Digestive Enzyme Blend Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Digestive Enzyme Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestive Enzyme Blend is a dietary supplement by GNC Women's Ultra Mega with 5 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Digestive Enzyme Blend by GNC Women's Ultra Mega
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 5 active ingredients: three digestive enzymes called proteases (Protease 3, 4.5, and 6), lipase, and amylase. These are natural enzymes that your digestive system normally makes to break down food—proteases handle proteins, lipase breaks down fats, and amylase breaks down carbohydrates.
The product also contains inactive ingredients including maltodextrin, vegetable cellulose for the capsule, and medium chain triglycerides.
Does it work?
Not established
The evidence supporting these enzymes is limited. For lipase, the data we hold rates it insufficient to say whether it actually works for inflammatory bowel disease or indigestion.
The proteases in this product have no established effectiveness ratings in our database. That doesn't mean they don't work—just that the research backing them up isn't conclusive enough for us to rate them here.
How safe is it?
Well-documented data
Lipase and the proteases are generally well tolerated in adults, though some people report digestive upset or rarely allergic reactions to proteases. There's a caution for anyone with serious digestive conditions—use only under medical guidance.
Protease exposure in occupational settings has occasionally triggered allergic rhinitis or asthma, though that's rare. For pregnancy: safety data on lipase and proteases in pregnancy is limited, and lipase is best avoided unless your doctor advises it.
Breastfeeding safety hasn't been well studied either—check with your healthcare provider first if you're nursing. There's an additional caution about lipase in premature infants, which is a separate concern from general adult use.
Meds to double-check
No known interactions
No interactions are documented for the ingredients we could check in this product. Run your specific medications through the search tool on this page to confirm, or ask your doctor or pharmacist if you want a quick double-check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
This blend is generally well tolerated for most adults looking for digestive enzyme support, though the evidence for whether it actually works isn't strong. If you have serious digestive conditions or you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting.
Check your medications against the tool on this page to be certain, and feel free to bring your questions to your own healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestive Enzyme Blend, straight from the product label.
| Brand | GNC Women's Ultra Mega |
|---|---|
| Net contents | 30 Pack(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2017 |
| DSLD ID | 69692 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult Female (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestive Enzyme Blend by GNC Women's Ultra Mega, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Lipase | 0 NP | -- |
| Protease 4.5 | 0 NP | -- |
| Protease 3 | 0 NP | -- |
| Protease 6 | 0 NP | -- |
| Proprietary Enzyme Blend | 44.84 mg | -- |
Other ingredients: Maltodextrin, Vegetable Cellulose Capsule, Medium Chain Triglycerides
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Keep out of reach of children.
Discontinue use two weeks prior to surgery.
Storage
Store in a cool, dry place.
General Statements
Conforms to USP <2091> for weight. Meets USP <2040> disintegration.
Each pack contains: Digestive Enzyme Blend
Heart health Beauty Digestion
Achieve your daily nutritional goals with customized ingredients plus multivitamins that have more antioxidant power than ever, containing over 30 clinically studied ingredients - and are smaller and easier to swallow.
Digestion Helps you digest key nutrients for the energy you need.
Actual size
This product is endorsed by the GNC Medical Advisory Board. This team of esteemed physicians utilizes their expensive medical knowledge and experience to aid in the creation of GNC premium products, helping you to achieve optimal health through comprehensive nutritional support so you can live your best life!
New!
General
Code 208712 BQG
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take the contents of one pack daily with food.
Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Vitapak program with clinically studied multivitamin
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
No artificial colors, no artificial flavors, no wheat, gluten free, no dairy, yeast free.
Gf Gluten free
Seals/Symbols
Gf Gluten free
Physician Endorsed
Formula
Women's Ultra Mega Wellness Vitapak
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestive Enzyme Blend by GNC Women's Ultra Mega label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestive Enzyme Blend by GNC Women's Ultra Mega
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Enzyme Blend
- › Amylase
- › Lipase
- › Protease 4.5
- › Protease 3
- › Protease 6
Other (inactive) ingredients: Maltodextrin, Vegetable Cellulose Capsule, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.
Digestive Enzyme Blend by GNC Women's Ultra Mega Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Digestive Enzyme Blend. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Digestive Enzyme Blend, from the product label.
GNC Women's Ultra Mega
See all GNC Women's Ultra Mega products- Name
- General Nutrition Corporation
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15222
- Phone Number
- 1-888-462-2548
- Web Address
- gnc.com
Digestive Enzyme Blend by GNC Women's Ultra Mega: Common Questions
Does Digestive Enzyme Blend by GNC Women's Ultra Mega interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
What do these enzymes actually do?
Does this really help with indigestion or digestive problems?
Can these enzymes cause allergic reactions?
Does this product have fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestive Enzyme Blend is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestive Enzyme Blend’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph →Sources & How We Checked
Digestive Enzyme Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC