CalPlex By Karuna Overview & Drug Interactions

Vitamin D is a fat-soluble vitamin that plays a crucial role in several bodily processes. It helps the body absorb calcium and phosphorus, which are necessary for healthy bones and teeth. It is also important for immune system function and may help to protect against certain diseases. Vitamin D is found in a variety of foods, including fatty fish, egg yolks, and fortified foods such as milk and cereal. It is also produced by the body when the skin is exposed to sunlight. Vitamin D supplements are available in a variety of forms, including tablets, capsules, and liquids. The recommended daily intake of vitamin D varies depending on age, sex, and other factors, and it is important to follow the dosage recommendations provided by a healthcare professional. There are several different forms of vitamin D available, with the two most popular being ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3).

Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Magnesium is a mineral that is essential for the proper functioning of the body. It plays a role in many important physiological processes, including the contraction and relaxation of muscles, the transmission of nerve impulses, and the regulation of blood pressure. Magnesium is found in a variety of foods, including leafy green vegetables, nuts, and grains, and it is also available as a dietary supplement. There are several different forms of magnesium that are available as supplements, all of which can be used to prevent deficiency. Additionally, magnesium is purported to have several different health benefits, such as improving sleep, reducing muscle cramps, reducing anxiety, and preventing or treating migraines. Although magnesium is essential for health, magnesium-containing foods and supplements can interact with some prescription medications if used at the same time.

Manganese is an essential trace mineral that plays a vital role in various physiological processes within the human body. It is required for proper brain function, bone formation, enzyme activation, and wound healing. Manganese also contributes to metabolism, antioxidant defense, and the formation of connective tissues.

Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Silicon, atomic number 14, is the second most abundant element on Earth, after oxygen. It is present in the human body in small amounts (such as in the skin, hair, and nails) and is considered a trace mineral in that regard. Dietary sources of silicon include oats, barley, rice, and some fruits/vegetables. Silicon is a popular dietary supplement, often consumed in the form of silica, which is a chemical compound made up of silicon and oxygen, or as silicic acid (also known as orthosilicic acid). Another common form of silicon utilized is Choline-stabilized orthosilicic acid (ch-OSA), which is the active ingredient in the popular product Biosil. Silicon is used for its purported effects to improve the health and appearance of the skin, hair, and nails. It has also historically been used for other health conditions, such as osteoporosis, cardiovascular disease, and cognitive decline.

Boron is a trace mineral that is found in a variety of foods, including fruits, vegetables, nuts, and legumes. It is also available as a dietary supplement. Boron is thought to play a role in bone health, as it may help the body metabolize calcium, magnesium, and phosphorus. Some preliminary research also suggests that boron may have anti-inflammatory effects and may help to improve cognitive function. However, more research is needed to confirm these potential benefits. It is important to note that boron is not an essential nutrient and deficiency is rare. The recommended dietary allowance (RDA) for boron is not established, however, the safe upper limit is 20mg/day. Taking high doses of boron can cause skin irritation, nausea, vomiting, and diarrhea. There are several patented forms of boron available in dietary supplements, such as Albion Bororganic Glycine.