Extra Strength Celery Seed 450 mg 4:1 Extract Ingredients & Drug Interactions
by TerraVita Premium Collection
What is this page for?
First and foremost: checking Extra Strength Celery Seed 450 mg 4:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Extra Strength Celery Seed 450 mg 4:1 Extract is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for high blood pressure, fluid retention (diuretic), joint pain and inflammation.Based on those ingredients, 651 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Celery Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection
Ask about any prescription or over-the-counter medication and we check it for interactions with Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: celery seed extract, a concentrated 4:1 extract providing 450 mg per capsule. The extract is made from celery seeds and prepared to increase potency.
The capsule itself is made from gelatin and water.
Does it work?
Couldn't assess
The evidence for celery seed extract's effectiveness on the conditions listed — sexual dysfunction, anxiety, headache, depression, diabetes, and indigestion — is insufficient to rate. We don't hold established data showing this product works reliably for any of these uses.
How safe is it?
Well-documented data
Celery is generally well tolerated when eaten as food, but concentrated supplements warrant caution due to allergy risk. The most common side effect is photosensitivity — increased sun sensitivity and skin reactions — along with oral allergy syndrome (itching and burning in the mouth and throat) in people with celery sensitivity.
Rarely, anaphylaxis (a severe allergic reaction) has been reported. In pregnancy, medicinal amounts of celery seed should be avoided because it may affect the uterus; everyday food amounts are likely fine.
There isn't enough reliable information on celery supplements while breastfeeding, so it's best avoided during that time.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you use blood thinners or antiplatelet drugs (Coumadin, aspirin, clopidogrel, etc.), thyroid replacement therapy (levothyroxine/Synthroid), antidepressants like venlafaxine (Effexor), blood pressure medications, or lithium. These are the medication types where documented interactions carry the most concern.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Celery seed extract may appeal to you if you're looking for a traditional plant supplement, but the evidence for its effectiveness on common health concerns isn't established in our data. If you take blood thinners, thyroid medication, antidepressants, blood pressure drugs, or lithium, you'll need to check with your doctor or pharmacist before adding this — the interactions are real and could affect how your medications work.
Talk it over with your own healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Extra Strength Celery Seed 450 mg 4:1 Extract, straight from the product label.
| Brand | TerraVita Premium Collection |
|---|---|
| Barcode (UPC) | 064435112271 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 21, 2023 |
| DSLD ID | 285976 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Copyright 2004 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Suggested/Recommended/Usage/Directions
Directions Take 1 capsule, 3 times daily, with meals.
General Statements
TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.
Please recycle!
FDA Disclaimer Statement
Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Celery Seed Extract
Interacts with651 drugs
Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint discomfort....
Celery Seed Extract monograph & interactionsOther (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.
Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection Drug Interactions
HelloPharmacist Interaction Report
TerraVita Premium Collection's Extra Strength Celery Seed Extract has documented interactions with multiple medication types.
The most serious concern is with blood thinners (anticoagulant/antiplatelet drugs) — celery seed contains compounds that may slow blood clotting, raising the theoretical risk of bleeding when combined with these medications.
Read the full breakdown — every affected drug type, severity by severity
Celery seed also interacts moderately with several other drug categories. It may increase blood levels of certain antidepressants (venlafaxine/Effexor), potentially causing mood or neurological changes.
It could reduce the effectiveness of thyroid replacement therapy (levothyroxine/Synthroid) — there are case reports of people whose thyroid symptoms returned after starting celery seed while on this medication. Celery may add to the blood-pressure-lowering effect of antihypertensive drugs, and it might raise levels of drugs your liver metabolizes using a specific pathway (CYP1A2 substrates).
There's also a theoretical risk with lithium, where celery's diuretic properties could raise lithium levels to unsafe ranges.
Minor interactions are documented with photosensitizing medications (drugs that make you sun-sensitive) and acetaminophen (Tylenol). If you take any prescription medication — especially blood thinners, thyroid drugs, psychiatric medications, blood pressure drugs, or lithium — run it through the medication checker on this page before starting.
Altogether, these interactions span 651 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Extra Strength Celery Seed 450 mg 4:1 Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Extra Strength Celery Seed 450 mg 4:1 Extract interact with 651 drugs. Click any drug to see the details.
1 of the 1 ingredient in Extra Strength Celery Seed 450 mg 4:1 Extract interact with drugs. Each result below shows which ingredient is responsible. Celery Seed Extract
AbciximabReoPro
How Abciximab interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Celery Seed Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Celery Seed Extract + Abrocitinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Read the full Celery Seed Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Celery Seed Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAnticoagulant/antiplatelet Drugs, Acetaminophen (tylenol, Others) +1 Moderate
Interaction Summary
Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Celery Seed Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Photosensitizing Drugs +1 Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) +1 Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Acetaminophen (tylenol, Others) +1 Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Photosensitizing Drugs +1 Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Photosensitizing Drugs +1 Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractAcetaminophen (tylenol, Others), Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractPhotosensitizing Drugs, Acetaminophen (tylenol, Others) +1 Moderate
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Photosensitizing Drugs +1 Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractPhotosensitizing Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractPhotosensitizing Drugs, Acetaminophen (tylenol, Others) +1 Moderate
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Extra Strength Celery Seed 450 mg 4:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Celery Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Photosensitizing Drugs +1 Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Seed Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Extra Strength Celery Seed 450 mg 4:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Celery Seed Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Celery root contains the constituents falcarinol and falcarindiol. Laboratory research suggests that these constituents can inhibit platelet aggregation. This effect has not been reported in humans.
Antihypertensive Drugs
Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Clinical research suggests that taking celery seed extract may reduce daytime systolic blood pressure by about 12 mmHg compared to less than 1 mmHg with placebo.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggests that constituents of celery can inhibit CYP1A2. This effect has not been reported in humans.
Levothyroxine (Synthroid, Others)
Theoretically, celery seed might decrease the effects of levothyroxine.
Several cases of hypothyroidism with low T4 levels have been reported in people who were previously stabilized on levothyroxine and then started taking celery seed tablets. They presented with symptoms such as lethargy, bloating, and dry skin, and recovered when celery seed was stopped. However, celery stem and leaf has been associated with case reports of hyperthyroidism in patients with no pre-existing thyroid disorders.
Lithium
Theoretically, celery might reduce excretion and increase levels of lithium due to potential diuretic effects.
Celery is thought to have diuretic properties. However, this effect has not been confirmed in humans.
Venlafaxine (Effexor)
Theoretically, celery root extract might increase blood levels of venlafaxine.
There is one case report of a patient who experienced medication-induced bipolar disorder after beginning to take celery root extract 1000 mg daily along with venlafaxine 75 mg and St. John's wort 600 mg daily. Symptoms included confusion, speech abnormalities, manic affect, and visual hallucinations. The plasma level of venlafaxine was 476.8 ng/mL (normal range 195-400 ng/mL). It is theorized that celery root increased venlafaxine levels by inhibiting cytochrome P450 2D6.
Acetaminophen (Tylenol, Others)
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Animal research suggests that concomitant use of celery juice plus acetaminophen prolongs the effects of acetaminophen. This effect has been attributed to a decrease in hepatic cytochrome P450 activity. However, other animal research shows that pretreatment with celery root extract protects against acetaminophen-induced acute liver failure. These effects have not been reported in humans.
Photosensitizing Drugs
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Laboratory research shows that celery contains photosensitizing agents such as phenols and psoralens.
Brand information
Manufacturer and brand details for Extra Strength Celery Seed 450 mg 4:1 Extract, from the product label.
TerraVita Premium Collection
See all TerraVita Premium Collection products- Name
- TerraVita Fine Whole Herbs
- City
- Brampton
- State
- Ontario
Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection: Common Questions
Does Extra Strength Celery Seed 450 mg 4:1 Extract by TerraVita Premium Collection interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant?
Can I take this while breastfeeding?
What are the side effects I might notice?
Does this product actually work for the conditions listed on the label?
Is there a risk if I'm allergic to celery?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Extra Strength Celery Seed 450 mg 4:1 Extract is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Extra Strength Celery Seed 450 mg 4:1 Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Extra Strength Celery Seed 450 mg 4:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 48 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Celery 48 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
- Moses, G. Thyroxine interacts with celery seed tablets? Australian Prescriber 2001;24:6-7. DOI
- Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
- Jakovljevic, V., Raskovic, A., Popovic, M., and Sabo, J. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur.J Drug Metab Pharmacokinet. 2002;27(3):153-156. PubMed
- Wang, L., Sterling, B., and Don, P. Berloque dermatitis induced by "Florida water". Cutis 2002;70(1):29-30.
- Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. PubMed
- Rueff, F., Eberlein-Konig, B., and Przybilla, B. Oral hyposensitization with celery juice. Allergy 2001;56(1):82-83. PubMed
- Lombaert, G. A., Siemens, K. H., Pellaers, P., Mankotia, M., and Ng, W. Furanocoumarins in celery and parsnips: method and multiyear Canadian survey. J AOAC Int 2001;84(4):1135-1143. DOI
- Ballmer-Weber, B. K., Hoffmann, A., Wuthrich, B., Luttkopf, D., Pompei, C., Wangorsch, A., Kastner, M., and Vieths, S. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy PubMed
- Hoerler, S. and Ukiwe, J. Laryngeal edema from celery allergic reaction. Am.J.Emerg.Med. 1992;10(6):613. PubMed
- DeLeo, V. A. Photocontact dermatitis. Dermatol Ther 2004;17(4):279-288. PubMed
- Groot, B. J., Belinfante-van Gelder, M. E., and Jans, H. W. [An epidemic of dermatitis caused by blanched celery]. Ned.Tijdschr.Geneeskd. 6-20-1992;136(25):1210-1213.
- Erdmann, S. M., Sachs, B., Schmidt, A., Merk, H. F., Scheiner, O., Moll-Slodowy, S., Sauer, I., Kwiecien, R., Maderegger, B., and Hoffmann-Sommergruber, K. In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the b
- Jeanmougin, M., Varroud-Vial, C., and Dubertret, L. [Phototoxic side-effect following celery ingestion during puvatherapy]. Ann.Dermatol Venereol 2005;132(6-7 Pt 1):566-567.
- Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. J Pharm.Biomed.Anal. 6-7-2006;41(3):683-693. PubMed
- Gorgus, E., Lohr, C., Raquet, N., Guth, S., and Schrenk, D. Limettin and furocoumarins in beverages containing citrus juices or extracts. Food Chem.Toxicol. 2010;48(1):93-98. PubMed
- Maso, M. J., Ruszkowski, A. M., Bauerle, J., DeLeo, V. A., and Gasparro, F. P. Celery phytophotodermatitis in a chef. Arch.Dermatol. 1991;127(6):912-913. DOI
- Ljunggren, B. Severe phototoxic burn following celery ingestion. Arch.Dermatol. 1990;126(10):1334-1336. DOI
- Held, J. L. Phytophotodermatitis. Am Fam.Physician 1989;39(4):143-146.
- Silverstein, S. R., Frommer, D. A., Dobozin, B., and Rosen, P. Celery-dependent exercise-induced anaphylaxis. J.Emerg.Med. 1986;4(3):195-199. PubMed
- Rose, M. H. and Altman, L. C. Anaphylaxis after ingestion of raw celery. Ann.Allergy 1985;54(2):166.
- Forsbeck, M. and Ros, A. M. Anaphylactoid reaction to celery. Contact Dermatitis 1979;5(3):191. PubMed
- DeChamp, C., Michel, J., Deviller, P., and Perrin, L. F. [Anaphylactic shock to celery and sensitization to ragweed and mugwort. Crossed or concomitant allergy?]. Presse Med. 3-31-1984;13(14):871-874.
- Johansson, S. G., Dannaeus, A., and Lilja, G. The relevance of anti-food antibodies for the diagnosis of food allergy. Ann.Allergy 1984;53(6 Pt 2):665-672.
- Beier, R. C., Ivie, G. W., Oertli, E. H., and Holt, D. L. HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). Food Chem.Toxicol. 1983;21(2):163-165. PubMed
- Kidd, J. M., III, Cohen, S. H., Sosman, A. J., and Fink, J. N. Food-dependent exercise-induced anaphylaxis. J Allergy Clin Immunol 1983;71(4):407-411. PubMed
- Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. A new French multicenter survey]. Ann.Gastroenterol Hepatol (Paris) 1995;31(4):256-263.
- Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery]. Allerg.Immunol.(Paris) 1995;27(6):209.
- Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery cross-reacting with ragweed]. Allerg.Immunol.(Paris) 1995;27(3):91-93.
- Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. A new French multicenter study]. Bull.Acad.Natl.Med 1995;179(1):161-184.
- Puig, L. and de Moragas, J. M. Enhancement of PUVA phototoxic effects following celery ingestion: cool broth also can burn. Arch.Dermatol. 1994;130(6):809-810. DOI
- Egan, C. L. and Sterling, G. Phytophotodermatitis: a visit to Margaritaville. Cutis 1993;51(1):41-42.
- Boffa, M. J., Gilmour, E., and Ead, R. D. Celery soup causing severe phototoxicity during PUVA therapy. Br.J.Dermatol. 1996;135(2):334.
- Wuthrich, B., Borga, A., and Yman, L. Oral allergy syndrome to a jackfruit (Artocarpus integrifolia). Allergy 1997;52(4):428-431.
- Peterson, S., Lampe, J. W., Bammler, T. K., Gross-Steinmeyer, K., and Eaton, D. L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem.Toxicol. 2006;44(9):147 PubMed
- Baek CH, Bae YJ, Cho YS, Moon HB, Kim TB. Food-dependent exercise-induced anaphylaxis in the celery-mugwort-birch-spice syndrome. Allergy. 2010;65(6):792-3. PubMed
- Khalid Z, Osuagwu FC, Shah B, Roy N, Dillon JE, Bradley R. Celery root extract as an inducer of mania induction in a patient on venlafaxine and St John's Wort. Postgrad Med. 2016;128(7):682-3. PubMed
- Palgan K, Götz-Zbikowska M, Tykwinska M, Napiórkowska K, Bartuzi Z. Celery-cause of severe anaphylactic shock. Postepy Hig Med Dosw (Online). 2012;66:132-4.
- Maljaei MB, Moosavian SP, Mirmosayyeb O, Rouhani MH, Namjoo I, Bahreini A. Effect of celery extract on thyroid function; is herbal therapy safe in obesity? Int J Prev Med 2019;10:55. doi: 10.4103/ijpvm.IJPVM_209_17. PubMed
- Rouhi-Boroujeni H, Hosseini M, Gharipour M, Rouhi-Boroujeni H. Is herbal therapy safe in obesity? A case of Apium graveolens (Celery) induced hyperthyroidism. ARYA Atheroscler 2016;12(5):248-9.
- Emad AM, Ali SF, Abdel-Rahman EA, et al. Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity. J Food Biochem 2020:e13399. Online ahead of print.
- Shayani Rad M, Moohebati M, Mohajeri SA. Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over, clinical trial. Phytother Res 2022.
- Azimi M, Zahedi MJ, Raeiszadeh M, Iraji A, Cramer H, Pasalar M. Efficacy and Safety of a Persian Medicine Formula on Functional Dyspepsia Symptoms: A Randomized Double-Blind Active-Control Clinical Trial. Complement Med Res 2023;30(3):238-247. PubMed
- Ukleja-Sokolowska N, Lis K, Graczyk M, Bartuzi M, Bartuzi Z. The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report. Int J Immunopathol Pharmacol 2024;38:3946320231223004. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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