D-Mannose 500 mg Ingredients & Drug Interactions
by Source Naturals
What is this page for?
First and foremost: checking D-Mannose 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 500 mg is a dietary supplement by Source Naturals with 2 active ingredients. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 500 mg by Source Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a simple sugar (carbohydrate) your body doesn't fully use or store the way it does glucose. The capsule also holds inactive ingredients — gelatin, dibasic calcium phosphate, silica, magnesium stearate, and maltodextrin — which are fillers and binders that help form and preserve the capsule.
Does it work?
Leans against
D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic disorder where the body can't make certain proteins properly. For urinary tract infections (UTIs), the evidence rates as possibly ineffective — meaning the data we hold doesn't support it as a reliable treatment for that use.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but long-term safety data are limited. The most common side effects are bloating, diarrhea, and nausea.
At higher doses, especially single doses above 200 mg per kilogram of body weight, osmotic diarrhea (loose stools from the sugar drawing water into the intestine) is more likely. There isn't enough reliable safety data during pregnancy to know either way, so talk with your doctor or pharmacist before taking it if you're pregnant.
Safety while breastfeeding hasn't been well studied; caution is advised, and it's best to discuss this with your healthcare provider.
Meds to double-check
No known interactions
No interactions are documented in our data for D-mannose. That said, run your actual medications through the search tool on this page or confirm with your pharmacist before taking it — absence of documented data isn't a guarantee no interactions exist.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is likely effective for a specific genetic disorder (carbohydrate-deficient glycoprotein syndrome type 1b), but not supported for UTIs. It's generally well tolerated short-term, though bloating and diarrhea can happen, especially at higher doses.
If you're pregnant, breastfeeding, or on any medications, talk with your doctor or pharmacist before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 500 mg, straight from the product label.
| Brand | Source Naturals |
|---|---|
| Barcode (UPC) | 021078021971 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2020 |
| DSLD ID | 213801 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 500 mg by Source Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Sugar | 1 Gram(s) | -- |
| D-Mannose | 500 mg | -- |
Other ingredients: Gelatin, Dibasic Calcium Phosphate, Silica, Magnesium Stearate, Maltodextrin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Formulation
Supports urinary tract health
Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no preservatives, or artificial color, flavor or fragrance.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 capsule twice daily.
Precautions
Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
Storage
Store in a cool, dry place.
Formula
Imbalances of the urinary tract are widespread, and it is estimated that 20 percent of women will experience them. Source Naturals D-Mannose supports the health of the entire urinary tract: the uretha, bladder, ureter, renal pelvis and the renal parenchyma. D-Mannose is a monosaccharide hexose sugar, naturally found in some trees, berries and fruits, such as cranberry. It complements the body's natural cleansing process.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 500 mg by Source Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 500 mg by Source Naturals
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Gelatin, Dibasic Calcium Phosphate, Silica, Magnesium Stearate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.
D-Mannose 500 mg by Source Naturals Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 500 mg, from the product label.
Source Naturals
- Name
- Source Naturals, Inc.
- Street Address
- P. O. Box 2118
- City
- Santa Cruz
- State
- CA
- ZipCode
- 95062
- Web Address
- www.sourcenaturals.com
D-Mannose 500 mg by Source Naturals: Common Questions
Does D-Mannose 500 mg by Source Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is D-mannose and what does it do?
What side effects should I expect?
Is it safe to take during pregnancy?
Is it safe while breastfeeding?
Can I take D-mannose long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC