Cognizin Citicoline 250 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cognizin Citicoline 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cognizin Citicoline 250 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for memory and thinking, brain health and aging, stroke recovery support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Cognizin Citicoline 250 mg by The Vitamin Shoppe
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has one active ingredient: Cognizin Citicoline, a form of citicoline (also called CDP-choline), which is a compound your body makes naturally and uses in cell membrane function and brain chemistry. The capsule itself contains rice flour, vegetable cellulose, and calcium palmitate as inactive ingredients.
Does it work?
Moderate evidence
The evidence for citicoline is mixed depending on what you're taking it for. It's possibly effective for age-related cognitive decline and glaucoma — meaning there's some research support, but the data isn't rock-solid yet.
For stroke, the evidence currently points toward it being possibly ineffective. For Alzheimer's disease, traumatic brain injury, and cardiac arrest, there simply isn't enough reliable evidence to say whether it works or not.
How safe is it?
Well-documented data
Citicoline is generally well tolerated in studies, though long-term safety hasn't been fully worked out yet. The most common side effects reported when taken by mouth are abdominal pain, back pain, blurred vision, constipation, diarrhea, swelling, headache, insomnia, nausea, and rash — but these showed up in only a small number of trial participants.
Safety data during pregnancy and breastfeeding isn't strong enough to be confident, so it's best to avoid this supplement if you're pregnant or nursing.
Meds to double-check
No known interactions
No interactions are documented in our data for citicoline with any medications. That's good news, but run your full medication list past your pharmacist before you start just to be safe.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Cognizin Citicoline might be worth considering if you're interested in supporting cognition as you age or managing glaucoma, since there's some research backing those uses. If you're pregnant, breastfeeding, or have any health concerns, talk with your doctor or pharmacist first — they can help you weigh whether this makes sense for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cognizin Citicoline 250 mg, straight from the product label.
| Brand | The Vitamin Shoppe |
|---|---|
| Barcode (UPC) | 766536035977 |
| Net contents | 60 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 22, 2019 |
| DSLD ID | 208874 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cognizin Citicoline 250 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cognizin Citicoline | 250 mg | -- |
Other ingredients: Rice Flour, Vegetable Cellulose, Calcium Palmitate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Cognitive Health Mental Focus
Non-GMO Gluten-Free Dairy-Free Soy-Free Nut-Free Does not contain: Gluten, Sugar, Salt, Preservatives, Artificial Colors or Flavors.
General Statements
Specialty
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These products have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Suggested/Recommended/Usage/Directions
Directions: Take one (1) vegetable capsule up to two (2) times daily, preferably with meals.
Precautions
Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.
Keep out of reach of children.
Tamper evident Do not use if outer seal is broken or missing.
Formula
Citicoline is a naturally occurring intermediate involved in the synthesis of phosphatidylcholine, a major constituent of the grey matter of the brain. Citicoline also promotes the synthesis of acetylcholine, a key brain neurotransmitter.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
Cognizin is a registered trademark of Kyowa Hakko Bio Co., Ltd.
Seals/Symbols
Quality promise Tested & trusted
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cognizin Citicoline 250 mg by The Vitamin Shoppe label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cognizin Citicoline 250 mg by The Vitamin Shoppe
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.
Cognizin Citicoline
No knowninteractions
Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...
Cognizin Citicoline monograph & interactionsOther (inactive) ingredients: Rice Flour, Vegetable Cellulose, Calcium Palmitate. These complete the product’s ingredient list but are not active constituents.
Cognizin Citicoline 250 mg by The Vitamin Shoppe Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Cognizin Citicoline 250 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Cognizin Citicoline 250 mg, from the product label.
The Vitamin Shoppe
See all The Vitamin Shoppe products- Name
- Vitamin Shoppe, Inc.
- City
- Secaucus
- State
- NJ
- ZipCode
- 07094
- Phone Number
- 1-866-293-3367
- Web Address
- www.vitaminshoppe.com
Cognizin Citicoline 250 mg by The Vitamin Shoppe: Common Questions
Does Cognizin Citicoline 250 mg by The Vitamin Shoppe interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is Cognizin Citicoline, and what's it supposed to do?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
Does this work for Alzheimer's disease or stroke?
Are there any fillers or other ingredients in the capsule?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cognizin Citicoline 250 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cognizin Citicoline 250 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cognizin Citicoline 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Citicoline 11 references
- Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
- Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
- Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
- Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
- Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
- Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
- Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
- Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
- Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
- Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
- Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC