Chewable Papaya Enzyme Ingredients & Drug Interactions
by NaturesPlus
What is this page for?
First and foremost: checking Chewable Papaya Enzyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chewable Papaya Enzyme is a dietary supplement by NaturesPlus with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chewable Papaya Enzyme by NaturesPlus
Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable Papaya Enzyme by NaturesPlus — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chewable Papaya Enzyme by NaturesPlus
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 3 active ingredients: protease, amylase, and papain — all digestive enzymes. Protease and papain break down proteins; amylase breaks down starches.
They're combined here to support digestion, though the evidence for how well they work isn't well established in our data. The tablet also contains several inactive ingredients — xylitol, fructose, microcrystalline cellulose, stearic acid, magnesium stearate, watermelon flavor, and natural color — which serve as sweeteners, binders, and flow agents.
Does it work?
No specific claim
The evidence for papain's effectiveness against cancer, dental cavities, radiation skin damage, exercise soreness, shingles, and intestinal parasites is insufficient — the data we hold doesn't support claims in any of these areas. We have no effectiveness ratings on file for protease or amylase in this product.
How safe is it?
Well-documented data
Protease and papain are generally well tolerated when taken by mouth at typical doses, though both can cause digestive upset or allergic reactions in sensitive people. Papain at high doses may be unsafe and could cause severe stomach inflammation or even esophageal perforation — rare but serious.
Occupational exposure to papain dust can trigger respiratory allergies like asthma; if you have known sensitivities to papain or papaya, be cautious. During pregnancy, concentrated papain and unripe papaya products should be avoided due to safety concerns.
Breastfeeding data is limited for papain, and there's little safety information for protease during breastfeeding — medical advice is recommended before use if you're nursing. No safety data is on file for amylase.
Meds to double-check
Moderate interaction found
If you take warfarin (Coumadin) or another blood thinner, check with your pharmacist before taking this product — papain may increase the medication's effects. For the other medications you're on, we have no documented interactions for the ingredients we could check, but that doesn't rule out interactions we haven't identified yet.
The bottom line
Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with digestion if you tolerate enzymes well, but the evidence for specific health claims is limited. If you're on warfarin or any blood thinner, talk to your pharmacist before starting it — that's the main concern.
Pregnant people and those breastfeeding should also check with their pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chewable Papaya Enzyme, straight from the product label.
| Brand | NaturesPlus |
|---|---|
| Barcode (UPC) | 097467044609 |
| Net contents | 180 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Dec 21, 2024 |
| DSLD ID | 319152 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chewable Papaya Enzyme by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Protease | 100 mcg | -- |
| Amylase | 1 mg | -- |
| Papain | 6 mg | -- |
Other ingredients: Xylitol, Fructose, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Watermelon Flavor, Natural, Natural Color
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Nutritional support for healthy digestion and overall well-being.
Free from synthetic: colors, preservatives. Free from milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy and sesame.
Vegetarian
Digestive Aid
Gluten free
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, chew one tablet with a meal.
Storage
Keep tightly closed in a cool, dry place.
Precautions
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Papaya Enzyme Supplement
Seals/Symbols
Quality Natural Supplements
Brand IP Statement(s)
Copyright Natural Organics
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chewable Papaya Enzyme by NaturesPlus label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chewable Papaya Enzyme by NaturesPlus
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsAmylase
Papain
Interacts with2 drugs
Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...
Papain monograph & interactionsOther (inactive) ingredients: Xylitol, Fructose, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Watermelon Flavor, Natural, Natural Color. These complete the product’s ingredient list but are not active constituents.
Chewable Papaya Enzyme by NaturesPlus Drug Interactions
HelloPharmacist Interaction Report
NaturesPlus Chewable Papaya Enzyme contains papain, which has a documented interaction with blood thinners (anticoagulants).
Papain may increase the effects and side effects of warfarin (Coumadin) — in one case report, a patient stable on warfarin developed an elevated blood-clotting measurement (INR) after taking a papaya supplement. The protease ingredient in this product was checked and shows no known interactions.
We could not check amylase for interactions, as we hold no data for it.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 2 individual medications.
If you take warfarin or any other blood thinner, check your exact medication with the search tool on this page before you start this product. Even if you're not on one of the drugs we've flagged, it's worth running through your full list — your pharmacist can help.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chewable Papaya Enzyme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chewable Papaya Enzyme interact with 2 drugs. Click any drug to see the details.
1 of the 3 ingredients in Chewable Papaya Enzyme interact with drugs. Each result below shows which ingredient is responsible. Papain
WarfarinWarfarin
How Warfarin interacts with Chewable Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Chewable Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chewable Papaya Enzyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Chewable Papaya Enzyme, from the product label.
NaturesPlus
See all NaturesPlus products- Name
- Natural Organics, Inc. makers of NaturesPlus
- Street Address
- 9500 New Horizons Blvd.
- City
- Amityville
- State
- New York
- ZipCode
- 11701
- Web Address
- naturesplus.com
Chewable Papaya Enzyme by NaturesPlus: Common Questions
Does Chewable Papaya Enzyme by NaturesPlus interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is this safe to take while breastfeeding?
What are the side effects?
Does this product actually work for digestion?
What's in the tablet besides the enzymes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chewable Papaya Enzyme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chewable Papaya Enzyme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographPapain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph →Sources & How We Checked
Chewable Papaya Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC