GI Digest Ingredients & Drug Interactions
What is this page for?
First and foremost: checking GI Digest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
GI Digest is a dietary supplement by Douglas Laboratories with 10 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of GI Digest by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
GI Digest is a 10-ingredient digestive enzyme blend. The checked active ingredients include protease (breaks down protein), lipase (breaks down fat), and lactase (breaks down lactose in milk), along with amylase and several other carbohydrate-digesting enzymes.
The product also contains two proprietary enzyme blends—BioCore Optimum Complete and BioCore DPP-IV—designed to support broader digestive function. The remaining inactive ingredients are standard capsule materials and fillers.
Does it work?
Strong evidence
Lactase in this product is effective for lactose intolerance (difficulty digesting milk sugar). The other active ingredients—protease, lipase, and the broader enzyme blend—have insufficient reliable evidence to rate their effectiveness for inflammatory bowel disease or indigestion (dyspepsia) according to the data we hold.
If you're taking this for a specific digestive condition, talk with your doctor or pharmacist about whether the evidence supports its use for your situation.
How safe is it?
Well-documented data
Protease, lipase, and lactase are generally well tolerated when used as directed. Protease and lipase can occasionally cause digestive upset, and protease carries a rare risk of allergic reaction—case reports link occupational airborne exposure to allergic rhinoconjunctivitis (sinus and eye inflammation) and asthma, though dietary supplement exposure is different.
Lactase is likewise generally well tolerated; one rare case of allergic contact dermatitis and nasal allergy to powdered lactase was reported in an occupational setting. During pregnancy, protease safety has not been established and is best avoided unless prescribed.
Lipase has limited pregnancy safety data, so use only if your doctor advises it. Lactase is likely safe in pregnancy.
For breastfeeding, protease and lipase lack sufficient safety data—check with your healthcare provider first. Lactase is presumed safe since it acts only in the gut, but confirm with your doctor or pharmacist.
We hold no pregnancy or breastfeeding data for the other ingredients.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we hold no interaction data for amylase, peptidase, invertase, glucoamylase, alpha-galactosidase, acid maltase, or BioCore DPP-IV.
Use the medication checker on this page to search your specific drugs, and talk with your doctor or pharmacist if you take any prescription medication.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
GI Digest is a multi-enzyme supplement most useful if you have lactose intolerance; its effectiveness for other digestive complaints isn't well established. If you're pregnant, breastfeeding, or have a serious digestive condition, clear it with your doctor or pharmacist first—especially protease and lipase, which lack robust safety data in those situations.
No medication interactions are documented for the ingredients we could check, but confirm your exact drugs with the search tool on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about GI Digest, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Barcode (UPC) | 310539038895 |
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2020 |
| DSLD ID | 232291 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for GI Digest by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Acid Maltase | 0 NP | -- |
| BioCore Optimum Complete | 110 mg | -- |
| BioCore DPP-IV | 100 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Vegetable Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 capsule with each meal or as directed by your health professional.
Precautions
Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.
Keep out of the reach of children.
Use only if safety seal is intact.
Brand IP Statement(s)
BioCore and Biocore DPP-IV are registered trademarks of Deerland Probiotics & Enzymes
Storage
Store in a cool, dry place.
Formulation
Gluten-free, Non-GMO
Comprehensive digestive enzyme formula
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our manufacturing excellence
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
GI Digest by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in GI Digest by Douglas Laboratories
These are the 10 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
BioCore Optimum Complete
BioCore DPP-IV
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
GI Digest by Douglas Laboratories Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in GI Digest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for GI Digest, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Phone Number
- 1.800.245.4440
- Web Address
- www.douglaslabs.com
GI Digest by Douglas Laboratories: Common Questions
Does GI Digest by Douglas Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is lactase in this product effective for lactose intolerance?
Can I take GI Digest while pregnant?
Is it safe to breastfeed while taking GI Digest?
What does protease do?
What are the inactive ingredients?
Does this product work for inflammatory bowel disease or indigestion?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if GI Digest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind GI Digest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
GI Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC