No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Formula 1 Protein Digest Ingredients & Drug Interactions

by NESS Nutritional Enzyme Support System

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Formula 1 Protein Digest is a dietary supplement by NESS Nutritional Enzyme Support System with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Formula 1 Protein Digest by NESS Nutritional Enzyme Support System

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Enzyme Blend” is a proprietary blend — the label gives one combined amount (296 mg) without saying how much of each component you get.

This capsule contains four active enzymes designed to support protein and fat digestion. The formula includes protease (which breaks down proteins), lipase (which breaks down fats), amylase (which breaks down carbohydrates), and cellulase (which breaks down plant fiber).

The inactive ingredients are plant fiber and water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: optimize digestion of high-protein diets.
  • We looked for evidence on: Dyspepsia, protein intolerance, digestive enzyme insufficiency, proteolytic insufficiency.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for these enzymes isn't established in our data. Lipase has been studied for inflammatory bowel disease and indigestion, but there isn't enough reliable evidence to rate how well it works for either one.

We don't hold effectiveness ratings for protease, amylase, or cellulase in this product.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lipase are generally well tolerated by most adults but may cause digestive upset or, rarely, allergic reactions — especially if you have a serious digestive condition, in which case use only under medical guidance. Neither has solid safety data in pregnancy or breastfeeding; the facts advise against protease in pregnancy unless prescribed, and recommend checking with your doctor or pharmacist before using lipase during either.

Amylase and cellulase safety data isn't on file here.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented for the ingredients we could check in this product. That said, before you take it, run your medications through the search tool on this page and confirm with your doctor or pharmacist that it won't affect how your drugs work.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

This is an enzyme blend meant to support digestion. It's generally well tolerated, but if you have a serious digestive condition, are pregnant or breastfeeding, or have a known enzyme allergy, talk with your doctor or pharmacist before starting.

They can tell you whether it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Formula 1 Protein Digest, straight from the product label.

Brand NESS Nutritional Enzyme Support System
Barcode (UPC) 707636031148
Net contents 500 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 221168
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Formula 1 Protein Digest by NESS Nutritional Enzyme Support System, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
250
UPC/BARCODE
707636031148
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Proprietary Enzyme Blend296 mg--

Other ingredients: Plant Fiber, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Formulated exclusively for healthcare professionals NESS Protein Digest is uniquely formulated to help optimize the digestion of high-protein diets, minimizing protein intolerance.

Non-GMO

Vegetarian

GMP compliant

Contains No: aspartame, sugar, salt, gluten, artificial colors or flavors, dairy products, wheat, soy, yeast or corn proteins.

Precautions

Caution: If you are pregnant, nursing, have a serious medical condition, or take any medications, consult your physician before use.

Use only if tamper evident seal is unbroken.

Keep out of reach of children.

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure or prevent any disease.

FDA Statement of Identity

Enzyme Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: Take two (2) capsules at the beginning of each meal, or as directed by your healthcare professional.

See for yourself

Formula 1 Protein Digest by NESS Nutritional Enzyme Support System label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Formula 1 Protein Digest by NESS Nutritional Enzyme Support System

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container250 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Enzyme Blend

296 mg per serving

Other (inactive) ingredients: Plant Fiber, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Formula 1 Protein Digest by NESS Nutritional Enzyme Support System Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Formula 1 Protein Digest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Formula 1 Protein Digest, from the product label.

NESS Nutritional Enzyme Support System

See all NESS Nutritional Enzyme Support System products
Name
Enzymes Inc.
City
Kansas City
State
MO
ZipCode
64153
Phone Number
1-800-637-7893
Web Address
www.nessenzymes.com
Pharmacist Counseling Corner

Formula 1 Protein Digest by NESS Nutritional Enzyme Support System: Common Questions

Does Formula 1 Protein Digest by NESS Nutritional Enzyme Support System interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Formula 1 Protein Digest. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Formula 1 Protein Digest contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is protease safe during pregnancy?
Safety data for protease in pregnancy is limited. The facts advise against it during pregnancy unless your doctor has prescribed it. Talk with your doctor or pharmacist about whether it's right for you.
Can I take this while breastfeeding?
There isn't much safety data on protease or lipase during breastfeeding. Both ingredients recommend checking with your healthcare provider first before using them.
What side effects might I notice?
Most people tolerate these enzymes well, but digestive upset can happen. Rarely, allergic reactions have been reported — especially with occupational exposure to protease in products like laundry detergent or as airborne pepsin.
Does lipase work for indigestion or digestive conditions?
Lipase has been studied for indigestion and inflammatory bowel disease, but there isn't enough reliable evidence yet to say how well it works for either.
What if I have a serious digestive condition like IBD?
If you have a serious digestive condition, use lipase only under medical guidance. Talk with your doctor or pharmacist first to make sure it's appropriate for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Formula 1 Protein Digest is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Formula 1 Protein Digest label
Sources

Sources & How We Checked

Formula 1 Protein Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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