Cholesterol Support Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cholesterol Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cholesterol Support is a dietary supplement by Best Naturals with 7 active ingredients. Its ingredients are commonly taken for high cholesterol, heart and blood vessel health, leg pain from poor circulation (intermittent claudication).Based on those ingredients, 1,269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guggulipid, Niacin, Red Rice Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cholesterol Support by Best Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Cholesterol Support by Best Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cholesterol Support by Best Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Cholesterol Support contains 7 active ingredients: policosanol (a waxy compound from sugarcane), beta-glucan (a type of fiber), guggulipid (a resin extract), red rice extract, beta-sitosterol (a plant sterol), niacin (a B vitamin), and soy isoflavones. These work through different pathways — some help manage cholesterol and triglycerides, others support blood vessel health and blood pressure.
The product also contains inactive ingredients: dicalcium phosphate, cellulose, croscarmellose sodium, stearic acid, silica, stearate, and pharmaceutical glaze.
Does it work?
Strong evidence
The evidence for this product's ingredients varies. Policosanol is likely effective for intermittent claudication (leg pain with activity), though evidence for coronary heart disease and familial high cholesterol is insufficient.
Beta-glucan is likely effective for cholesterol problems and heart disease risk. Guggulipid shows insufficient evidence for cholesterol or acne, and may even be possibly ineffective for weight loss.
Beta-sitosterol is likely effective for prostate health and possibly effective for familial high cholesterol and heart disease. Niacin is likely effective for pellagra (a rare B-vitamin deficiency disease) and possibly effective for cholesterol in people with HIV/AIDS or metabolic syndrome.
Red Rice Extract and Soy Isoflavones lack effectiveness ratings in our data.
How safe is it?
Well-documented data
Most of these ingredients are generally well tolerated at typical doses. Policosanol may cause headache, insomnia, dizziness, or upset stomach in some people, and weight loss has been reported though it's uncommon.
Guggulipid commonly causes digestive upset (belching, bloating, diarrhea, nausea) and skin reactions (rash, itching) — these are dose-dependent, with higher doses carrying greater risk. Rarely, guggulipid has been linked to muscle breakdown (rhabdomyolysis).
Niacin frequently causes flushing (up to 70% of users), especially at higher doses, plus gastrointestinal effects; rarely it can damage the liver. Beta-sitosterol may cause constipation, diarrhea, gas, indigestion, nausea, or loss of appetite.
Regarding pregnancy, policosanol, guggulipid, and beta-sitosterol should be avoided — there isn't enough safety data. Niacin in normal dietary amounts and prenatal vitamin doses is fine, but high-dose supplements should be avoided unless prescribed.
For breastfeeding, policosanol and guggulipid should be avoided; niacin is fine at normal dietary levels; beta-glucan and beta-sitosterol lack sufficient breastfeeding data. Soy Isoflavones and Red Rice Extract have no pregnancy/breastfeeding information on file.
Meds to double-check
Moderate interaction found
Before you start, check your list against these medication types: blood thinners and antiplatelet drugs (warfarin, aspirin, clopidogrel), beta-blockers, blood pressure medications, diabetes drugs, statins, gout medications (allopurinol, probenecid), nitroprusside, diltiazem, thyroid hormones, birth control pills and estrogens, tamoxifen, and immunosuppressants. Use the medication checker on this page to verify your exact drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines several ingredients with documented effects on cholesterol and heart health, but the evidence is mixed and side effects are possible. If you take any blood pressure medication, blood thinner, diabetes drug, statin, or gout medication, check your specific prescriptions with the tool below before starting — the interactions are real.
Talk to your pharmacist, especially if you're pregnant, nursing, or taking multiple medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cholesterol Support, straight from the product label.
| Brand | Best Naturals |
|---|---|
| Barcode (UPC) | 817716010250 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jan 24, 2024 |
| DSLD ID | 305994 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cholesterol Support by Best Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Policosanol | 3 mg | -- |
| Beta-Glucan | 50 mg | -- |
| Guggulipid | 1000 mg | -- |
| Red Rice Extract | 700 mg | -- |
| Beta-Sitosterol | 300 mg | -- |
| Niacin | 20 mg NE | 125% |
| Soy Isoflavones | 60 mg | -- |
Other ingredients: Dicalcium Phosphate, Cellulose, Croscarmellose Sodium, Stearic Acid, Silica, Stearate, Pharmaceutical Glaze
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Cholesterol Support is a dietary supplement specifically formulated to support your body's natural metabolism of cholesterol and a healthy cardiovascular system. In addition to taking Best Naturals Cholesterol Support, we recommend a diet low in saturated fats and regular aerobic exercise. Certain research publications indicate that Cholesterol Support may help support the following: Supports healthy cholesterol & triglyceride level. Supports heart health.
Premium Formula 3rd Party lab tested
No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no corn, no egg, no lactose, no gluten, no wheat, no yeast, no fish.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take two (2) tablets daily before a meal, or as directed by your qualified healthcare professional.
Precautions
Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of the reach of children.
Do not use if safety seal is broken or missing.
Allergen Warning: Contains Soy (Beta-Sitosterol).
Storage
Keep in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Made In USA
GMP Good Manufacturing Practice Product
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cholesterol Support by Best Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cholesterol Support by Best Naturals
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Policosanol
Interacts with242 drugs
Policosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to low...
Policosanol monograph & interactionsBeta-Glucan
Interacts with293 drugs
Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...
Beta-Glucan monograph & interactionsGuggulipid
Interacts with757 drugs
Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...
Guggulipid monograph & interactionsRed Rice Extract
Interacts with477 drugs
Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Be...
Red Rice Extract monograph & interactionsBeta-Sitosterol
No knowninteractions
Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Eviden...
Beta-Sitosterol monograph & interactionsNiacin
Interacts with727 drugs
Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...
Niacin monograph & interactionsSoy Isoflavones
Other (inactive) ingredients: Dicalcium Phosphate, Cellulose, Croscarmellose Sodium, Stearic Acid, Silica, Stearate, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.
Cholesterol Support by Best Naturals Drug Interactions
HelloPharmacist Interaction Report
Cholesterol Support by Best Naturals contains several ingredients that interact with medications.
The most serious concern is policosanol, which has moderate-severity interactions with blood thinners (anticoagulants and antiplatelets) like warfarin — it may increase your risk of bruising and bleeding. Policosanol also interacts moderately with beta-blockers, blood pressure drugs, diabetes medications, and nitroprusside, potentially making their effects stronger.
Read the full breakdown — every affected drug type, severity by severity
Guggulipid carries moderate interactions with a wide range of drugs: it can reduce the effectiveness of propranolol and diltiazem, interfere with how your liver processes certain medications (CYP3A4 substrates), reduce birth control and hormone therapy effectiveness, increase bleeding risk with blood thinners, raise thyroid hormone levels unpredictably, and interfere with tamoxifen. Beta-glucan may increase the blood pressure-lowering effect of blood pressure medications and could theoretically interfere with immunosuppressant drugs.
Niacin has moderate interactions with blood pressure drugs, blood thinners, diabetes medications, statins, gout medications (allopurinol and probenecid), liver-toxic drugs, and bile acid sequestrants — if you take a sequestrant, separate niacin by 4–6 hours.
Beta-sitosterol, when checked, shows no interactions documented in our data. Red Rice Extract and Soy Isoflavones were not checked — we hold no interaction data for them.
Altogether, these interactions span 1,228 individual medications. Use the medication checker on this page to look up your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cholesterol Support?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cholesterol Support interact with 1,269 drugs. Click any drug to see the details.
5 of the 7 ingredients in Cholesterol Support interact with drugs. Each result below shows which ingredient is responsible. Guggulipid Niacin Red Rice Extract Beta-Glucan Policosanol
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
Red Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Phenylephrine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorzoxazone interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
Red Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Chlorzoxazone, Codeine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Codeine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
Red Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Codeine, Doxylamine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Codeine, Methocarbamol interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
Red Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dextromethorphan interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
Red Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
GuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Cholesterol Support — through 3 ingredients. Tap an ingredient for the detail:
Red Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionGuggulipidCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dichloralantipyrine, Isometheptene interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dichloralphenazone, Isometheptene interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dichlorophenazone, Isometheptane interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
Red Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Diphenhydramine interactionNiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Cholesterol Support — through 2 ingredients. Tap an ingredient for the detail:
NiacinHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionRed Rice ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Rice Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cholesterol Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Guggulipid
Anticoagulant/Antiplatelet Drugs
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.
Contraceptive Drugs
Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.
Diltiazem (Cardizem, Others)
Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.
Estrogens
Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.
Propranolol (Inderal)
Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.
Rosuvastatin (Crestor)
Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.
Tamoxifen (Nolvadex)
Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Thyroid Hormone
Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.
Niacin
Alcohol (Ethanol)
Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.
Allopurinol (Zyloprim)
Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.
Anticoagulant/Antiplatelet Drugs
Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.
Antidiabetes Drugs
Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.
Antihypertensive Drugs
Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.
Bile Acid Sequestrants
Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.
Gemfibrozil (Lopid)
Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.
Hepatotoxic Drugs
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.
Hmg-Coa Reductase Inhibitors ("Statins")
Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).
Probenecid (Benemid)
Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.
Sulfinpyrazone (Anturane)
Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.
Thyroid Hormone
Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.
Transdermal Nicotine (Nicoderm)
Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.
Warfarin (Coumadin)
There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.
Aspirin
Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.
Red Rice Extract
Cyclosporine (Neoral, Sandimmune)
Theoretically, taking red yeast rice in combination with cyclosporine might increase the risk of myopathy.
Red yeast rice contains varying levels of the statin drug lovastatin. Cyclosporine has been reported to increase plasma levels of lovastatin by 5- to 20-fold, resulting in reports of myopathy and rhabdomyolysis.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.
Red yeast rice contains varying levels of the statin drug lovastatin, which is metabolized by CYP3A4. Combining red yeast rice with CYP3A4 inhibitors might increase serum levels of lovastatin from red yeast rice.
Gemfibrozil (Lopid)
Theoretically, taking red yeast rice in combination with gemfibrozil might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin. Gemfibrozil has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.
Hepatotoxic Drugs
Theoretically, concomitant use might increase the risk of liver damage.
Red yeast rice contains varying levels of the drug lovastatin. Lovastatin can cause liver damage in some people. Some clinical research suggests that supplements containing red yeast rice might increase liver enzyme levels in some, but not all, participants. Cases of acute hepatitis have been associated with red yeast rice. Combining it with hepatotoxic drugs might further increase this risk.
Hmg-Coa Reductase Inhibitors ("Statins")
Theoretically, taking red yeast rice with other statins might increase the risk of potential adverse effects.
Red yeast rice contains varying levels of the statin drug lovastatin and might result in supratherapeutic levels when used with other statins. Based on evaluation of data from the US Food and Drug Administration's adverse event reporting system (FAERS), it is recommended that red yeast rice products be avoided in people taking prescription statins.
Niacin
Theoretically, taking red yeast rice in combination with high-dose niacin might increase the risk of rhabdomyolysis.
Red yeast rice contains varying levels of the statin drug lovastatin and has been linked to reports of myopathy. Niacin has been reported to increase the risk of rhabdomyolysis when used in combination with lovastatin.
Beta-Glucan
Antihypertensive Drugs
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.
Immunosuppressants
Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.
Policosanol
Anticoagulant/Antiplatelet Drugs
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. Although, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response. Furthermore, a study in patients undergoing percutaneous coronary intervention with a drug-eluting stent found that taking policosanol 40 mg plus clopidogrel and aspirin daily for 30 days modestly reduced the risk for minor bleeding events when compared with taking clopidogrel and aspirin alone. Until more is known, use with caution.
Antidiabetes Drugs
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Clinical research shows that policosanol can lower blood glucose levels.
Beta-Blockers
Concomitant use of policosanol with beta-blockers can cause additive blood pressure-lowering effects.
Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the blood-pressure lowering effects of propranolol.
Nitroprusside (Nitropress)
Theoretically, concomitant use of policosanol with nitroprusside might cause additive blood pressure-lowering effects.
Animal research shows that taking policosanol along with nitroprusside can increase the blood pressure-lowering effects of nitroprusside.
Propranolol (Inderal)
Animal research shows that taking policosanol along with propranolol can increase the blood pressure-lowering effects of propranolol.
Warfarin (Coumadin)
Theoretically, taking policosanol with warfarin might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response.
Brand information
Manufacturer and brand details for Cholesterol Support, from the product label.
Best Naturals
See all Best Naturals products- Name
- Best Naturals
- Street Address
- PO Box 394
- City
- Kenilworth
- State
- NJ
- ZipCode
- 07033
- Phone Number
- 1-877-659-6004
- Web Address
- www.shopbestnaturals.com
Cholesterol Support by Best Naturals: Common Questions
Does Cholesterol Support by Best Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does policosanol actually lower cholesterol?
Can I take this if I'm on a blood thinner like warfarin?
What are the most common side effects I might notice?
Is beta-sitosterol safe to combine with other medications?
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I have high blood pressure and take medication. Is this product safe for me?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cholesterol Support’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Policosanol
Interacts with 242 drugsPolicosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to lower cholesterol. Early studies from Cuba...
Read the full Policosanol monograph → Herb & supplement monographBeta-glucans
Interacts with 293 drugsBeta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...
Read the full Beta-glucans monograph → Herb & supplement monographGuggul
Interacts with 757 drugsGuggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...
Read the full Guggul monograph → Herb & supplement monographRed Yeast Rice
Interacts with 477 drugsRed yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') cholesterol. Because of this, it carries the same risks...
Read the full Red Yeast Rice monograph → Herb & supplement monographBeta-sitosterol
Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker...
Read the full Beta-sitosterol monograph → Herb & supplement monographNiacin
Interacts with 727 drugsNiacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...
Read the full Niacin monograph →Sources & How We Checked
Cholesterol Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 170 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Policosanol 15 references
- Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
- Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
- Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
- Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
- Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
- Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
- Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
- Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
- Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
- Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
- Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
- Fernandez L, Mas R, Illnait J, Fernandez JC. Policosanol: results of a postmarketing surveillance study of 27,879 patients. Curr Ther Res 1998;59(10):717-22. DOI
- Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
- Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
- Li C, Ding Y, Si Q, Li K, Xu K. Multiple functions of policosanol in elderly patients with dyslipidemia. J Int Med Res. 2020;48(7):300060520936082. PubMed
Beta-glucans 11 references
- Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
- Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
- Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
- Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
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