Digest Ingredients & Drug Interactions
by Enzymedica
What is this page for?
First and foremost: checking Digest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digest is a dietary supplement by Enzymedica with 12 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Digest by Enzymedica
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Enzymedica Digest contains 12 active digestive enzymes: amylase, protease, lipase, lactase, cellulase, invertase, glucoamylase, alpha-galactosidase, xylanase, pectinase, maltase, and hemicellulase. These are meant to break down different components of food — carbohydrates, proteins, fats, fiber, and complex sugars — to support digestion.
The formula also includes cellulose and water as inactive ingredients.
Does it work?
Strong evidence
The evidence isn't established in our data for most of these enzymes. Lactase is rated effective for lactose intolerance — if you have trouble digesting dairy, this ingredient may help.
For the others — protease, lipase, and the remaining enzymes — we don't hold reliable effectiveness data for digestive complaints like general dyspepsia or inflammatory bowel disease.
How safe is it?
Well-documented data
Protease, lipase, and lactase are generally well tolerated for most adults, though they can occasionally cause digestive upset or allergic reactions. Rare cases of allergic reactions to these enzymes have been reported, including contact dermatitis and allergic rhinitis.
If you have a serious digestive condition, use only under medical guidance. During pregnancy, the safety data is limited — talk to your doctor before taking this product regularly.
The same goes for breastfeeding; there isn't enough safety information, so check with your healthcare provider first.
Meds to double-check
No known interactions
No interactions are documented in our data for the digestive enzymes we could check in this product.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Digest works best if you're looking to break down lactose or want general enzyme support for digestion. If you have a serious digestive condition or are pregnant or breastfeeding, check with your doctor first.
Let your pharmacist know you're taking it, especially if you're on any medications — though no interactions are currently documented.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digest, straight from the product label.
| Brand | Enzymedica |
|---|---|
| Barcode (UPC) | 670480981153 |
| Net contents | 240 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 328915 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digest by Enzymedica, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
Other ingredients: Cellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Enzymedica supports AHA Autism Hope Alliance Vitamin Angels Proud Supporters Green Mountain Energy
Complete #1 Selling enzyme brand
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Enzyme deficiencies may result from a combination of age, diet and lifestyle. These deficiencies can lead to a variety of digestive discomforts, including occasional gas, bloating, indigestion and irregularity. Digest is an advanced formula that breaks down carbohydrates, fats, fiber and protein. Digestive well-being improves concentration and increases vitality.
No fillers added
Made in USA with global ingredients
Non GMO
Digestive
Enhanced digestive support
Twice the enzyme power of Digest Basic
Vegan & Kosher
Contains No: Gluten, milk, casein, soy, egg, artificial colors or flavors.
Formula
The enzymes included in Digest support optimal digestion by helping the body absorb nutrients and convert food into energy.
Thera-blend enzymes are comprised of multiple variants which are blended to work synergistically throughout the broad pH range of the human body.
Complete enzyme formula
Vegan & Kosher
K Parve (Kosher) #K1840
Suggested/Recommended/Usage/Directions
Recommended Use: 1 capsule with each meal. More may be taken as needed. For higher enzyme potency, Enzymedica's Digest Gold may be helpful.
Brand IP Statement(s)
Enzymedica Natural Digestive Health & Wellness
FDA Statement of Identity
Dietary Supplement
Storage
Keep closed in dry place; avoid excessive heat.
Precautions
Do not use if safety seal is broken or missing.
Please keep out of reach of children.
Seals/Symbols
K Parve (Kosher) #K1840
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digest by Enzymedica label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digest by Enzymedica
These are the 12 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Amylase
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsLactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsCellulase
Invertase
Glucoamylase
Alpha-Galactosidase
Xylanase
Pectinase
Maltase
Hemicellulase
Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.
Digest by Enzymedica Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Digest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Digest, from the product label.
Enzymedica
See all Enzymedica products- Name
- Enzymedica, Inc.
- Street Address
- 771 Commerce Drive
- City
- Venice
- State
- FL
- ZipCode
- 34292
- Phone Number
- 1-888-918-1118
- Web Address
- enzymedica.com
Digest by Enzymedica: Common Questions
Does Digest by Enzymedica interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with lactose intolerance?
Is it safe to take while pregnant?
Can I take this while breastfeeding?
What are these enzymes supposed to do?
Can this cause allergic reactions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC