EZ-Gest Ingredients & Drug Interactions
by Shaklee
What is this page for?
First and foremost: checking EZ-Gest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
EZ-Gest is a dietary supplement by Shaklee with 5 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of EZ-Gest by Shaklee
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
EZ-Gest has five active ingredients: amylase, protease, lipase, lactase, and alpha-galactosidase. These are all digestive enzymes — proteins your body naturally produces to break down food.
Amylase splits carbohydrates, protease breaks down protein, lipase handles fats, lactase breaks down milk sugar, and alpha-galactosidase helps with complex carbohydrates from beans and vegetables. The product also contains inactive ingredients like cellulose, fungal sources for enzyme production, and medium-chain triglyceride oil.
Does it work?
Strong evidence
Lactase, one of the five enzymes here, is effective for lactose intolerance. For the other enzymes — protease, lipase, and the conditions they're used for like general dyspepsia or inflammatory bowel disease — the evidence isn't established in our data.
We don't have effectiveness ratings for amylase or alpha-galactosidase.
How safe is it?
Well-documented data
Protease and lipase are generally well tolerated, though protease may rarely cause allergic reactions or digestive upset, and lipase in adults hasn't been thoroughly studied for safety. Lactase is generally well tolerated and likely safe in pregnancy.
For all three, people with serious digestive conditions should check with a doctor first. During pregnancy, the data for protease and lipase is limited — talk to your doctor before regular use.
During breastfeeding, there's little data on protease and lipase, so ask your healthcare provider before using.
Meds to double-check
No known interactions
No interactions are documented in our data for the digestive enzymes we could check in this product. That doesn't mean none exist — it just means we have no record of them.
Before you start, check your exact medications with the tool on this page, or ask your pharmacist.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
EZ-Gest is a straightforward enzyme blend, particularly useful if you have trouble digesting lactose. If you have a serious digestive condition or you're pregnant or breastfeeding, run this by your doctor first.
No interactions are documented for the enzymes we checked, but it's always smart to let your pharmacist confirm with your exact medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about EZ-Gest, straight from the product label.
| Brand | Shaklee |
|---|---|
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2025 |
| DSLD ID | 334655 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for EZ-Gest by Shaklee, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 14 mg | -- |
| Protease | 21 mg | -- |
| Lipase | 3 mg | -- |
| Lactase | 77 mg | -- |
| Alpha-Galactosidase | 26 mg | -- |
Other ingredients: Microcrystalline Cellulose, Aspergillus oryzae, Aspergillus niger, Rhizopus oryzae, Medium Chain Triglyceride, Hydroxypropyl Methylcellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Comprehensive Digestive Aid Relieves gas, bloating, and feelings of fullness and aids in the digestion of dairy, proteins, fats, and complex carbohydrates.
V Vegan
No artificial flavors, sweeteners, colors, or preservatives
Alleviates digestive discomfort from all food groups
Precautions
Caution: If pregnant, nursing, or galactosemic, and for children under 12 years, consult your physician prior to use.
Caution: If pregnant, nursing, or galactosemic, and for children under 12 years, consult your physician prior to use.
If rare sensitivity to fungal-sourced ingredients occurs, discontinue use.
Seal under cap for your protection.
Seals/Symbols
Shaklee Since 1956 Safe - Proven 100% Guaranteed V Vegan Kosher Star-K (Kosher)
Brand IP Statement(s)
Shaklee Since 1956 Safe - Proven 100% Guaranteed
Formula
Kosher Star-K (Kosher)
General Statements
Dr Shaklee
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take 1 capsule at the start of a meal or as needed as a digestive aid.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
EZ-Gest by Shaklee label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in EZ-Gest by Shaklee
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Amylase
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsLactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsAlpha-Galactosidase
Other (inactive) ingredients: Microcrystalline Cellulose, Aspergillus oryzae, Aspergillus niger, Rhizopus oryzae, Medium Chain Triglyceride, Hydroxypropyl Methylcellulose, Water. These complete the product’s ingredient list but are not active constituents.
EZ-Gest by Shaklee Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in EZ-Gest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for EZ-Gest, from the product label.
Shaklee
See all Shaklee products- Name
- Shaklee Corporation
- City
- Pleasanton
- State
- CA
- ZipCode
- 94566
- Phone Number
- 1.800.742.5533
EZ-Gest by Shaklee: Common Questions
Does EZ-Gest by Shaklee interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does lactase in this product actually work for lactose intolerance?
Can I take this if I'm pregnant?
What if I'm breastfeeding?
Can protease cause allergic reactions?
Are there any inactive ingredients I should know about?
Is this safe if I have a serious digestive condition?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if EZ-Gest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind EZ-Gest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
EZ-Gest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC