Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate Ingredients & Drug Interactions

by ProCaps Laboratories

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate is a dietary supplement by ProCaps Laboratories with 3 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,086 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Cocoa Flavanols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: cocoa flavanols (from the 66% cacao dark chocolate base) and natural plant sterol esters. Cocoa flavanols are compounds in cacao that give chocolate its antioxidant and heart-health properties.

The product also contains organic cacao dark chocolate and organic coffee as inactive ingredients — they're part of the food base itself, not added fillers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cholesterol reduction and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Hypertension, Atrial fibrillation, Heart failure, Peripheral arterial disease (PAD) — and 4 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Likely Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Cocoa is rated "Possibly Effective" for Cardiovascular disease (CVD).
  • Also on file: Black Psyllium is rated "Insufficient Reliable Evidence To Rate" for Hypertension.

The evidence strongest for cocoa flavanols is cardiovascular disease — the data rates it possibly effective for heart and blood vessel health. For stretch marks, the evidence suggests it's probably not effective.

For HIV/AIDS-related cholesterol problems, aging skin, and asthma, we don't have enough reliable evidence yet to say whether it works or doesn't.

The evidence, ingredient by ingredient Black Psyllium Cocoa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cocoa in food amounts is generally well tolerated, but here's what matters: it contains caffeine and related stimulants, and chocolate is often high in sugar and calories. Most people who eat chocolate get minor digestive effects — bloating, gas, nausea, constipation, or heartburn — but these are common and usually mild.

Rarely, cocoa can cause a faster heartbeat. Allergic skin reactions happen occasionally.

The takeaway is to keep your overall caffeine intake moderate and watch your sugar consumption, especially if you snack on chocolate regularly.

Side effects, ingredient by ingredient Black Psyllium Cocoa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Black Psyllium, Cocoa.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 2,087 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you use this product, double-check if you take ephedrine (a decongestant), antihypertensive drugs (blood pressure medications), quinolone antibiotics, pentobarbital or other barbiturates, beta-adrenergic agonists (asthma or heart drugs), disulfiram, flutamide, or dipyridamole. All of these have documented Moderate interactions with the cocoa in this chocolate.

Run your exact medications through the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in cocoa's heart benefits and don't take blood pressure medications, ephedrine, or certain antibiotics, this product is worth considering. If you take any prescription drugs — especially stimulants, heart medications, or antibiotics — check with us first.

And keep an eye on caffeine and sugar intake overall.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate, straight from the product label.

Brand ProCaps Laboratories
Barcode (UPC) 733191000DQ9
Net contents 120 Six-gram square(s); 25.4 Oz(s); 1.6 lb(s); 720 Gram(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 275202
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Piece(s)
Maximum serving Sizes:
2 Piece(s)
Servings per container
120
UPC/BARCODE
733191000DQ9
IngredientAmount% DV
Calories25 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Cholesterol0 mg--
Added Sugars2 Gram(s)4%
Total Sugars2 Gram(s)--
Total Fat2 Gram(s)3%
Saturated Fat1 Gram(s)5%
Trans Fat0 Gram(s)--
Dietary Fiber1 Gram(s)2%
natural Plant Sterol Esters650 mg--
Cocoa Flavanols40 mg--

Other ingredients: organic 66% Cacao Dark Chocolate, organic Coffee

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use for optimum cholesterol reduction, consume one or two CHOCONUVO Cafe squares with each meal (with no less than two meals daily). Other than pure enjoyment, there is no need to consume more than five squares daily for cholesterol reduction. CHOCONUVO Cafe should be consumed shortly before, during or after meals. Best results are achieved when combined with a healthy, low cholesterol, high fiber diet. Like any creamy chocolate, CHOCONUVO melts when exposed to heat. Should this occur, simply place it in the refrigerator and it will solidify back to its normal state. CHOCONUVO is perfect for baking, since its flavor and health benefits are not affected by exposure to heat. For questions about the use of this product called 800.332.7799.

Storage

Like any creamy chocolate, CHOCONUVO melts when exposed to heat. Should this occur, simply place it in the refrigerator and it will solidify back to its normal state.

Formula

Note. The coffee granules in CHOCONUVO Cafe only add a minimal amount of caffeine per square (less than 5 mg).

66% cacao mild dark chocolate

Mother nature's dynamic duo of heart health. CHOCONUVO Cafe Combines the heart-healthy benefits of dark chocolate with mother nature's most powerful and clinically proven cholesterol-reducing ingredient (plant sterols), along with the rich flavor of organic fair trade coffee. Naturally occurring compounds in dark chocolate called flavanols have long been known to promote heart and circulatory health. The unique combination of our natural plant sterols with our flavonol-rich organic mild dark chocolate creates the creamiest and most luxurious "milk chocolate-like" dark chocolate you will ever taste with the perfect hint of coffee crunch and coffee flavor. CHOCONUVO is also the first chocolate experience that naturally lowers cholesterol.

Chocolate - respected for thousands of years. Cocoa was revered by ancient South and Central American cultures. In fact, Aztec emperor Montezuma proclaimed cocoa a divine beverage that fights fatigue while Spanish explorer Hernando Cortes praised its benefits for physical endurance. For centuries, cocoa was not merely a source of nourishment, but of resilience, stamina and well-being. The scientific name for the cacao tree translates as God’s drink. As admired as cocoa was by Native Americans, it is not surprising that it soon became equally prized in the 16th century new world.

A unique dark chocolate experience. In recent years, due to its myriad health benefits, interest in dark chocolate has exceeded that of milk chocolate. Dark chocolate provides higher levels of healthy flavanols than milk chocolate and also contains less sugar, fat and calories, along with no added milk. It is this uniquely high level of flavanols that imparts dark chocolates rich flavor and health benefits, but also causes its drier texture. CHOCONUVO Cafes unique marriage of dark chocolate and coffee granules and cholesterol-lowering plant sterols creates an exceptionally healthy dark chocolate treat that melts in your mouth like milk chocolate. In fact, our mild CHOCONUVO Café 66 was specifically created for those who enjoy the flavor and health benefits of dark chocolate, but prefer the mild taste and creamy mixture of milk chocolate, along with a hint of coffee flavor and texture.

Dark chocolate and plant sterols: A natural solution to an unhealthy problem. The normal American diet increases cholesterol levels and the risk of heart disease. As a result, millions of Americans take cholesterol-lowering drugs with their long list of harmful side effects. If you and your physicians seek a natural tool to lower cholesterol, then CHOCONUVO Café is an ideal solution. We add the clinically proven cholesterol-lowering benefits of plant sterols to our heart-healthy organic 66% coffee-flavored mild dark chocolate. In fact, the 1,300 mg of plant sterols in just two CHOCONUVO Café squares is all you need to powerfully impact your cholesterol levels.

Ingredients Organic fair trade dark chocolate (Organic fair trade cacao beans, organic evaporated cane syrup, organic fair trade cocoa butter, organic sunflower lecithin) Cholestacare natural plant sterol esters and organic fair trade coffee beans.

According to US Food and Drug administration, consuming at least 650 mg of plant sterol esters twice daily with meals for a daily total intake of at least 1,300 MG as part of a healthy diet low in saturated fat cholesterol, may reduce the risk of heart disease. Each CHOCONUVO Café square supplies 650 mg of plant sterol esters.

Precautions

Made with machinery that may also process foods containing peanuts, tree nuts and milk.

General Statements

Unsurpassed. Purity. Quality. Integrity. Effectiveness. Andrew Lessman Founder of ProCaps Labs HSN www.HSN.com 800.944.9999 www.QVC.com 800.345.1515 Questions? Call 800.800.1200 www.ProCapslabs.com

Fair trade

All-solar manufacturing

Brand IP Statement(s)

Copyright 2021 ProCaps Labs Uniquely heart-healthy chocolate

Formulation

Organic

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Piece(s) Dosage formOther (e.g. Tea Bag) Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
1 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Natural Plant Sterol Esters

650 mg per serving

Cocoa Flavanols

Interacts with
661 drugs
40 mg per serving

Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are...

Cocoa Flavanols monograph & interactions

Other (inactive) ingredients: Organic 66% Cacao Dark Chocolate, Organic Coffee. These complete the product’s ingredient list but are not active constituents.

Interaction report

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories Drug Interactions

Want to check YOUR meds against ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,086Drugs
657 Moderate 1,429 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Cocoa Flavanols 661

Individual Drug Interactions

The ingredients in ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate interact with 2,086 drugs. Click any drug to see the details.

2 of the 3 ingredients in ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Cocoa Flavanols

Each ingredient & the kinds of drugs it affects

For each ingredient in ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Cocoa Flavanols37 drug types · 661 drugs

Ace Inhibitors (Aceis)

Theoretically, taking cocoa with ACEIs might increase the risk of adverse effects.
Human research shows that dark chocolate can inhibit ACE. Additionally, prolonged angioedema in an elderly patient on an ACE inhibitor was precipitated with intake of diabetic chocolate.

Likelihood Possible Evidence D
Adenosine (Adenocard)

Theoretically, cocoa might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Possible Evidence B
Alcohol (Ethanol)

Theoretically, concomitant use might increase levels and adverse effects of caffeine.
Cocoa contains caffeine. Alcohol reduces caffeine metabolism. Concomitant use of alcohol can increase caffeine serum concentrations and the risk of caffeine adverse effects.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research shows that intake of cocoa can inhibit platelet adhesion, aggregation, and activity and increase aspirin-induced bleeding time. For patients on dual antiplatelet therapy, cocoa may enhance the inhibitory effect of clopidogrel, but not aspirin, on platelet aggregation.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that cocoa can modestly decrease blood pressure in hypertensive and normotensive patients.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.
Cocoa contains caffeine. Theoretically, large amounts of caffeine might increase cardiac inotropic effects of beta-agonists. A case of atrial fibrillation associated with consumption of large quantities of chocolate in a patient with chronic albuterol inhalation abuse has also been reported.

Likelihood Probable Evidence D
Cytochrome P450 1A2 (Cyp1A2) Inhibitors

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from cocoa and increase caffeine levels.

Likelihood Possible Evidence D
Dipyridamole (Persantine)

Theoretically, cocoa might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
Cocoa contains caffeine. In human research, disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using cocoa with diuretic drugs might increase the risk of hypokalemia.
Cocoa contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Cocoa contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Flutamide (Eulexin)

Theoretically, cocoa might increase the levels and adverse effects of flutamide.
Cocoa contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide.

Likelihood Possible Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt cocoa withdrawal might increase the levels and adverse effects of lithium.
Cocoa contains caffeine. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Cocoa contains caffeine. Large amounts of caffeine with MAOIs might precipitate a hypertensive crisis.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Cocoa contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, cocoa might decrease the effects of pentobarbital.
Cocoa contains caffeine. Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Cocoa contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, cocoa might reduce the effects of phenytoin and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Quinolones (also referred to as fluoroquinolones) decrease caffeine clearance.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Cocoa contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2, and concomitant use might reduce metabolism of one or both agents.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, concomitant use might increase stimulant adverse effects.
Cocoa contains caffeine. Concomitant use might increase the risk of stimulant adverse effects.

Likelihood Probable Evidence C
Theophylline

Theoretically, cocoa might increase the levels and adverse effects of theophylline.
Cocoa contains caffeine. Large amounts of caffeine might inhibit theophylline metabolism. Caffeine decreases theophylline clearance 23% to 29%.

Likelihood Probable Evidence B
Cocoa Flavanols full monograph & all 37 interactions
The maker

Brand information

Manufacturer and brand details for ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate, from the product label.

ProCaps Laboratories

See all ProCaps Laboratories products
Name
ProCaps Labs
City
Henderson
State
NV
ZipCode
89011
Phone Number
800-800-1200
Web Address
ProCapsLabs.com
Pharmacist Counseling Corner

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories: Common Questions

Does ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate by ProCaps Laboratories interact with any medications?
Yes. Based on its ingredients, ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate has a known interaction with 2,086 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does cocoa flavanol chocolate actually help your heart?
The evidence says cocoa flavanols are possibly effective for cardiovascular disease — meaning there's real support, but it's not ironclad. Cocoa can modestly lower blood pressure, which is a genuine heart benefit. But if you take blood pressure medications, this effect could matter, so talk to your pharmacist first.
Is it safe to eat this chocolate while breastfeeding?
The safety data says cocoa is possibly safe during breastfeeding, but caffeine does pass into breast milk. Keep your intake modest and watch your baby for fussiness or trouble sleeping. If you're concerned, check with your doctor.
What side effects might I get from eating this chocolate?
Most people tolerate it fine, but digestive issues are the most common — bloating, gas, constipation, nausea, or heartburn. A faster heartbeat is rare. Allergic skin reactions happen occasionally. If you notice any of these, cut back or stop.
Is this safe during pregnancy?
The safety data is mixed — cocoa is rated possibly safe and possibly unsafe for pregnancy. That means we don't have enough clear evidence to say for sure. Talk with your doctor or pharmacist about whether it's right for you in pregnancy.
Why does the product label say to avoid concentrated cocoa supplements?
Because cocoa contains caffeine and related stimulants. A chocolate bar is a normal food dose, but concentrated supplements can deliver much more caffeine and pose a bigger risk — especially if you take other medications. Stick to food amounts unless your doctor says otherwise.
Does this chocolate actually help with stretch marks?
The evidence suggests it probably won't help stretch marks. That's one of the uses cocoa flavanols have been tested for, and the results don't support it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate label
Go deeper

The Full Monographs Behind ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Cocoa

Interacts with 661 drugs

Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are high in sugar, fat, and calories, which...

Read the full Cocoa monograph →
Sources

Sources & How We Checked

ChocoNuvo Cafe 66% Cacao Mild Dark Chocolate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 137 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
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  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Cocoa 119 references
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See these in context on the Cocoa monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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