Acti-Zyme By Nature's Plus Overview & Drug Interactions

Bacillus coagulans, also known as Weizmannia coagulans or Lactobacillus sporogenes, is a spore-forming, lactic acid-producing, Gram-positive bacterium used as a probiotic. Bacillus coagulans has shown benefits for constipation and irritable bowel syndrome (IBS). Its spores are stable in stomach acid and reach the small intestine, where they germinate and multiply, with around 85% reaching their destination. The bacterium is excreted via feces, with spores detectable up to 7 days post-administration. Mechanistically, Bacillus coagulans exhibits antibacterial effects through the production of coagulin, lactic acid, and lactosporin, reducing pathogenic bacteria colonization. It also demonstrates antifungal properties and anti-inflammatory effects, potentially reducing the growth of pathogenic bacteria and decreasing the production of lipopolysaccharides. Bacillus coagulans may stimulate immune response, as evidenced by increased CD4+ T cells in adults with HIV-1 infection and modulation of inflammatory cytokines in schoolchildren. These properties categorize Bacillus coagulans as an immunomodulator, immunostimulant, and probiotic, with potential therapeutic applications in promoting digestive health and immune function.

Bromelain is a group of proteolytic enzymes derived from pineapples. It has been traditionally used for its anti-inflammatory and protein-digesting properties. Some research suggests it may have potential benefits for conditions such as allergic rhinitis, burns, cancer, diabetic foot ulcers, and postoperative pain, among others. However, the evidence for its effectiveness in these areas is lacking, and more research is needed. It is important to note that bromelain should not be confused with other protein-digesting enzymes. Pregnant and lactating individuals should avoid using bromelain due to insufficient information about its safety in these populations.

Black pepper is a spice made from the dried, unripe fruit of the Piper nigrum plant, which is native to the southwestern coast of India. It is one of the most widely used spices in the world, and it is often utilized to add flavor and heat to a wide variety of dishes. In traditional medicine, black pepper is purported to have a number of health benefits. It is a good source of antioxidants and is thought to have anti-inflammatory properties, which may make it useful in reducing inflammation and swelling in the body. Black pepper is also used as a natural remedy for digestive problems, such as indigestion and bloating, and to boost the immune system. Black pepper is widely used in dietary supplements, specifically, an extract from black pepper known as piperine. Piperine can affect the absorption of many drugs, which is why it has a large number of reported interactions. Oftentimes, these 'interactions' are purposeful, such as when piperine is used with turmeric, to increase its absorption.