D-Mannose 2 g Unflavored Ingredients & Drug Interactions
by Nutricost
What is this page for?
First and foremost: checking D-Mannose 2 g Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 2 g Unflavored is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 2 g Unflavored by Nutricost
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a simple sugar that your body doesn't fully metabolize the way it does glucose. It's a 2 gram powder with no inactive fillers or other ingredients listed.
Does it work?
Strong evidence
The evidence for D-mannose is mixed. It's considered likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic disorder.
For urinary tract infections — the reason many people reach for it — the data rates it as possibly ineffective, meaning the evidence doesn't support its use for that purpose. If you're thinking about using it for UTI prevention or treatment, talk with your doctor first about whether it makes sense for you.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but long-term safety data are limited. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea has been reported in adults taking 2 grams daily over 6 months, and larger single doses (more than 200 mg per kilogram of body weight) are more likely to trigger osmotic diarrhea — essentially, the sugar pulls water into your intestines. Safety during pregnancy isn't well studied, so the data advise against use unless your doctor recommends it.
The same caution applies to breastfeeding.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Still, run your exact medications through the checker below, and let your pharmacist know you're taking this.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is generally well tolerated short-term and has no documented drug interactions. If you're using it for a rare genetic condition and your doctor has recommended it, this product is straightforward.
If you're considering it for UTIs, the evidence doesn't support that use — talk with your pharmacist or doctor about other options. Watch for digestive upset, especially diarrhea.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 2 g Unflavored, straight from the product label.
| Brand | Nutricost |
|---|---|
| Barcode (UPC) | 702669937313 |
| Net contents | 8.8 Ounce(s); 250 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2024 |
| DSLD ID | 307785 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 2 g Unflavored by Nutricost, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| D-Mannose | 2 Gram(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Recommended use: As a dietary supplement, mix 1 scoop daily with 6-10 oz of water or as directed by your healthcare professional.
Formulation
Third party tested
Non-GMO Gluten-free
Made and quality tested in the USA with globally sourced ingredients.
Non-GMO Product
Precautions
Warning: For healthy individuals 18 years and older.
Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Do not use if safety seal is broken or missing.
Storage
Notice: Store in a cool, dry place.
General Statements
Contents are sold by weight, not volume. Some settling may occur.
Formula
D-Mannose 2 g per serving 250 g per container
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Nutricost quality guaranteed Third party tested GMP compliant facility
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 2 g Unflavored by Nutricost label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 2 g Unflavored by Nutricost
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Gram(s) Dosage formPowder Servings per container125 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsD-Mannose 2 g Unflavored by Nutricost Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 2 g Unflavored. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 2 g Unflavored, from the product label.
Nutricost
See all Nutricost products- Name
- Nutricost
- Street Address
- 351 E 1750 N
- City
- Vineyard
- State
- UT
- ZipCode
- 84059
- Phone Number
- (866) 438-3694
- Web Address
- www.nutricost.com
D-Mannose 2 g Unflavored by Nutricost: Common Questions
Does D-Mannose 2 g Unflavored by Nutricost interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help prevent or treat a urinary tract infection?
What side effects might I have?
Is it safe to take while pregnant?
Can I take it while breastfeeding?
How long is it safe to take?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 2 g Unflavored is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 2 g Unflavored’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 2 g Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC