Digestive Enzymes Ingredients & Drug Interactions
by 21st Century
What is this page for?
First and foremost: checking Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestive Enzymes is a dietary supplement by 21st Century with 7 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Digestive Enzymes by 21st Century
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 7 active digestive enzymes. Protease breaks down proteins, lipase breaks down fats, and lactase breaks down the milk sugar lactose.
The other four — amylase, cellulase, invertase, and maltase — each work on different carbohydrates and starches to aid digestion. The capsule also contains several inactive ingredients (oat fiber, gelatin, silicon dioxide, magnesium silicate, trace minerals, and magnesium stearate) that serve as binders and flow agents.
Does it work?
Strong evidence
Lactase is effective for lactose intolerance — the inability to digest milk sugar — which is the clearest evidence in this product. For the other enzymes (protease, lipase), there is insufficient reliable evidence to rate their effectiveness for digestive complaints like dyspepsia (indigestion) or inflammatory bowel disease.
The data we hold doesn't establish how well they work for general digestive support.
How safe is it?
Well-documented data
Protease, lipase, and lactase are generally well tolerated in most adults, though digestive upset is possible. Rare allergic reactions have been reported, especially in people exposed to concentrated enzyme powders in occupational settings.
During pregnancy, safety data is limited for protease and lipase — talk with your doctor before regular use. For breastfeeding, the same applies: lactase is likely safe (the enzyme acts only in the gut), but ask your doctor or pharmacist first for the other two enzymes.
People with serious digestive conditions should use these enzymes only under medical guidance.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check in this product. Amylase, cellulase, invertase, and maltase were not assessed — you may want to verify these with your pharmacist if you're concerned.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
If you have lactose intolerance, lactase in this product is effective and well tolerated. For general digestive support with the other enzymes, the evidence isn't established.
The product doesn't interact with medications based on what we've checked, but confirm your exact prescriptions with your doctor or pharmacist before starting. People with inflammatory bowel disease or other serious digestive conditions should talk it over with their healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestive Enzymes, straight from the product label.
| Brand | 21st Century |
|---|---|
| Barcode (UPC) | 740985225561 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 304098 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestive Enzymes by 21st Century, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Proprietary Digestive Enzyme Blend | 220 mg | -- |
Other ingredients: Oat Fiber, Gelatin, Silicon Dioxide, Magnesium Silicate, Trace Mineral Complex, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, adults take one (1) capsule daily with any meal or as directed by a healthcare provider. Do not exceed recommended dosage. Individual results may vary.
Precautions
Do not exceed recommended dosage.
Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.
Stop use and contact a physician if adverse reactions occur. Do not use if product appears to be tampered with or seal is broken.
Keep out of reach of children.
Storage
Store at room temperature.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Digestive support
Gluten free Non-GMO
21st Century Digestive Enzymes is a proprietary blend formulated to support normal digestive function.
No added sugar, salt, yeast, artificial flavors or colors.
Guaranteed quality Laboratory tested
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Trusted quality for over 30 years
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestive Enzymes by 21st Century label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestive Enzymes by 21st Century
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Oat Fiber, Gelatin, Silicon Dioxide, Magnesium Silicate, Trace Mineral Complex, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Digestive Enzymes by 21st Century Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Digestive Enzymes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Digestive Enzymes, from the product label.
21st Century
See all 21st Century products- Name
- 21st Century HealthCare, Inc.
- Street Address
- 2119 S. Wilson St.
- City
- Tempe
- State
- AZ
- ZipCode
- 85282
- Web Address
- 21stcenturyvitamins.com
Digestive Enzymes by 21st Century: Common Questions
Does Digestive Enzymes by 21st Century interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product actually help with digestion?
Is it safe to take during pregnancy?
Can I take this while breastfeeding?
What's lactase for?
Are there any side effects?
Does this product have fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestive Enzymes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestive Enzymes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC