EPI Tren-45 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking EPI Tren-45 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
EPI Tren-45 is a dietary supplement by Loud Muscle Science with 1 active ingredient. Its ingredients are commonly taken for building muscle mass, increasing strength, cutting or losing body fat.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Epistane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against EPI Tren-45 by Loud Muscle Science
Ask about any prescription or over-the-counter medication and we check it for interactions with EPI Tren-45 by Loud Muscle Science — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of EPI Tren-45 by Loud Muscle Science
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
EPI Tren-45 contains one active ingredient: epistane, a 17-alpha-alkylated anabolic androgenic steroid. The capsule also contains vegetable cellulose, stearic acid, and less than 2% of other inactive ingredients.
Does it work?
Not established
The evidence we hold does not establish reliable effectiveness for any of epistane's claimed uses — athletic performance, muscle strength, erectile dysfunction, sexual arousal, or obesity. All ratings show insufficient reliable evidence to rate.
How safe is it?
Well-documented data
Epistane is a liver-toxic anabolic steroid, not a safe supplement, and is banned for sale as a dietary supplement. The structure of epistane is similar to another steroid associated with severe liver damage, jaundice, and itching in case reports; those patients did not respond well to standard treatment.
Anabolic steroids must not be used during pregnancy or while breastfeeding because of potential harm to a developing baby or nursing infant.
Meds to double-check
Moderate interaction found
Hepatotoxic drugs — any medication or supplement that can damage the liver — carry a moderate-severity interaction risk with epistane. Check your complete medication list, including over-the-counter and other supplements, before use.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product contains a banned, liver-toxic anabolic steroid with no established effective evidence and serious safety concerns. Pregnancy and breastfeeding are contraindications.
Anyone considering use should speak with their doctor or pharmacist first — especially those with liver disease or taking other medications that affect the liver.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about EPI Tren-45, straight from the product label.
| Brand | Loud Muscle Science |
|---|---|
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 22, 2019 |
| DSLD ID | 210084 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for EPI Tren-45 by Loud Muscle Science, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Epistane | 15 mg | -- |
Other ingredients: Vegetable Cellulose, Stearic Acid, Contains <2% of
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Anabolic muscle volumizer Lean muscle mass Enhanced libido Estrogen control No bloating Dramatic muscularity Optimum muscle pump Fat construction No water retention
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
EPI Tren-45 by Loud Muscle Science label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in EPI Tren-45 by Loud Muscle Science
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Epistane
Interacts with370 drugs
Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been sold as a '...
Epistane monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Stearic Acid, Contains <2% of. These complete the product’s ingredient list but are not active constituents.
EPI Tren-45 by Loud Muscle Science Drug Interactions
HelloPharmacist Interaction Report
EPI Tren-45 contains epistane, a 17-alpha-alkylated anabolic androgenic steroid that carries documented interaction risk with hepatotoxic drugs — those that can damage the liver.
The concern is moderate severity: using epistane alongside other liver-damaging medications could have additive harmful effects on your liver function.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 354 individual medications.
Because epistane itself is a known liver-toxic compound and is structurally similar to another steroid linked to severe liver damage in case reports, the risk of combined liver injury with other hepatotoxic drugs is real. You need to check every medication you take — including over-the-counter drugs and other supplements — before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against EPI Tren-45?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in EPI Tren-45 interact with 370 drugs. Click any drug to see the details.
1 of the 1 ingredient in EPI Tren-45 interact with drugs. Each result below shows which ingredient is responsible. Epistane
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Abacavir, Lamivudine interactionAbiraterone
How Abiraterone interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Abiraterone Acetate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acebutolol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with EPI Tren-45 — through 1 ingredient. Tap an ingredient for the detail:
EpistaneHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in EPI Tren-45 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Epistane
Hepatotoxic Drugs
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Epistane is an anabolic androgenic steroid, and more specifically a 17-alpha-alkylated androgen. Therefore, there is concern that epistane has hepatotoxic effects. Also, epistane is structurally similar to epitiostanol, which has been associated with hepatotixicity in a case series of four patients.
Brand information
Manufacturer and brand details for EPI Tren-45, from the product label.
EPI Tren-45 by Loud Muscle Science: Common Questions
Does EPI Tren-45 by Loud Muscle Science interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take during pregnancy or while breastfeeding?
Does epistane actually work for muscle building or athletic performance?
What's the main safety concern with epistane?
Why do I need to check my medications before taking this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if EPI Tren-45 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind EPI Tren-45’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
EPI Tren-45's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Epistane 3 references
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
- Rahnema CD, Crosnoe LE, Kim ED. Designer steroids - over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology. 2015;3(2):150-5. PubMed
- Díaz FC, Sáez-González E, Benlloch S, et al. Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis. Ann Hepatol. 2016;15(6):939-943.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC