Comfort Ingredients & Drug Interactions
by GNC TriFlex
What is this page for?
First and foremost: checking Comfort against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Comfort is a dietary supplement by GNC TriFlex with 3 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Comfort by GNC TriFlex
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
GNC TriFlex Comfort contains three active ingredients: undenatured Type II Collagen, Hyaluronic Acid, and UC-II(R) natural Collagen concentrate. These are designed to support joint comfort and skin health.
The product also contains inactive ingredients — Dicalcium Phosphate, Cellulose, Titanium Dioxide, Vegetable Acetoglycerides, and Riboflavin — which function as binders, fillers, and other structural components.
Does it work?
Not established
The evidence we hold is mixed. Hyaluronic Acid is rated possibly effective for dry eye and venous leg ulcers (leg wounds from poor circulation).
For aging skin, hay fever, and sexual dysfunction, the evidence is insufficient to draw a clear conclusion either way. We don't have effectiveness data on file for the collagen ingredients in this product, so we can't speak to how well they work for joint or skin support based on what we hold.
How safe is it?
Well-documented data
Hyaluronic Acid is generally well tolerated when taken orally, though long-term safety of supplements hasn't been fully studied. The safety data advises caution: there isn't enough long-term information, so it's best to take oral hyaluronic acid only if your doctor recommends it.
When applied to skin, it's been reported to rarely cause eczema, itching, redness, or wound infection. Eye drops containing hyaluronic acid have very rarely caused eye pain.
We don't have safety data on file for the collagen ingredients.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That doesn't mean interactions can't occur — just that we have no interaction data on file for them.
Run your exact medications through the checker on this page, or ask your pharmacist before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
If you're looking to support joint comfort or skin health and want to try a collagen-based supplement, GNC TriFlex Comfort has no documented drug interactions for the ingredient we could assess. That said, long-term safety data on hyaluronic acid supplements is limited, so it's worth talking to your pharmacist before you start — especially if you have any skin conditions or eye sensitivity.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Comfort, straight from the product label.
| Brand | GNC TriFlex |
|---|---|
| Barcode (UPC) | 048107118037 |
| Net contents | 30 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2013 |
| DSLD ID | 19435 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Comfort by GNC TriFlex, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| undenatured Type II Collagen | 10 mg | -- |
| Hyaluronic Acid | 5 mg | -- |
| Fast-Acting Comfort Blend | 250 mg | -- |
| UC-II(R) natural Collagen concentrate | 40 mg | -- |
Other ingredients: Dicalcium Phosphate, Cellulose, Titanium Dioxide, Vegetable Acetoglycerides, Riboflavin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
-Feel significant improvement in joint discomfort in just days^* -Soothes achy joints and improves joint function by 19%^* -Cushions sore joints with just one small pill per day*
^In a 12 week multi-center, randomized, double-blind, placebo-controlled study of 60 adults, subjects taking 250 mg/day of the GNC TriFlex(TM) Fast-Acting Comfort Blend showed a significant 29.8% improvement in joint flexibility and a 19.4% improvement in joint function in 30 days compared to subjects on placebo. *Compared to a leading brand.
79% SMALLER PILL*
Suggested/Recommended/Usage/Directions
ONE PER DAY
Directions: As a dietary supplement, take one tablet daily.
Precautions
WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.
Discontinue use two weeks prior to surgery.
KEEP OUT OF REACH OF CHILDREN.
Formulation
No Artificial Colors, No Artificial Flavors, No Preservatives, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free.
Brand IP Statement(s)
UC-II(R) is a registered trademark of InterHealth N.I.
Seals/Symbols
UC-II(R)
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General
CODE 281912 GNG
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Comfort by GNC TriFlex label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Comfort by GNC TriFlex
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Hyaluronic Acid
No knowninteractions
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...
Hyaluronic Acid monograph & interactionsFast-Acting Comfort Blend
UC-II(R) natural Collagen concentrate
- › Undenatured Type II Collagen
Other (inactive) ingredients: Dicalcium Phosphate, Cellulose, Titanium Dioxide, Vegetable Acetoglycerides, Riboflavin. These complete the product’s ingredient list but are not active constituents.
Comfort by GNC TriFlex Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Comfort. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Comfort, from the product label.
GNC TriFlex
- Phone Number
- 1-888-462-2548
Comfort by GNC TriFlex: Common Questions
Does Comfort by GNC TriFlex interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is undenatured Type II Collagen, and does it work?
Is hyaluronic acid safe to take by mouth?
Does hyaluronic acid actually help with aging skin?
Can hyaluronic acid cause side effects?
Is this product safe during pregnancy or while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Comfort is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Comfort’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Comfort's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Hyaluronic Acid 4 references
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
- U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
- Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
- Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC