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Dietary supplement

Choline SR 300 mg Ingredients & Drug Interactions

by Endurance Products Company

Choline SR 300 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline SR 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline SR 300 mg is a dietary supplement by Endurance Products Company with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline SR 300 mg by Endurance Products Company

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline SR 300 mg by Endurance Products Company — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline SR 300 mg by Endurance Products Company

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline, a nutrient your body uses to make acetylcholine, a neurotransmitter involved in muscle and nerve function, and to support cell membrane health. Choline SR is a sustained-release formulation designed to deliver the ingredient gradually.

The tablet also contains inactive ingredients—vegetable wax, stearic acid, magnesium stearate, silica, and modified cellulose gum—that help form and preserve the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Choline's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: liver function, lipid metabolism, and nervous system health.
  • We looked for evidence on: Nonalcoholic fatty liver disease (NAFLD), Hepatitis, Cardiovascular disease (CVD), Cognitive function, Age-related cognitive decline, Dementia — and 4 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cardiovascular disease (CVD), Nonalcoholic fatty liver disease (NAFLD), Cognitive function, and more.

The evidence for choline in the areas we have data on is mixed. For athletic performance, the evidence suggests it's probably not effective.

For bronchitis, age-related cognitive decline, liver fat (in people on IV nutrition), hay fever, and Alzheimer disease, there isn't enough reliable evidence to rate whether it works. If you're considering this product for a specific condition, talk with your doctor or pharmacist about what the research actually shows for your situation.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline in food amounts is generally well tolerated. At high doses—especially above 3.5 grams daily—it can cause side effects.

The most common is a fishy body odor from how your intestines break down choline. At very high doses (9 grams or more daily), some people have reported diarrhea, nausea, salivation, sweating, and vomiting.

This 300 mg tablet is a low dose, but stacking multiple doses or combining it with other choline sources could push you toward those higher amounts. Choline is important during pregnancy and breastfeeding, but use supplements only at the dose your doctor recommends—not on your own.

There isn't enough data on file about safety at other doses in these situations, so talk with your healthcare provider about what's right for you.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take atropine, a medication that blocks certain nerve signals. Choline may reduce its effectiveness.

This is the documented interaction we hold data on for this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Choline SR might be worth considering if you're looking to support general cellular and nerve function, though the evidence for specific health claims is limited or absent. If you take atropine or any other prescription medication, check it against the tool on this page first, then talk with your doctor or pharmacist before you start.

The same goes if you're pregnant, breastfeeding, or thinking about combining this with other supplements.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline SR 300 mg, straight from the product label.

Brand Endurance Products Company
Barcode (UPC) 729135187201
Net contents 200 Tablet(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 259518
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline SR 300 mg by Endurance Products Company, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
6 Tablet(s)
Servings per container
33
UPC/BARCODE
729135187201
IngredientAmount% DV
Choline300 mg55%

Other ingredients: Vegetable Wax, Stearic Acid, Magnesium Stearate, Silica, modified Cellulose Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Choline SR provides an excellent source of choline, an essential nutrient for healthy liver function and lipid metabolism, cell membrane integrity, and heart and nervous system health.

Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are pregnant or nursing.

Keep out of reach of children.

Do not use if seal is broken or missing.

Storage

Store in a cool, dry place.

Formulation

Natural color variation occurs in tablets. Formulated for steady release over 5-7 hours.

Sustained release

Promotes liver and cellular health

No sugar, starch, artificial flavors, colors, sweeteners or preservatives.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) to six (6) tablets daily in divided doses, preferably with meals, or as directed by your healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline SR 300 mg by Endurance Products Company label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline SR 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline SR 300 mg by Endurance Products Company

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container33 Amounts shown are per serving.

Choline

Interacts with
16 drugs
300 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Vegetable Wax, Stearic Acid, Magnesium Stearate, Silica, Modified Cellulose Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline SR 300 mg by Endurance Products Company Drug Interactions

Want to check YOUR meds against Choline SR 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Choline SR 300 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Choline SR 300 mg interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline SR 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline SR 300 mg, from the product label.

Endurance Products Company

See all Endurance Products Company products
Name
Endurance Products Company
Street Address
PO Box 3810
City
Tualatin
State
OR
ZipCode
97062
Phone Number
1-800-483-2532
Web Address
www.endur.com
Pharmacist Counseling Corner

Choline SR 300 mg by Endurance Products Company: Common Questions

Does Choline SR 300 mg by Endurance Products Company interact with any medications?
Yes. Based on its ingredients, Choline SR 300 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline SR 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 300 mg of choline a high dose?
No, 300 mg is a modest dose. Side effects from choline typically happen at much higher intakes—the tolerable upper limit is 3.5 grams (3,500 mg) daily, and the most common side effect, a fishy body odor, is mainly reported at high doses. That said, avoid stacking multiple choline sources to stay below that ceiling.
Can I take this if I'm pregnant or breastfeeding?
Choline is important during both pregnancy and breastfeeding, but you should only take a supplement at the dose your doctor advises. Talk with your healthcare provider about what amount is right for you in your situation.
What does choline actually do in my body?
Choline is a nutrient your body uses to make acetylcholine, a chemical messenger in your nerves and muscles. It also supports the structure and function of cell membranes throughout your body.
Will this help my memory or mental sharpness?
The evidence for choline in age-related cognitive decline and Alzheimer disease is not strong enough to rate. If memory or brain health is your main goal, talk with your doctor about whether this product makes sense for you and what the research actually supports.
What's that fishy smell I've heard about with choline?
At high doses, choline can cause a fishy body odor because your intestines convert it into trimethylamine, which your body releases through sweat and breath. This is rare at lower doses like 300 mg, but it's something to be aware of if you're taking much larger amounts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Choline SR 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline SR 300 mg label
Go deeper

The Full Monographs Behind Choline SR 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline SR 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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