No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Cotton Ingredients & Drug Interactions

by Herb Pharm

Cotton label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cotton against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Cotton is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for menstrual cramps and bringing on menses, cooking oil (cottonseed oil), traditional use as a contraceptive (gossypol).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Cotton by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: cotton root bark (Gossypium hirsutum) extract, a traditional herbal preparation. The extract is suspended in certified organic cane alcohol and certified organic vegetable glycerin as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cotton product and its label doesn't state a use — see Cotton's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for cotton root bark is insufficient to rate its effectiveness for malaria. If you're considering this product for any condition, your best bet is to talk with your doctor or pharmacist about what the research actually shows for your situation.

The evidence, ingredient by ingredient Cotton

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cotton root bark contains gossypol, a compound that can be toxic at higher amounts, and medicinal use of this plant hasn't been well studied. The safety data advises against use during pregnancy — it's traditionally been used to stimulate the uterus and end pregnancy.

The data also advises against use while breastfeeding, since gossypol may pass to your infant and safety is unknown. If you're pregnant, planning pregnancy, or breastfeeding, skip this product and talk with your doctor about what's safe for you.

Side effects, ingredient by ingredient Cotton

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for the ingredients we could check. That said, run your exact medications through the search tool on this page just to be sure.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.

Cotton root bark has a long traditional history but very little modern research backing it. If you're pregnant or breastfeeding, avoid it — the data says it's not safe.

Anyone else should discuss it with their pharmacist, especially if they take other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cotton, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700001407
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220557
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cotton by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
168
UPC/BARCODE
090700001407
IngredientAmount% DV
Cotton root bark (Gossypium hirsutum) extract672 mg--

Other ingredients: certified organic Cane Alcohol, certified organic Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 4 times per day. Best taken between meals.

Precautions

Caution: Seek expert medical advice before taking during pregnancy.

Keep out of the reach of children

Storage

Store away from heat & light

Formula

Gossypium hirsutum

Cotton liquid extract

We prepare our Cotton Extract from the fresh (undried) root bark of certified organically grown Gossypium hirsutum plants.

Formulation

Optimal well-being

Gluten-free

Fresh herb / menstruum ratio: 1 1.5

Certified organic by Organic Certifiers

Seals/Symbols

USDA Organic

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cotton by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cotton label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cotton by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container168 Amounts shown are per serving.

Cotton root bark (Gossypium hirsutum) extract

No known
interactions
672 mg per serving

Cotton is best known as a fiber and food-oil crop, but its root bark and seed have a long history in folk medicine for menstrual and reproductive comp...

Cotton root bark (Gossypium hirsutum) extract monograph & interactions

Other (inactive) ingredients: Certified organic Cane Alcohol, Certified organic Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cotton by Herb Pharm Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Cotton. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Cotton, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Cotton by Herb Pharm: Common Questions

Does Cotton by Herb Pharm interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Cotton. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Cotton contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy because cotton root bark has traditionally been used to stimulate the uterus and end pregnancy. While breastfeeding, it's also not recommended — gossypol (a compound in cotton) may pass to your infant and safety is unknown. Talk with your doctor about what's safe for you.
Is cotton root bark safe at any dose?
Cotton root bark contains gossypol, which can be toxic at higher amounts. Medicinal use of this plant hasn't been well studied, so we don't have solid data on safe dosing. That's why it's a good idea to check with your pharmacist before starting it.
What is this product supposed to do?
The evidence we hold rates it as having insufficient reliable evidence for malaria. We don't have effectiveness data for other uses. Your pharmacist can tell you what research exists for whatever condition you're thinking about treating.
Does this interact with my medications?
No interactions are documented in our data for cotton root bark. That doesn't guarantee none exist — it just means this ingredient hasn't been checked against drugs in our system. Use the search tool on this page to look up your exact medications, or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cotton is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cotton label
Go deeper

The Full Monographs Behind Cotton’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cotton

Cotton is best known as a fiber and food-oil crop, but its root bark and seed have a long history in folk medicine for menstrual and reproductive complaints. Its seed pigment, gossypol, was...

Read the full Cotton monograph →
Sources

Sources & How We Checked

Cotton's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cotton 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Ankrah, N. A., Nyarko, A. K., Addo, P. G., Ofosuhene, M., Dzokoto, C., Marley, E., Addae, M. M., and Ekuban, F. A. Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria. Phytother.Res 2003;17(6):697-701. PubMed

See these in context on the Cotton monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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