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Dietary supplement

Certified European Bilberry Extract Ingredients & Drug Interactions

by Life Extension

Certified European Bilberry Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Certified European Bilberry Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Certified European Bilberry Extract is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are MirtoSelect European Bilberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Certified European Bilberry Extract by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Certified European Bilberry Extract by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Certified European Bilberry Extract by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: MirtoSelect European Bilberry extract, a concentrated form of bilberry fruit. The inactive ingredients are rice flour, vegetable cellulose, and L-leucine—these are fillers and binders that make up the capsule.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: eye and vision health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Glaucoma — and 4 related terms.
  • The closest evidence on file: Bilberry is rated "Possibly Ineffective" for Night vision (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Diabetic retinopathy, Dry eye, and more.

The evidence for bilberry's effectiveness is mixed and limited. Night vision shows possibly ineffective evidence.

For age-related cognitive decline, age-related macular degeneration, atherosclerosis, high cholesterol, and chronic venous insufficiency, the data we hold shows insufficient reliable evidence to rate whether it works. If you're considering this product for one of these uses, talk with your doctor about whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit itself is generally well tolerated when consumed as food, but long-term safety data for concentrated supplements is limited—the available evidence comes mainly from short-term studies. The most common side effects are dark-colored or dark-green stools (which is harmless but can be startling), flatulence, and mild gastrointestinal discomfort; a small number of trial participants reported these.

Your tongue and teeth may also temporarily darken. The safety data advises caution with concentrated bilberry supplements due to a lack of long-term safety information.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this bilberry extract, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—bilberry may increase bleeding risk. Also confirm it's okay if you take diabetes medications (it may lower blood sugar further), erlotinib (Tarceva) for cancer, or any drug metabolized by the CYP2E1 enzyme pathway, as the extract may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Life Extension's bilberry extract may appeal to you if you're interested in traditional eye or circulation support, but the evidence for most of those uses isn't well established in our data. If you take blood thinners, diabetes medications, or certain cancer drugs, you'll want to check with your own doctor or pharmacist before adding this—the interactions are real.

Even if you're not on those medications, discuss this supplement with your healthcare provider to confirm it fits your health needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Certified European Bilberry Extract, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870107316
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 59063
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Certified European Bilberry Extract by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870107316
IngredientAmount% DV
MirtoSelect European Bilberry extract100 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNINGS: ~ KEEP OUT OF REACH OF CHILDREN.

~ DO NOT EXCEED RECOMMENDED DOSE. ~ Do not purchase if outer seal is broken or damaged.

~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

General Statements

Scan for product info

Promotes Visual Acuity*

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) capsule daily with or without food, or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

36% Anthocyanins ~ 100 mg

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

MirtoSelect is a registered trademark of Indena, S.p.A., Milan, Italy.

MirtoSelect is a registered trademark of Indena, S.p.A., Milan, Italy.

General

Q01073C

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Certified European Bilberry Extract by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Certified European Bilberry Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Certified European Bilberry Extract by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

MirtoSelect European Bilberry extract

Interacts with
275 drugs
100 mg per serving Form: total Anthocyanidins

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

MirtoSelect European Bilberry extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Certified European Bilberry Extract by Life Extension Drug Interactions

Want to check YOUR meds against Certified European Bilberry Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

MirtoSelect European Bilberry extract 275

Individual Drug Interactions

The ingredients in Certified European Bilberry Extract interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Certified European Bilberry Extract interact with drugs. Each result below shows which ingredient is responsible. MirtoSelect European Bilberry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Certified European Bilberry Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

MirtoSelect European Bilberry extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
MirtoSelect European Bilberry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Certified European Bilberry Extract, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
Florida
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
www.lef.org
Pharmacist Counseling Corner

Certified European Bilberry Extract by Life Extension: Common Questions

Does Certified European Bilberry Extract by Life Extension interact with any medications?
Yes. Based on its ingredients, Certified European Bilberry Extract has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Certified European Bilberry Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is bilberry safe to take while pregnant or breastfeeding?
According to the safety data we hold, bilberry is rated likely safe during pregnancy and lactation. That said, every pregnancy is individual—talk with your doctor or pharmacist before starting any supplement, including this one.
What are the side effects?
Most people tolerate bilberry well. The most common side effects are dark-colored stools (harmless discoloration from the fruit's pigments), gas, and mild stomach discomfort. Your tongue and teeth may also darken temporarily. These effects are usually temporary.
Does bilberry actually improve night vision?
The data we hold rates night vision as possibly ineffective—meaning current evidence does not support that bilberry helps. If night vision is your main reason for trying this, you may want to discuss other approaches with your eye doctor.
Can I take bilberry if I have diabetes?
Bilberry may lower your blood sugar further when combined with diabetes medications, raising the risk of low blood sugar. Check with your doctor before starting—do not add this on your own if you're already managing diabetes with medication.
How much of this product is actually bilberry, versus filler?
This capsule contains MirtoSelect European Bilberry extract as the active ingredient, plus rice flour, vegetable cellulose, and L-leucine as inactive binders and fillers that hold the capsule together. The label or product description should specify the extract dose per capsule.
Is this product safe long-term?
While bilberry fruit eaten as food is considered safe, long-term safety data for concentrated bilberry supplements is limited. The safety data advises caution with concentrated doses due to lack of long-term research. Talk with your doctor about how long it's appropriate for you to take this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Certified European Bilberry Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Certified European Bilberry Extract label
Go deeper

The Full Monographs Behind Certified European Bilberry Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Certified European Bilberry Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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