D-Mannose Pure Powder Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking D-Mannose Pure Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose Pure Powder is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose Pure Powder by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a simple sugar your body uses naturally. The powder form means there are no inactive fillers or binders — just the D-mannose itself.
Does it work?
Leans against
The evidence for D-mannose is mixed. It's rated likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare metabolic condition.
For urinary tract infections (UTIs), however, the evidence suggests it's possibly ineffective — meaning the data doesn't support its use for that purpose, even though it's often marketed that way.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but high-quality long-term safety data are limited — we simply don't have enough long-term study to know if it's safe over years. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea is more likely at higher doses (above 200 mg per kilogram of body weight). There isn't enough reliable safety data in pregnancy, so it's best to avoid it unless your doctor advises otherwise.
Safety while breastfeeding is not well studied, so caution is advised if you're nursing.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, always run your specific medications through the checker on this page before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose may help with a rare metabolic condition, but the evidence doesn't support using it for UTIs. It's generally tolerated short-term, though digestive side effects like diarrhea and bloating can happen.
Talk to your pharmacist if you're pregnant, breastfeeding, or taking it long-term.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose Pure Powder, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739028105 |
| Net contents | 3 Ounce(s); 85 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 314272 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose Pure Powder by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Total Sugars | 2 Gram(s) | -- |
| D-Mannose | 2 Gram(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 level teaspoon 1 to 2 times daily. Take with water or unsweetened juice, such as unsweetened cranberry juice.
Formula
D-Mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. It's metabolized only in small amounts, with excess amounts rapidly excreted in urine, so it won't interfere with healthy blood sugar regulation. Clinical studies have demonstrated that, when taken regularly, D-Mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining.
Triangle K (Kosher)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Do not eat freshness packet enclosed. Keep in bottle.
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Storage
Keep bottle tightly closed at all times in between usage.
Store in a cool, dry place after opening.
This product is sold by weight not volume.
Formulation
Natural color variation may occur in this product.
Healthy urinary tract Cleanses the bladder
Certified Organic USDA Organic
Non-GMO
Vegetarian/Vegan
Certified Organic QAI.
Packaged and quality tested in the USA.
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
Seals/Symbols
USDA Organic
Triangle K (Kosher)
GMP Quality Assured
FDA Statement of Identity
A Dietary Supplement
General Statements
General Health Family owned since 1968.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose Pure Powder by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose Pure Powder by NOW
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Level Teaspoon(s) Dosage formPowder Servings per container43 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsD-Mannose Pure Powder by NOW Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose Pure Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose Pure Powder, from the product label.
NOW
See all NOW products- Name
- NOW FOODS
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
D-Mannose Pure Powder by NOW: Common Questions
Does D-Mannose Pure Powder by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help prevent or treat UTIs?
What are the most common side effects?
Can I take it while pregnant?
Is this safe to take long-term?
Is this just a filler or does it have an actual role?
Can I take this while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose Pure Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose Pure Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose Pure Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC