No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Digestive Enzymes 50 mg Smooth Orange Ingredients & Drug Interactions

by EZ Melts

Tablet Or Pill Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Digestive Enzymes 50 mg Smooth Orange is a dietary supplement by EZ Melts with 5 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Digestive Enzymes 50 mg Smooth Orange by EZ Melts

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.

This product has five active digestive enzymes. Lipase breaks down fats; amylase tackles carbohydrates; cellulase works on plant fiber; alpha-galactosidase helps digest complex sugars that can cause gas; and acid protease (a type of protease) breaks down proteins.

These are all naturally occurring enzymes meant to support your digestive process. The remaining ingredients are inactive — mannitol, maltodextrin, maize starch, modified cellulose, natural flavors, plant-based magnesium stearate, monk fruit extract, and silica — which are binders, fillers, and flavoring.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This product is marketed for general wellness, not a specific health condition, so there's no single claim to grade against clinical evidence.

Why this rating?
  • The label markets general wellness (“supports digestive health”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for lipase and acid protease in treating inflammatory bowel disease (IBD), dyspepsia (indigestion), or prematurity is insufficient to rate — we don't have reliable data showing they work for these uses. No effectiveness ratings are on file for amylase, cellulase, or alpha-galactosidase in the data we hold.

The evidence, ingredient by ingredient Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase is generally well tolerated in supplement form, though people with serious digestive conditions should use it only under medical guidance. Acid protease is also generally well tolerated in most adults but may cause digestive upset or allergic reactions in some people.

There is little safety data on supplemental lipase during pregnancy or breastfeeding, so you'll want to talk with your doctor before using it if you're pregnant or nursing. Acid protease safety has not been established in pregnancy and is not recommended during breastfeeding without medical advice.

Rare allergic reactions to proteases have been reported, especially with airborne exposure.

Side effects, ingredient by ingredient Lipase Proteolytic Enzymes (proteases)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. However, we hold no interaction data for amylase, cellulase, or alpha-galactosidase, so it's worth confirming with your pharmacist that this product is safe with any prescription medications you take.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure marketed for general wellness rather than one specific gradeable purpose. No medication interactions are currently documented, and safety information is well characterized.

This product may be worth trying if you're looking for digestive enzyme support, but the evidence for whether it actually works isn't established in the data we hold. If you're pregnant, breastfeeding, or have serious digestive or immune issues, talk with your doctor or pharmacist first — and always run your medications through the checker on this page or confirm with your own pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzymes 50 mg Smooth Orange, straight from the product label.

Brand EZ Melts
Barcode (UPC) 851989007470
Net contents 60 Fast-Melting Tablet(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 231286
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzymes 50 mg Smooth Orange by EZ Melts, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
851989007470
IngredientAmount% DV
Amylase0 NP--
Lipase0 NP--
Cellulase0 NP--
Alpha-Galactosidase0 NP--
Acid Protease0 NP--

Other ingredients: Mannitol, Maltodextrin, Maize Starch, Modified Cellulose, Natural flavors, Plant-based Magnesium Stearate, Monk Fruit extract, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Zero sugar Gluten-free Non-GMO

Vegan

Supports digestive health

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 to 2 tablets before or during a meal or as recommended by your healthcare professional. Allow tablet to dissolve in mouth. No water necessary.

Precautions

If you are pregnant, nursing or taking medication, consult your healthcare professional before use.

Keep out of reach of children.

Storage

Store at room temperature.

General Statements

Dissolvable vitamins

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Digestive Enzymes 50 mg Smooth Orange by EZ Melts label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Digestive Enzymes 50 mg Smooth Orange by EZ Melts

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

0 NP per serving

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Cellulase

0 NP per serving

Alpha-Galactosidase

0 NP per serving

Acid Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Acid Protease monograph & interactions

Other (inactive) ingredients: Mannitol, Maltodextrin, Maize Starch, Modified Cellulose, Natural flavors, Plant-based Magnesium Stearate, Monk Fruit extract, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzymes 50 mg Smooth Orange by EZ Melts Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Digestive Enzymes 50 mg Smooth Orange. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Digestive Enzymes 50 mg Smooth Orange, from the product label.

EZ Melts

See all EZ Melts products
Name
Solara Labs
Street Address
8376 NW 64th St.
City
Miami
State
FL
ZipCode
33166
Phone Number
1-305-477-1325
Web Address
www.ezmelts.net
Pharmacist Counseling Corner

Digestive Enzymes 50 mg Smooth Orange by EZ Melts: Common Questions

Does Digestive Enzymes 50 mg Smooth Orange by EZ Melts interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Digestive Enzymes 50 mg Smooth Orange. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Digestive Enzymes 50 mg Smooth Orange contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does each enzyme in this product do?
Lipase breaks down fats, amylase tackles carbohydrates, cellulase works on plant fiber, alpha-galactosidase helps digest complex sugars that cause gas, and acid protease breaks down proteins. Together they're meant to support overall digestion.
Is this safe during pregnancy?
There isn't enough safety data on lipase during pregnancy, so use it only if your doctor advises it. Acid protease safety has not been established in pregnancy, so it's best avoided unless prescribed. Talk with your doctor for personalized guidance.
Can I take this while breastfeeding?
Safety data during breastfeeding is limited for both lipase and acid protease, so use is not recommended without medical advice. Check with your healthcare provider first.
Does this work for indigestion or digestive problems?
The evidence showing lipase and acid protease work for indigestion or inflammatory bowel disease is insufficient to rate — we don't have reliable data proving they help. You may want to try it and see how you respond, but manage your expectations.
Can I have an allergic reaction to this?
Acid protease may cause allergic reactions in some people, particularly respiratory symptoms like allergic rhinitis or asthma with occupational airborne exposure. Digestive upset is also possible. If you develop any unusual symptoms, stop and talk with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzymes 50 mg Smooth Orange is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzymes 50 mg Smooth Orange label
Sources

Sources & How We Checked

Digestive Enzymes 50 mg Smooth Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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