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Dietary supplement

Primadophilus Kids Orange Flavored Ingredients & Drug Interactions

by Nature's Way

Primadophilus Kids Orange Flavored label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Primadophilus Kids Orange Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Primadophilus Kids Orange Flavored is a dietary supplement by Nature's Way with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (La-14). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Primadophilus Kids Orange Flavored by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Primadophilus Kids Orange Flavored by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Primadophilus Kids Orange Flavored by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (28 mg) without saying how much of each component you get.

Primadophilus Kids Orange Flavored is a three-ingredient probiotic blend designed for children. The active ingredients are Lactobacillus acidophilus (La-14), Lactobacillus plantarum (LP-115), and Bifidobacterium bifidum/lactis (Bb-02)—all live, beneficial bacteria meant to support digestive health.

The tablet also contains several inactive ingredients for flavor, texture, and stability, including xylitol, inulin, and magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy digestive flora.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance, and more.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis. It's rated possibly ineffective for atopic disease (allergic conditions), and there isn't enough reliable evidence yet to rate it for acute respiratory distress syndrome.

The effectiveness ratings for the other two strains in this product are not on file in our data.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy children and adults. The product may rarely cause mild gastrointestinal side effects such as bloating, gas, or abdominal discomfort when taken with other probiotics, though these events are uncommon.

Because probiotics contain live organisms, there's a theoretical concern about infection in certain high-risk patients, though this is rare. The safety data for the other two probiotic strains are limited, and pregnancy safety for Lactobacillus acidophilus is rated possibly safe, though lactation data aren't on file.

Talk with your pediatrician before use, especially if your child has a weakened immune system or serious illness.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If your child is taking antibiotic drugs, space out the timing with this probiotic—they can interfere with each other. That's the only interaction we have data for in this product.

Use the medication checker below to confirm your child's specific drugs aren't affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Primadophilus Kids Orange Flavored is a three-strain probiotic that may help with digestive issues like antibiotic-associated diarrhea and IBS. The main thing to watch is timing with antibiotics—they can interfere with each other, so spacing them out matters.

If your child is on any prescription medication, especially antibiotics, check with your pediatrician or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Primadophilus Kids Orange Flavored, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674142424
Net contents 30 Chewable Tablet(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 267923
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Gluten Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Primadophilus Kids Orange Flavored by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
30
UPC/BARCODE
033674142424
IngredientAmount% DV
Proprietary Probiotic Blend28 mg--
Lactobacillus acidophilus (La-14)0 NP--
Lactobacillus plantarum LP-1150 NP--
Bifidobacterium bifidum/lactis (Bb-02)0 NP--

Other ingredients: Xylitol, Inulin, Hydroxypropyl Cellulose, Stearic Acid, Natural Flavors, Citric Acid, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Once daily

Children 2 years of age and older, chew 1 tablet daily. Instruct child to chew tablet thoroughly before swallowing.

Formulation

Supports healthy digestive flora

True Identity

True potency 3 Billion CFU

Exclusively backed by True Guarantee True Potency ensures 3 billion CFUs per chewable for the entire shelf life True Identity ensures only the strains listed on the label are found in the product True Guarantee probiotic Formulated with 3 probiotic strains to support healthy digestive flora Delicious orange flavor

Gluten-free

Innovative bottle technology improves shelf life! New dual-layer bottle technology helps maintain potency through shelf life. The innovative inner layer removes moisture while the outer wall helps prevent moisture from reaching the probiotics. Other probiotic bottles don't absorb moisture, which could potentially compromise quality and potency. CSP Technologies

Formula

Lactobacilli & Bifidobacteria

Ages 2+

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Recommendation: Not for children under 2 years of age due to choking hazard.

Caution: If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Not for use in premature infants. Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Storage

Keep refrigerated to maintain maximum potency.

Keep refrigerated to maintain maximum potency.

Seals/Symbols

Certified Authentic Tru-ID

Quality Global Sourcing Bottled & tested in the USA

Brand IP Statement(s)

2021 Distributed by Nature's Way Brands, LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Primadophilus Kids Orange Flavored by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Primadophilus Kids Orange Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Primadophilus Kids Orange Flavored by Nature's Way

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

28 mg per serving

Other (inactive) ingredients: Xylitol, Inulin, Hydroxypropyl Cellulose, Stearic Acid, Natural Flavors, Citric Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Primadophilus Kids Orange Flavored by Nature's Way Drug Interactions

Want to check YOUR meds against Primadophilus Kids Orange Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus (La-14) 182

Individual Drug Interactions

The ingredients in Primadophilus Kids Orange Flavored interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Primadophilus Kids Orange Flavored interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus (La-14)

Each ingredient & the kinds of drugs it affects

For each ingredient in Primadophilus Kids Orange Flavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (La-14)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (La-14) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Primadophilus Kids Orange Flavored, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Primadophilus Kids Orange Flavored by Nature's Way: Common Questions

Does Primadophilus Kids Orange Flavored by Nature's Way interact with any medications?
Yes. Based on its ingredients, Primadophilus Kids Orange Flavored has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Primadophilus Kids Orange Flavored contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child if she's on antibiotics?
Not at the same time. The live bacteria in this probiotic can be killed by antibiotics, so you'll want to separate when you give them. Your pediatrician or pharmacist can tell you the right timing—often it's a few hours apart.
What are the active ingredients in Primadophilus Kids?
There are three live probiotic strains: Lactobacillus acidophilus (La-14), Lactobacillus plantarum (LP-115), and Bifidobacterium bifidum/lactis (Bb-02). Each one is a type of beneficial bacteria.
Does this product have fillers or other inactive stuff?
Yes, it has several inactive ingredients for flavor and texture, including xylitol for sweetness, inulin for fiber, and magnesium stearate as a binder. The natural orange flavor comes from natural flavoring.
Is it safe for kids with a compromised immune system?
That's a question for your pediatrician. Although Lactobacillus acidophilus is generally well tolerated, taking live probiotics carries a small theoretical risk in children with weakened immune systems, so personalized medical advice is important.
Can this help with diarrhea after antibiotics?
Lactobacillus acidophilus is rated possibly effective for antibiotic-associated diarrhea, meaning the evidence supports it may help. But timing matters—space out the probiotic and antibiotic doses so the antibiotic doesn't kill off the live bacteria.
What side effects might happen?
Most children tolerate it well. Rarely, mild gastrointestinal symptoms like gas, bloating, or stomach discomfort can occur, especially if combined with other probiotics. If your child has unusual symptoms, talk with your pediatrician.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Primadophilus Kids Orange Flavored label
Go deeper

The Full Monographs Behind Primadophilus Kids Orange Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Primadophilus Kids Orange Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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