No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

D-Mannose Ingredients & Drug Interactions

by BulkSupplements.com

D-Mannose label
See full label image
Powder Category: Other Combinations
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Mannose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

D-Mannose is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of D-Mannose by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: D-mannose, a naturally occurring sugar. D-mannose is used orally to support urinary tract health and to treat certain genetic metabolic conditions.

The product comes as a powder with no other inactive ingredients listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded D-mannose's overall clinical evidence instead.

Strong

Strong clinical evidence supports D-mannose for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Carbohydrate-deficient glycoprotein syndrome type 1b — rated "Likely Effective" (Natural Medicines).

D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic metabolic disorder. For urinary tract infections (UTIs), the evidence suggests it is possibly ineffective — meaning current studies do not show it works for that purpose.

If you're considering it for a urinary tract concern, talk with your doctor or pharmacist about what the evidence actually supports.

The evidence, ingredient by ingredient D-mannose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-mannose is generally well tolerated short-term, but high-quality long-term safety data are limited. The most common side effects are bloating, diarrhea, and nausea.

Diarrhea and loose stools are more likely when you take a single dose greater than 200 mg/kg, which causes osmotic diarrhea — the sugar pulls water into your gut. During pregnancy, there isn't enough reliable safety data, so it's best to avoid it unless your doctor advises otherwise.

Safety while breastfeeding is not well studied, so caution is advised — talk with your doctor or pharmacist before use if you are pregnant or breastfeeding.

Side effects, ingredient by ingredient D-mannose

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for D-mannose. However, because long-term safety data are limited, talk with your doctor or pharmacist before adding this to your routine, especially if you take medications regularly.

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

D-mannose is likely effective for a specific rare genetic condition (carbohydrate-deficient glycoprotein syndrome type 1b) but not shown to work for urinary tract infections. It's generally well tolerated short-term, though digestive side effects like bloating and diarrhea are possible.

If you're pregnant, breastfeeding, or taking prescription medications, check with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Mannose, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000OJFAQR
Net contents 500 Gram(s); 17.6 Oz(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 253715
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Mannose by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2000 Milligram(s)
Maximum serving Sizes:
2000 Milligram(s)
Servings per container
250
UPC/BARCODE
X000OJFAQR
IngredientAmount% DV
D-Mannose2000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & Pure Bulk Supplements

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2000 mg (about 3/4 tsp) once daily, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Mannose by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Mannose label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Mannose by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2000 Milligram(s) Dosage formPowder Servings per container250 Amounts shown are per serving.

D-Mannose

No known
interactions
2000 mg per serving

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...

D-Mannose monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Mannose by BulkSupplements.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for D-Mannose, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

D-Mannose by BulkSupplements.com: Common Questions

Does D-Mannose by BulkSupplements.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in D-Mannose. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
D-Mannose contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does D-mannose actually help with urinary tract infections?
The evidence suggests it is possibly ineffective for UTIs — meaning current studies don't show it works for that purpose. If you're dealing with a urinary tract concern, talk with your doctor or pharmacist about treatments that do have evidence behind them.
What are the side effects?
The most common ones are bloating, diarrhea, and nausea. Diarrhea is more likely if you take a single dose greater than 200 mg/kg, which can cause osmotic diarrhea — the sugar pulls water into your gut. Starting with a smaller dose may help.
Is it safe to take long-term?
D-mannose is generally well tolerated short-term, but high-quality long-term safety data are limited. If you're thinking about taking it regularly, talk with your doctor or pharmacist about what's known and what isn't.
Can I take it while pregnant?
There isn't enough reliable safety data during pregnancy, so it's best to avoid it unless your doctor advises otherwise. Talk with your doctor or pharmacist before use if you're pregnant.
Is it safe while breastfeeding?
Safety while breastfeeding is not well studied, so caution is advised. Talk with your doctor or pharmacist before taking it if you're breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Mannose is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Mannose label
Go deeper

The Full Monographs Behind D-Mannose’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

D-mannose

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...

Read the full D-mannose monograph →
Sources

Sources & How We Checked

D-Mannose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

D-mannose 6 references
  1. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
  2. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
  3. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
  4. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
  5. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
  6. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed

See these in context on the D-mannose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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