D-Mannose with Hibiscus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose with Hibiscus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose with Hibiscus is a dietary supplement by Signature Supplements with 2 active ingredients. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose with Hibiscus by Signature Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: D-Mannose, a simple sugar that your body doesn't break down the way it does glucose, and Hibiscus, a flower extract. The capsules also hold inactive ingredients (cellulose and diatomaceous earth) that give them their form.
D-Mannose is the main player here — it's used as a dietary supplement, though what it actually does in your body depends on which condition you're thinking about.
Does it work?
Leans against
The evidence for D-Mannose is mixed. For carbohydrate-deficient glycoprotein syndrome type 1b (a rare genetic condition), it's likely effective.
For urinary tract infections (UTIs), though — which is what many people reach for D-Mannose hoping to prevent or treat — the data shows it's possibly ineffective. We hold no effectiveness information for Hibiscus in our data.
How safe is it?
Well-documented data
D-Mannose is generally well tolerated over the short term, though long-term safety data are limited. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea shows up more often at higher doses — especially above 200 mg per kilogram of body weight — but loose stools and bloating have been reported even at lower doses. The safety data for pregnancy are not adequate, so it's best to avoid it unless your doctor advises otherwise.
Safety while breastfeeding hasn't been well studied, so caution is advised if you're nursing.
Meds to double-check
No known interactions
No interactions are documented for the ingredients we could check in this product. Run your exact medications through the tool on this page to be certain, or ask your pharmacist before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-Mannose with Hibiscus is a low-interaction choice, but its real-world usefulness depends on why you're taking it. If you're hoping it'll help with UTIs, the evidence suggests it won't.
If you have a genetic condition your doctor's already flagged, that's a different story — talk with them. Either way, chat with your pharmacist if you're pregnant, breastfeeding, or prone to loose stools.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose with Hibiscus, straight from the product label.
| Brand | Signature Supplements |
|---|---|
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 338988 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose with Hibiscus by Signature Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| D-Mannose | 700 mg | -- |
| Hibiscus | 150 mg | -- |
Other ingredients: Cellulose, Diatomaceous Earth
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
No: chemical fillers or binders, artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
From a GMP Facility
Fast acting UTI Support
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Formula
D-Mannose and Hibiscus works to support short and long term urinary tract health.
Suggested/Recommended/Usage/Directions
Directions: For adults, take two (2) capsules daily, more if needed
Precautions
Not intended for use by persons under the age of 18..
As a reminder, discuss the supplements and medications you take with your health care providers. Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose with Hibiscus by Signature Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose with Hibiscus by Signature Supplements
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsHibiscus
Other (inactive) ingredients: Cellulose, Diatomaceous Earth. These complete the product’s ingredient list but are not active constituents.
D-Mannose with Hibiscus by Signature Supplements Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose with Hibiscus. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose with Hibiscus, from the product label.
Signature Supplements
See all Signature Supplements products- Name
- Signature Supplements
- Street Address
- P.O. Box 1112
- City
- San Clemente
- State
- CA
- Web Address
- yoursignaturesupplements.com
D-Mannose with Hibiscus by Signature Supplements: Common Questions
Does D-Mannose with Hibiscus by Signature Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-Mannose help prevent or treat a urinary tract infection?
What are the most common side effects?
Can I take this if I'm pregnant or breastfeeding?
How long is it safe to take D-Mannose?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose with Hibiscus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose with Hibiscus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose with Hibiscus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC