No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Digestive Enzyme Chewables Natural Mixed Berry Flavor Ingredients & Drug Interactions

by Pure Encapsulations

Tablet Or Pill Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Digestive Enzyme Chewables Natural Mixed Berry Flavor is a dietary supplement by Pure Encapsulations with 5 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Digestive Enzyme Chewables Natural Mixed Berry Flavor by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “DigeZyme Multienzyme Complex” is a proprietary blend — the label gives one combined amount (50 mg) without saying how much of each component you get.

This chewable contains five active digestive enzymes. Three of them—protease, lipase, and lactase—break down protein, fat, and milk sugar (lactose) respectively.

The other two, cellulase and alpha-amylase, work on plant fiber and starch. They're combined here as DigeZyme Multienzyme Complex.

The inactive ingredients are xylitol, mannitol, maltodextrin, cellulose, ascorbyl palmitate, and natural mixed berry flavor—these are fillers, sweeteners, binders, and flavoring.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support protein carbohydrate fiber and dairy digestion.
  • We looked for evidence on: Lactose intolerance, Dyspepsia, Gas and bloating, Indigestion, Lactase deficiency.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

Lactase in this product is effective for lactose intolerance. For the other enzymes—protease, lipase, cellulase, and alpha-amylase—the evidence in our data is insufficient to rate them for any condition.

Lipase and lactase have also been studied for inflammatory bowel disease (IBD) and other digestive conditions, but the data doesn't yet support claims about their effectiveness for those uses.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease, lipase, and lactase are generally well tolerated by most adults, though digestive upset is possible with any of them. Protease carries a rare risk of allergic reaction, including contact dermatitis or breathing problems in people exposed to powdered enzyme (occupational exposure is the main concern).

Lactase has caused allergic rhinitis (runny, itchy nose) in rare cases of powder exposure. For pregnancy: protease should be avoided unless your doctor prescribes it; lipase and lactase have limited safety data, so check with your doctor first.

For breastfeeding: protease and lipase are not recommended without medical advice; lactase is considered likely safe but ask your doctor or pharmacist to be sure.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Lactase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 3 matched ingredients has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. Because we hold no interaction data for cellulase and alpha-amylase, ask your pharmacist to review those two before combining this product with any medications you take.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This product may help if you have trouble digesting milk sugar (lactose intolerance), since lactase is effective for that. For general digestive support from the other enzymes, the evidence isn't established yet.

Because we couldn't check two of the five ingredients and you may have pregnancy, breastfeeding, or serious digestive concerns, talk it over with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzyme Chewables Natural Mixed Berry Flavor, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298024226
Net contents 100 Chewable Tablet(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 277667
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzyme Chewables Natural Mixed Berry Flavor by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
100
UPC/BARCODE
766298024226
IngredientAmount% DV
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Alpha-Amylase0 NP--
DigeZyme Multienzyme Complex50 mg--

Other ingredients: Xylitol, Mannitol, Maltodextrin, Cellulose, Ascorbyl Palmitate, Natural Mixed Berry Flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, adults and children ages 4 and up, chew 1 tablet with each meal, 1-3 times daily, or as directed by a health professional.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

Formula

Chewable enzyme blend to support protein, carbohydrate, fiber and dairy digestion

Formulation

Gluten-free & Non-GMO

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

DigeZyme is a registered trademark of Sabinsa Corporation.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Digestive Enzyme Chewables Natural Mixed Berry Flavor by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Digestive Enzyme Chewables Natural Mixed Berry Flavor by Pure Encapsulations

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

DigeZyme Multienzyme Complex

50 mg per serving

Other (inactive) ingredients: Xylitol, Mannitol, Maltodextrin, Cellulose, Ascorbyl Palmitate, Natural Mixed Berry Flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzyme Chewables Natural Mixed Berry Flavor by Pure Encapsulations Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Digestive Enzyme Chewables Natural Mixed Berry Flavor. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Digestive Enzyme Chewables Natural Mixed Berry Flavor, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Digestive Enzyme Chewables Natural Mixed Berry Flavor by Pure Encapsulations: Common Questions

Does Digestive Enzyme Chewables Natural Mixed Berry Flavor by Pure Encapsulations interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Digestive Enzyme Chewables Natural Mixed Berry Flavor. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Digestive Enzyme Chewables Natural Mixed Berry Flavor contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest food better?
The evidence is strongest for lactase if you have trouble with milk sugar (lactose intolerance). For the other enzymes in this product—protease, lipase, cellulase, and alpha-amylase—we don't yet have enough reliable data to say whether they work for general digestive support.
Is it safe to take while pregnant?
Protease should be avoided during pregnancy unless your doctor prescribes it. Lipase and lactase have limited safety data in pregnancy, so check with your doctor first to decide what's right for you. The safety of cellulase and alpha-amylase in pregnancy isn't on file for us either.
Can I take it while breastfeeding?
Lactase is considered likely safe while breastfeeding. Protease and lipase aren't recommended without medical advice because of limited safety data. Ask your doctor or pharmacist before using this product regularly while nursing.
What is protease and why is it in here?
Protease is an enzyme that breaks down protein in food. It's included to help your digestive system handle protein more efficiently, though the evidence for its effectiveness isn't yet established in our data.
Can protease cause an allergic reaction?
Rarely, yes. Allergic reactions to protease are uncommon but can include contact dermatitis or breathing problems like allergic rhinitis or asthma. These are mostly seen with occupational powder exposure, not typical supplement use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzyme Chewables Natural Mixed Berry Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzyme Chewables Natural Mixed Berry Flavor label
Sources

Sources & How We Checked

Digestive Enzyme Chewables Natural Mixed Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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