D-Mannose 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 500 mg is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 500 mg by Protocol For Life Balance
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a naturally occurring simple sugar. D-mannose is thought to work by helping prevent certain bacteria from sticking to the urinary tract wall.
The capsule itself is made of hypromellose (a plant-based material), with rice flour, stearic acid, magnesium stearate, and silicon dioxide as inactive ingredients to help hold the capsule together and aid manufacturing.
Does it work?
Leans against
The evidence for D-mannose is mixed. For carbohydrate-deficient glycoprotein syndrome type 1b — a rare genetic condition — it is likely effective.
For urinary tract infections (UTIs), however, the evidence suggests it is possibly ineffective, meaning current data do not support its use for that purpose despite its popularity.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but long-term safety data of high quality are limited, so we don't know what happens with extended use. The most common side effects are bloating, diarrhea, and nausea — and higher single doses (over 200 mg/kg) are more likely to trigger osmotic diarrhea.
There isn't enough reliable safety data during pregnancy, so it's best to avoid it unless your doctor advises otherwise. Safety while breastfeeding is also not well studied, so caution is advised if you're nursing.
Meds to double-check
No known interactions
No interactions are documented for D-mannose in our data. That doesn't mean none exist, so if you're on any regular medications, a quick conversation with your doctor or pharmacist is still a smart move before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose may be worth considering if you have carbohydrate-deficient glycoprotein syndrome type 1b under medical guidance, but the evidence doesn't support using it for UTIs. Side effects like bloating and diarrhea are mild and common.
Talk with your doctor or pharmacist about whether this fits your situation, especially if you're pregnant, breastfeeding, or planning long-term use.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 500 mg, straight from the product label.
| Brand | Protocol For Life Balance |
|---|---|
| Barcode (UPC) | 707359128118 |
| Net contents | 90 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 22, 2023 |
| DSLD ID | 292259 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 500 mg by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Total Sugars | 2 Gram(s) | -- |
| D-Mannose | 2 Gram(s) | -- |
Other ingredients: Hypromellose, Rice Flour, Stearic Acid, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested usage: Take 4 capsules 1 to 2 times daily or as directed by your healthcare practitioner.
Formula
How it works: D-Mannose is a simple sugar that is taken up in the GI tract and rapidly excreted in the urine without affecting blood sugar regulation. D-Mannose helps to support a normal environment within the bladder by maintaining a healthy mucosal lining and promoting proper elimination. Clinical studied indicate that D-Mannose can help to maintain normal urinary tract health when used regularly.
Precautions
Cautions/interactions: There are no known drug interactions.
Produced in a GMP facility that processes other ingredients containing these allergens.
May cause mild, but transient GI discomfort.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Natural color variation may occur in this product.
Cleanses the bladder Supports a healthy urinary tract
Non-GMO
Vegetarian/vegan
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
FDA Statement of Identity
A Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 500 mg by Protocol For Life Balance label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 500 mg by Protocol For Life Balance
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size4 Capsule(s) Dosage formCapsule Servings per container22 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Hypromellose, Rice Flour, Stearic Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
D-Mannose 500 mg by Protocol For Life Balance Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 500 mg, from the product label.
Protocol For Life Balance
See all Protocol For Life Balance products- Name
- Protocol For Life Balance
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- www.protocolforlife.com
D-Mannose 500 mg by Protocol For Life Balance: Common Questions
Does D-Mannose 500 mg by Protocol For Life Balance interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help prevent or treat a urinary tract infection?
What are the most common side effects?
Is it safe to take D-mannose long-term?
Can I take this while pregnant or breastfeeding?
What is D-mannose and how does it work?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC