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Dietary supplement

Cinnamon Bark 500 mg Ingredients & Drug Interactions

by GNC Herbal Plus

Cinnamon Bark 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cinnamon Bark 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cinnamon Bark 500 mg is a dietary supplement by GNC Herbal Plus with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 442 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cinnamon, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cinnamon Bark 500 mg by GNC Herbal Plus

Ask about any prescription or over-the-counter medication and we check it for interactions with Cinnamon Bark 500 mg by GNC Herbal Plus — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cinnamon Bark 500 mg by GNC Herbal Plus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: cinnamon powder (the spice cinnamon, specifically cassia cinnamon) at 500 mg per capsule. The inactive ingredients are gelatin (the capsule), microcrystalline cellulose, stearic acid, silicon dioxide, and sodium lauryl sulfate — these are standard excipients that help form and deliver the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cassia Cinnamon product and its label doesn't state a use — see Cassia Cinnamon's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for cinnamon's effectiveness is not established in our data. Studies have looked at cassia cinnamon for amenorrhea (absent menstrual periods), angina (chest pain), common cold, diabetes, diarrhea, and high cholesterol, but the data we hold rates all of these as having insufficient reliable evidence to say whether it works.

If you're considering this supplement for any of those purposes, talk with your pharmacist or doctor about what the current research shows.

The evidence, ingredient by ingredient Cassia Cinnamon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cinnamon is generally safe in the amounts you'd eat as a spice, but supplement doses — especially high ones taken long-term — may harm the liver because of the coumarin it contains. In clinical trials, doses of 360 mg to 12 grams daily for 3 months did not significantly raise liver enzyme markers, but very large amounts over extended time remain a concern.

A small number of people have reported skin reactions (rash or eyelid dermatitis) after taking cinnamon supplements, and very rarely, a low blood sugar episode (hypoglycemic seizure) was reported, though it's unclear if cinnamon caused it. During pregnancy and breastfeeding, food amounts of cinnamon are likely safe, but avoid high-dose supplement forms because there isn't enough safety data.

Side effects, ingredient by ingredient Cassia Cinnamon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 443 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before taking it if you use hepatotoxic drugs (medications that can affect your liver) or antidiabetes drugs (medications for blood sugar). Both are Moderate interactions — your doctor or pharmacist may need to adjust monitoring or doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take medications for diabetes or liver conditions, or if you take any medication regularly, check your specific drugs with the tool on this page before starting. Cinnamon is generally tolerated at supplement doses, but long-term use of large amounts carries a theoretical liver risk.

Talk to your pharmacist if you have questions about whether this fits your health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cinnamon Bark 500 mg, straight from the product label.

Brand GNC Herbal Plus
Barcode (UPC) 048107129002
Net contents 200 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 297063
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cinnamon Bark 500 mg by GNC Herbal Plus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
200
UPC/BARCODE
048107129002
IngredientAmount% DV
Cinnamon, Powder500 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Sodium Lauryl Sulfate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using if you are pregnant, nursing, taking medication or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Herbal Supplement

Formulation

Traditional Ayurvedic herb Whole herb

No sugar, no artificial colors, no artificial flavors,sodium free, no wheat, gluten free, no corn, no soy, no dairy.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cinnamon Bark 500 mg by GNC Herbal Plus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cinnamon Bark 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cinnamon Bark 500 mg by GNC Herbal Plus

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

Cinnamon, Powder

Interacts with
442 drugs
500 mg per serving Form: Cinnamomum burmannii, Powder, Cinnamomum cassia, Powder

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evi...

Cinnamon, Powder monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Sodium Lauryl Sulfate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cinnamon Bark 500 mg by GNC Herbal Plus Drug Interactions

Want to check YOUR meds against Cinnamon Bark 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
442Drugs
442 Moderate

Ingredients driving the most interactions

Cinnamon, Powder 442

Individual Drug Interactions

The ingredients in Cinnamon Bark 500 mg interact with 442 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cinnamon Bark 500 mg interact with drugs. Each result below shows which ingredient is responsible. Cinnamon, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Cinnamon Bark 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cinnamon, Powder2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cinnamon Bark 500 mg, from the product label.

GNC Herbal Plus

See all GNC Herbal Plus products
Name
GNC Holdings, LLC
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
GNC.com
Pharmacist Counseling Corner

Cinnamon Bark 500 mg by GNC Herbal Plus: Common Questions

Does Cinnamon Bark 500 mg by GNC Herbal Plus interact with any medications?
Yes. Based on its ingredients, Cinnamon Bark 500 mg has a known interaction with 442 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cinnamon Bark 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this cinnamon supplement lower my blood sugar?
Cassia cinnamon may lower blood glucose in theory, and there's concern it could add to the effect of diabetes medications you take. The evidence for it actually working for diabetes isn't established in our data, so don't rely on it alone. If you take blood sugar medication, check with your pharmacist before adding this.
Is it safe to take this long-term?
In clinical trials at supplement doses (360 mg to 12 grams daily for 3 months), cinnamon didn't significantly raise liver markers. But there's some concern that very large amounts over a long time might stress the liver because cinnamon contains coumarin. Stick to the label dose and talk with your pharmacist if you plan to take it for months on end.
Can I take this while pregnant or breastfeeding?
Food amounts of cinnamon are likely safe during pregnancy and breastfeeding. But avoid high-dose supplement forms like this one — there isn't enough safety data for concentrated doses. Talk with your doctor or pharmacist for personalized advice.
What's in the capsule besides the cinnamon?
The capsule itself is gelatin, and it also contains microcrystalline cellulose, stearic acid, silicon dioxide, and sodium lauryl sulfate — these are all standard ingredients that help form and stabilize the capsule. They're inert fillers and binders.
Has this been studied for any health conditions?
Cassia cinnamon has been studied for amenorrhea, angina, common cold, diabetes, diarrhea, and high cholesterol. The evidence we hold rates all of these as insufficient to say whether it works, so the science isn't clear yet for any of those uses.
Are there any side effects?
Most people tolerate cinnamon well at supplement doses. Rarely, people have reported skin reactions like rash or eyelid dermatitis. One person in a trial had a low blood sugar episode, though it's unclear if cinnamon caused it. Talk with your pharmacist if you develop any unusual symptoms.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cinnamon Bark 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cinnamon Bark 500 mg label
Go deeper

The Full Monographs Behind Cinnamon Bark 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph →
Sources

Sources & How We Checked

Cinnamon Bark 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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