D-Mannose Ingredients & Drug Interactions
by SuperiorLabs
What is this page for?
First and foremost: checking D-Mannose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose is a dietary supplement by SuperiorLabs with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose by SuperiorLabs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a type of simple sugar. D-mannose is the only ingredient that does the work here.
The capsule also contains cellulose and rice concentrate as inactive ingredients (fillers and binders).
Does it work?
Strong evidence
The evidence for D-mannose is mixed. It's likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic condition.
For urinary tract infections (UTIs), though, the evidence suggests it's possibly ineffective — meaning we don't have solid proof it works for that purpose, despite its popularity for bladder health.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but long-term safety data are limited, so we don't have a full picture of what happens if you take it for months or years. The most common side effects are bloating, diarrhea, and nausea.
Loose stools and abdominal bloating appear more likely at higher doses — especially doses above 200 mg per kilogram of body weight in a single sitting, which can trigger osmotic diarrhea (watery stools from sugar drawing water into your bowels). Safety during pregnancy is not well studied, so the data advise against use unless your doctor advises otherwise.
Breastfeeding safety is also not well studied, so caution is advised.
Meds to double-check
No known interactions
No interactions are documented for D-mannose with any medications we could check. That said, it's always smart to confirm with your pharmacist if you're taking anything new or unusual.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
If you have carbohydrate-deficient glycoprotein syndrome type 1b, D-mannose may be worth discussing with your doctor — the evidence supports its use. For UTIs, the data don't support its effectiveness.
Anyone considering long-term use should talk with their pharmacist or doctor, since we don't have solid long-term safety data. Pregnant or breastfeeding?
Check with your healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose, straight from the product label.
| Brand | SuperiorLabs |
|---|---|
| Barcode (UPC) | 850569006254 |
| Net contents | 120 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 338177 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose by SuperiorLabs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| D-Mannose | 500 mg | -- |
Other ingredients: Cellulose, Rice Concentrate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
D-Mannose is a monosaccharide hexose sugar that is part of the family of sugars in the aldohexose series. It is a sugar made by plants and is primarily found in cranberries, apples, peaches, and raspberries, among other plants. D-Mannose can help maintain a healthy urinary tract. It is also considered to be a supporter of liver and intestinal function. Superior Labs D-Mannose capsules contain 500mg pure D-Mannose, with absolutely no magnesium stearate, dioxides, preservatives, or other potentially harmful artificial ingredients of any kind.
Pure D-Mannose
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, adults take 1 capsule two to three times per day or as directed by your health care practitioner. Best when taken with a meal.
Precautions
Caution: Do not exceed recommended dosage.
Please consult a physician before consuming this product if you are pregnant or nursing, taking medication or have a medical condition.
Not intended for use by individuals under the age of 18. Keep out of reach of children.
Do not use if safety seal is damaged or missing.
Storage
Store in a cool, dry place.
Seals/Symbols
Metal Safe Heavy Metal Tested GMP Compliant Facility Manufactured in the USA with globally sourced ingredients
Formulation
Metal Safe Heavy Metal Tested
Optimal absorption Pure and potent Urinary tract health Supports healthy liver function Supports healthy intestine This product is formulated, developed and manufactured in a Food and Drug Administration registered and GMP compliant facility, 3rd party inspected by a leading compliance authority for superior quality assurance.
Does not contain: Magnesium stearate, dioxides, preservatives, or artificial ingredients of any kind.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose by SuperiorLabs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose by SuperiorLabs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Cellulose, Rice Concentrate. These complete the product’s ingredient list but are not active constituents.
D-Mannose by SuperiorLabs Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose, from the product label.
SuperiorLabs
See all SuperiorLabs products- Name
- Superior Labs, LLC.
- City
- Park City
- State
- UT
- ZipCode
- 84098
- Phone Number
- (888) 708-5227
- Web Address
- www.superiorlabs.com
D-Mannose by SuperiorLabs: Common Questions
Does D-Mannose by SuperiorLabs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help my UTI?
What side effects should I expect?
Is it safe to take long-term?
Can I take this while breastfeeding?
Is D-mannose a real ingredient or just marketing?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC