Formula 20 Digest Ingredients & Drug Interactions
by NESS Nutritional Enzyme Support System
What is this page for?
First and foremost: checking Formula 20 Digest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Formula 20 Digest is a dietary supplement by NESS Nutritional Enzyme Support System with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Formula 20 Digest by NESS Nutritional Enzyme Support System
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Formula 20 Digest has four active enzyme ingredients. Protease breaks down proteins; lipase breaks down fats; amylase breaks down carbohydrates; and cellulase breaks down fiber.
Together they're meant to support your digestive system. The product also contains plant fiber and water as inactive ingredients.
Does it work?
Not established
The evidence for what these enzymes actually do isn't established in the data we hold. For lipase, the research on whether it helps with inflammatory bowel disease or indigestion is rated insufficient — we don't have enough reliable studies to say whether it works.
We have no effectiveness ratings on file for protease, amylase, or cellulase in this product.
How safe is it?
Well-documented data
Protease and lipase are generally well tolerated by most adults, though some people report digestive upset or allergic reactions — rarely, people with occupational exposure to airborne protease have developed allergies or asthma-like symptoms. Neither ingredient has adequate safety data in pregnancy; protease should be avoided unless prescribed by your doctor, and lipase use in pregnancy should only happen if your doctor advises it.
For breastfeeding, protease is not recommended without medical advice, and lipase safety hasn't been well studied — check with your healthcare provider first. We hold no safety data on amylase or cellulase.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, if you take any medications affecting digestion, blood clotting, or diabetes control, confirm with your pharmacist or doctor before starting this product.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
This is an enzyme supplement intended to support digestion. If you have serious digestive conditions, check with your doctor before starting.
If you're pregnant or breastfeeding, talk with your healthcare provider first — the safety data on these enzymes during those times is limited. Run any medications you take through the interaction checker on this page before you begin.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Formula 20 Digest, straight from the product label.
| Brand | NESS Nutritional Enzyme Support System |
|---|---|
| Barcode (UPC) | 707636033029 |
| Net contents | 180 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 221301 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Formula 20 Digest by NESS Nutritional Enzyme Support System, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Proprietary Enzyme Blend | 121 mg | -- |
Other ingredients: Plant Fiber, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Formulated exclusively for healthcare professionals NESS Digest is uniquely formulated to help optimize the digestion of protein, carbohydrates, fat, and fiber in the diet.
Non-GMO
Vegetarian
GMP compliant
Contains No: Aspartame, sugar, salt, gluten, artificial colors or flavors, dairy products, wheat, soy, yeast or corn proteins.
Precautions
Caution: If you are pregnant, nursing, have a serious medical condition, or take any medications, consult your physician before use.
Use only if tamper evident seal is unbroken.
Keep out of reach of children.
Storage
Store tightly closed in a cool, dry place.
FDA Disclaimer Statement
These statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure or prevent any disease.
FDA Statement of Identity
Enzyme Supplement
Suggested/Recommended/Usage/Directions
Recommended Use: Take two (2) capsules at the beginning of each meal, or as directed by your healthcare professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Formula 20 Digest by NESS Nutritional Enzyme Support System label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Formula 20 Digest by NESS Nutritional Enzyme Support System
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Plant Fiber, Water. These complete the product’s ingredient list but are not active constituents.
Formula 20 Digest by NESS Nutritional Enzyme Support System Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Formula 20 Digest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Formula 20 Digest, from the product label.
NESS Nutritional Enzyme Support System
See all NESS Nutritional Enzyme Support System products- Name
- Enzymes Inc.
- City
- Kansas City
- State
- MO
- ZipCode
- 64153
- Phone Number
- 1-800-637-7893
- Web Address
- www.nessenzymes.com
Formula 20 Digest by NESS Nutritional Enzyme Support System: Common Questions
Does Formula 20 Digest by NESS Nutritional Enzyme Support System interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does each enzyme in this product do?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
Can protease cause allergic reactions?
Does this product have fillers?
Does lipase help with indigestion or inflammatory bowel disease?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Formula 20 Digest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Formula 20 Digest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Formula 20 Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC