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Dietary supplement

Free Form L-Glycine Unflavored Ingredients & Drug Interactions

by Muscle Feast

Powder Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Free Form L-Glycine Unflavored is a dietary supplement by Muscle Feast with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Free Form L-Glycine Unflavored by Muscle Feast

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is pure L-glycine — a single amino acid, the building block of protein. There are no inactive ingredients or fillers listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Glycine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: heart health, brain function, improved sleep.
  • We looked for evidence on: Cognitive function, Insomnia, Physical performance, Stroke, sleep quality, mental clarity — and 1 related terms.
  • The closest evidence on file: Glycine is rated "Insufficient Reliable Evidence To Rate" for Cognitive function (Natural Medicines).
  • Also on file: Glycine is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stroke, Physical performance.

The evidence is clearest for schizophrenia, where glycine is rated possibly effective as an add-on therapy. For other uses — low 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (BPH), and cystic fibrosis — we don't have enough reliable evidence to rate it.

If you're considering glycine for any of those conditions, your doctor can help weigh what little evidence exists against your individual situation.

The evidence, ingredient by ingredient Glycine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glycine is generally well tolerated at typical doses, but long-term safety data are limited, so if you plan to use it long-term, check in with your doctor. A small number of trial participants reported mild sedation, irritability, insomnia, fatigue, memory impairment, headache, sensory changes, soft stools, nausea, vomiting, upper stomach discomfort, or dry mouth — these are rare and usually clear quickly if you stop taking it.

Data on safety during pregnancy and breastfeeding aren't on file, so talk with your doctor or pharmacist about whether to use it if you're pregnant, trying to conceive, or nursing.

Side effects, ingredient by ingredient Glycine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glycine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication to watch for is clozapine (Clozaril), an antipsychotic — glycine may worsen schizophrenia symptoms if you're already on it. If you take clozapine or any other regular medication, confirm with your doctor or pharmacist before you start this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Muscle Feast L-Glycine is a straightforward single-ingredient supplement that's generally well tolerated. If you take clozapine or any other prescription medication, check with your doctor or pharmacist first — the interaction with clozapine is the main concern.

For most other uses, evidence is still being built, so it's worth discussing your reason for taking it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Free Form L-Glycine Unflavored, straight from the product label.

Brand Muscle Feast
Net contents 7 Ounce(s); 200 Gram(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 262376
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Free Form L-Glycine Unflavored by Muscle Feast, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4.3 Gram(s)
Maximum serving Sizes:
4.3 Gram(s)
Servings per container
46
IngredientAmount% DV
L-Glycine4300 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Muscle Feast L-Glycine is an amino acid that plays a critical role in the body's production of glutathione, creatine, and collagen. Individuals that supplement with glycine may see many benefits, including protection against muscle loss, increased brain function, protection of the liver and heart, and it may even improve sleep quality.

Suggested/Recommended/Usage/Directions

Suggested use: As an adult dietary supplement, take one 5cc serving (4.3g) one to three times daily with water or fruit juice. Mix 1 serving (4.3g) with water or fruit juice up to 3 times a day.

Formulation

Non-GMO

Certified Vegan AVA American Vegetarian Association

Heart health Brain function Improved sleep

Seals/Symbols

Made in Our GMP Compliant Facility Made in an FDA Registered Facility Certified Vegan AVA American Vegetarian Association

General Statements

SDVOSB Service Distributed Veteran Owned Small Business 46 Servings

Ohio Family Owned Business

FDA Statement of Identity

Dietary Supplement

Storage

Keep tightly closed in a cool, dry place away from sunlight.

Precautions

Keep out of reach of children.

Do not exceed the recommended dose. Consult your physician before using this product.

Do not use this product if you are pregnant or nursing. Do not use this product if you are taking any prescription medication.

Do not use this product if you are under the age of 18.

Warning: This product is manufactured in a GMP compliant plant that processes milk.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Free Form L-Glycine Unflavored by Muscle Feast label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Free Form L-Glycine Unflavored by Muscle Feast

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4.3 Gram(s) Dosage formPowder Servings per container46 Amounts shown are per serving.

L-Glycine

Interacts with
1 drug
4300 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

L-Glycine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Free Form L-Glycine Unflavored by Muscle Feast Drug Interactions

Want to check YOUR meds against Free Form L-Glycine Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Free Form L-Glycine Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
The maker

Brand information

Manufacturer and brand details for Free Form L-Glycine Unflavored, from the product label.

Muscle Feast

See all Muscle Feast products
Name
Muscle Feast
Street Address
1320 Boston Road
City
Nashport
State
OH
ZipCode
43830
Phone Number
(888) 734-3634
Web Address
www.musclefeast.com
Pharmacist Counseling Corner

Free Form L-Glycine Unflavored by Muscle Feast: Common Questions

Does Free Form L-Glycine Unflavored by Muscle Feast interact with any medications?
Yes. Based on its ingredients, Free Form L-Glycine Unflavored has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Free Form L-Glycine Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on clozapine for schizophrenia?
No — talk with your doctor first. A small study showed that adding glycine to clozapine actually worsens schizophrenia symptoms. Your doctor may advise against it or may monitor you closely if there's a strong reason to try it together.
Does L-glycine actually help with schizophrenia?
The evidence suggests it may help, but only as an add-on to other schizophrenia medication — not on its own. The interaction with clozapine is a complication, so work closely with your doctor if schizophrenia is why you're considering it.
Is it safe to use long-term?
It's generally well tolerated at typical doses, but we don't have much data on long-term safety. If you're thinking of taking it for months or years, mention it to your doctor.
What side effects might I notice?
They're rare, but a small number of people report mild sedation, irritability, insomnia, fatigue, headache, soft stools, nausea, or dry mouth. These usually go away quickly if you stop taking it.
Is it safe during pregnancy or breastfeeding?
We don't have enough safety data to know either way. If you're pregnant, trying to conceive, or nursing, talk with your doctor or pharmacist about whether this is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Free Form L-Glycine Unflavored is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Free Form L-Glycine Unflavored label
Go deeper

The Full Monographs Behind Free Form L-Glycine Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Free Form L-Glycine Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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