), gallbladder disease, kidney stones, and joint pain — but for all of them, the data we hold rates the evidence as insufficient to say whether it actually works.

The evidence, ingredient by ingredient Boldo

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boldo is generally well tolerated when used in small amounts found in food. At medicinal doses, though, it carries real risks.

The most serious is hepatotoxicity (liver injury) from ascaridole, the toxic compound in boldo leaf. Common side effects at higher doses include abdominal pain, nausea, and vomiting.

If you use it topically, dermatitis (skin irritation) can occur. Boldo is considered unsafe during pregnancy because it may stimulate the uterus.

There isn't enough safety data to recommend it while breastfeeding either. The safety notes advise using it only short-term at low doses if at all, given the liver toxin risk.

Side effects, ingredient by ingredient Boldo

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boldo.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; lithium.
  • For scale: 483 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any hepatotoxic drugs (drugs known to stress the liver), blood thinners like warfarin, lithium, or tacrolimus. These interactions are documented as Moderate severity and may require dose adjustments or monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Boldo Leaf Vanilla Flavor is a single-ingredient liquid extract with a checkered safety profile — it carries a real risk of liver injury and interacts with blood thinners, lithium, transplant medications, and other drugs that stress the liver. If you're on any prescription medication, especially a blood thinner or immunosuppressant, talk with your doctor or pharmacist before taking this product.

It's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boldo Leaf Vanilla Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435131821
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 281700
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boldo Leaf Vanilla Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435131821
IngredientAmount% DV
Boldo Leaf Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin, Vanilla flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5) Vanilla flavored

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boldo Leaf Vanilla Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boldo Leaf Vanilla Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boldo Leaf Vanilla Flavor by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Boldo Leaf Glycerite Liquid Extract

Interacts with
482 drugs
0.13 mL per serving

Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited....

Boldo Leaf Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Vanilla flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boldo Leaf Vanilla Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Boldo Leaf Vanilla Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
482Drugs
482 Moderate

Ingredients driving the most interactions

Boldo Leaf Glycerite Liquid Extract 482

Individual Drug Interactions

The ingredients in Boldo Leaf Vanilla Flavor interact with 482 drugs. Click any drug to see the details.

1 of the 1 ingredient in Boldo Leaf Vanilla Flavor interact with drugs. Each result below shows which ingredient is responsible. Boldo Leaf Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Boldo Leaf Vanilla Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Boldo Leaf Glycerite Liquid Extract5 drug types · 482 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Animal and in vitro research shows that boldine, a constituent of boldo, has antiplatelet activity. In one case report, an adult taking a combination of boldo and fenugreek with warfarin experienced an increase in international normalized ratio (INR); however, it is unclear if this effect was due to boldo, fenugreek, the combination, or another factor.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Boldo leaf contains ascaridole, a known liver toxin. Many cases of hepatotoxicity, including elevated liver transaminase levels and jaundice, have been reported in patients taking boldo.

Likelihood Possible Evidence D
Lithium

Theoretically, taking boldo with lithium might increase the levels and clinical effects of lithium.
Boldo is believed to have diuretic effects. Theoretically, these diuretic effects might reduce the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tacrolimus (Prograf)

Taking boldo with tacrolimus may decrease the levels and clinical effects of tacrolimus, potentially increasing the risk of transplant rejection.
In one case report, a patient with a long-term history of stable tacrolimus levels developed subtherapeutic levels after taking boldo 300 mg twice daily orally for several weeks. Tacrolimus levels returned to normal after discontinuing boldo. However, the mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Warfarin (Coumadin)

A combination of boldo and fenugreek was thought to be associated with an increased international normalized ratio (INR) in a female on warfarin. It is not clear if boldo, fenugreek, or the combination played a role in this interaction. Therefore, boldo may have additive effects with warfarin.

Likelihood Possible Evidence D
Boldo Leaf Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boldo Leaf Vanilla Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Boldo Leaf Vanilla Flavor by TerraVita: Common Questions

Does Boldo Leaf Vanilla Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Boldo Leaf Vanilla Flavor has a known interaction with 482 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boldo Leaf Vanilla Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is boldo safe to take long-term?
No. The safety data advises using boldo only short-term at low doses because of the liver toxin ascaridole in the leaf. Medicinal amounts can cause significant harm, especially to your liver, so this isn't a product for ongoing use.
What are the most common side effects?
At medicinal doses, the most common side effects are abdominal pain, nausea, and vomiting. Liver injury (hepatotoxicity) is a rare but serious risk, with cases of elevated liver enzymes and jaundice reported in people taking boldo.
Can I take boldo if I'm pregnant or breastfeeding?
No. Boldo is considered unsafe during pregnancy because it may stimulate the uterus. There isn't enough safety information to recommend it while breastfeeding either. Talk with your doctor about alternatives if you're in either situation.
Does boldo actually work for gallbladder problems?
The evidence isn't established in our data. Boldo is traditionally used for gallbladder disease, but the studies we hold rate the evidence as insufficient to say whether it actually works for this or other claimed uses.
Why does this interact with so many medications?
Boldo's interactions span hundreds of individual medications because many of them fall into the drug categories it affects — hepatotoxic drugs (drugs that can stress the liver), blood thinners, lithium, and others. If you're on any prescription medication, check it against the tool on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Boldo Leaf Vanilla Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boldo Leaf Vanilla Flavor label
Go deeper

The Full Monographs Behind Boldo Leaf Vanilla Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boldo

Interacts with 482 drugs

Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole,...

Read the full Boldo monograph →
Sources

Sources & How We Checked

Boldo Leaf Vanilla Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boldo 10 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
  3. Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
  4. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  5. Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
  6. Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
  7. Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
  8. Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
  9. Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
  10. Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed

See these in context on the Boldo monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team