CompleteGest Ingredients & Drug Interactions
by Nature's Way
What is this page for?
First and foremost: checking CompleteGest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CompleteGest is a dietary supplement by Nature's Way with 13 active ingredients. Its ingredients are commonly taken for improving mineral absorption, breaking down phytic acid (phytate) in grains and legumes, supporting digestion of plant-based foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of CompleteGest by Nature's Way
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
CompleteGest contains 13 active ingredients, all digestive enzymes. You've got amylase and phytase (which break down carbohydrates and plant compounds), four different proteases (protease I, II, III, and IV — they break down proteins), two lipases (which break down fats), two cellulases (which break down fiber), sucrase (which breaks down sucrose), and two lactases (which break down the milk sugar lactose).
The capsule itself is made from hypromellose, cellulose, and magnesium stearate.
Does it work?
Strong evidence
The data we hold shows that lactase is effective for lactose intolerance — that one's well established. For the other ingredients — phytase, the proteases, lipases, cellulases, amylase, and sucrase — the evidence isn't established in our records.
Most have insufficient reliable evidence to rate them for the conditions they're used for.
How safe is it?
Well-documented data
The proteases and phytase are generally well tolerated in supplement form, though some people report digestive upset or allergic reactions. Occupational exposure to airborne phytase and protease powder can trigger allergic asthma or a lung condition called hypersensitivity pneumonitis (an immune reaction in the lungs), but that's from inhaled powder — not oral supplements.
Lipase and lactase also appear generally well tolerated in adults at usual doses. Rare allergic reactions to lactase powder have been reported in workers exposed to airborne particles.
We don't have enough safety data to advise on phytase or the proteases in pregnancy — the facts say to avoid them unless your doctor says otherwise. For lipase, there's limited data in pregnancy; check with your doctor.
Lactase is likely safe in pregnancy. During breastfeeding, phytase and protease use isn't recommended without medical advice.
For lipase and lactase, safety data during breastfeeding are limited — talk to your healthcare provider first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Check your specific medications below to be sure.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This product is a multi-enzyme digestive blend. Lactase in it is proven to help with lactose intolerance; the others lack strong evidence for their listed uses.
It's generally well tolerated, but if you're pregnant, breastfeeding, or have a serious digestive condition, talk to your pharmacist or doctor before you take it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 9 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CompleteGest, straight from the product label.
| Brand | Nature's Way |
|---|---|
| Barcode (UPC) | 750856600182 |
| Net contents | 180 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2025 |
| DSLD ID | 333715 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CompleteGest by Nature's Way, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Protease I | 0 NP | -- |
| Protease II | 0 NP | -- |
| Cellulase I | 0 NP | -- |
| Enzymes | 281 mg | -- |
| Sucrase | 0 NP | -- |
| Cellulase II | 0 NP | -- |
| Protease III | 0 NP | -- |
| Protease IV | 0 NP | -- |
| Lipase I | 0 NP | -- |
| Lipase II | 0 NP | -- |
| Lactase I | 0 NP | -- |
| Lactase II | 0 NP | -- |
Other ingredients: Hypromellose, Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Mealtime enzyme formula CompleteGest with amylase, protease, lactase, and lipase
Vegan enzymes to support digestion
Formulation
Supports digestion of carbohydrate, fat, protein, and fiber Multi-enzyme blend to help digest food
No dairy, gelatin, or artificial colors or flavors. Vegan Gelatin free
Vegan Gelatin free
Bottled and tested in the USA
Vegan enzymes to support digestion
General Statements
Explore more products at naturesway.com Made from 50% post-consumer recycled plastic
Precautions
Keep out of reach of children.
Safety sealed with inner seal. Do not use if seal is broken or missing.
Caution: If you are pregnant, nursing, have diabetes, or if you are taking any medications, consult a healthcare professional before use.
Storage
Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
Seals/Symbols
Vegan Gelatin free
Brand IP Statement(s)
Copyright 2024
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Adults take 1 capsule with meals up to six times daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CompleteGest by Nature's Way label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CompleteGest by Nature's Way
These are the 13 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Enzymes
- › Amylase
- › Phytase
- › Protease I
- › Protease II
- › Cellulase I
- › Sucrase
- › Cellulase II
- › Protease III
- › Protease IV
- › Lipase I
- › Lipase II
- › Lactase I
- › Lactase II
Other (inactive) ingredients: Hypromellose, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
CompleteGest by Nature's Way Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in CompleteGest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for CompleteGest, from the product label.
Nature's Way
See all Nature's Way products- Name
- Nature's Way Brands, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 1-800-962-8873
- Web Address
- naturesway.com
CompleteGest by Nature's Way: Common Questions
Does CompleteGest by Nature's Way interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product actually help digestion?
Is it safe to take if I'm pregnant?
Can I take this while breastfeeding?
Are there any side effects?
What does each enzyme in this product do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CompleteGest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CompleteGest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Phytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
CompleteGest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC