Ginkgold Eyes 60 mg Ingredients & Drug Interactions
by Nature's Way
What is this page for?
First and foremost: checking Ginkgold Eyes 60 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ginkgold Eyes 60 mg is a dietary supplement by Nature's Way with 4 active ingredients. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 1,268 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Ginkgold, Bilberry Extract, Zeaxanthin Carotenoid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ginkgold Eyes 60 mg by Nature's Way
Ask about any prescription or over-the-counter medication and we check it for interactions with Ginkgold Eyes 60 mg by Nature's Way — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ginkgold Eyes 60 mg by Nature's Way
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Ginkgold Eyes contains 5 active ingredients designed to support eye and cognitive health. The main ingredient is ginkgo flavone glycosides from ginkgo leaf extract, paired with three supporting carotenoids and antioxidants: lutein, zeaxanthin, and a bilberry extract blend that includes anthocyanins and terpene lactones.
The remaining ingredients are inactive fillers (cellulose, hydroxypropyl cellulose, sodium croscarmellose, stearic acid, silica, hypromellose, and glycerin) that form the tablet.
Does it work?
Moderate evidence
The ginkgo in this product is possibly effective for hearing loss, stroke recovery, schizophrenia, premenstrual syndrome (PMS), dementia, and anxiety, though the evidence is modest. Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts but appears ineffective for retinitis pigmentosa, necrotizing enterocolitis, retinopathy of prematurity, and bronchopulmonary dysplasia.
Zeaxanthin is possibly effective for AMD but has insufficient evidence for cognitive decline, Alzheimer's disease, asthma, breast cancer, and bronchopulmonary dysplasia. We don't have effectiveness data on anthocyanins or terpene lactones from the bilberry extract.
How safe is it?
Well-documented data
Ginkgo leaf extract is generally well tolerated when used for up to 6 years, though it does carry a bleeding risk and should be used with caution—avoid the seed and crude plant, which contain toxic substances. The most common side effects are dizziness and stomach upset.
Rare but serious concerns include cardiac arrhythmias and spontaneous bleeding, especially in people already at higher bleeding risk or taking other blood thinners or anticoagulants. The safety data advises against ginkgo during pregnancy due to insufficient safety data and possible bleeding risk, and it should be avoided while breastfeeding.
Lutein and zeaxanthin are generally well tolerated at typical supplement doses; lutein is likely safe in pregnancy and lactation, though supplement (not food) doses haven't been well studied during breastfeeding. Zeaxanthin is also likely safe in pregnancy and lactation, but concentrated supplement safety while breastfeeding isn't well established.
Meds to double-check
Major interaction found
Before you take this product, double-check with your pharmacist if you're on a blood-pressure medication called talinolol, blood thinners like warfarin, anxiety medications like alprazolam, antidepressants like trazodone, cholesterol drugs like simvastatin, HIV medications like efavirenz, diabetes medications like rosiglitazone, or transplant rejection drugs like tacrolimus. Zeaxanthin may also interact with diabetes medications and increase the risk of low blood sugar.
If you're on any prescription medication, use the search tool on this page to check your exact drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product may help with vision and cognitive function if you have age-related macular degeneration, anxiety, dementia, or PMS. However, if you take a blood thinner, heart medication, anxiety medication, antidepressant, diabetes drug, or transplant rejection medicine, you need to check with your pharmacist first—ginkgo interacts with many common medications and increases bleeding risk.
Pregnant or breastfeeding? Talk to your pharmacist or doctor before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ginkgold Eyes 60 mg, straight from the product label.
| Brand | Nature's Way |
|---|---|
| Barcode (UPC) | 033674152522 |
| Net contents | 60 Vegan Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2025 |
| DSLD ID | 327972 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ginkgold Eyes 60 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Anthocyanins | 43.2 mg | -- |
| Bilberry Extract | 120 mg | -- |
| Terpene Lactones | 3.6 mg | -- |
| Ginkgo Flavone Glycosides | 14.4 mg | -- |
| Lutein Carotenoid | 20 mg | -- |
| Zeaxanthin Carotenoid | 1 mg | -- |
| Ginkgold | 60 mg | -- |
Other ingredients: Cellulose, Hydroxypropyl Cellulose, Sodium Croscarmellose, Stearic Acid, Silica, Hypromellose, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Premium blend formulated for eye health Supports visual function Supports the retina's ability to adapt to light and dark conditions Supports antioxidant pathways to help protect against free radicals
Gluten free. No wheat, soy, dairy, or gelatin.
Vegan Gelatin free
Bottled and tested in the USA
Supports eye health Plant powered
Vegan Gelatin Free
Formula
With carotenoids lutein and zeaxanthin that are critical to a healthy macula
Advanced ginkgo extract 60 mg ginkgo extract per 2 tablets
Precautions
Keep out of reach of children.
Safety sealed with inner seal. Do not use if seal is broken or missing.
Warning: Do not take if you are pregnant or nursing. If you have a seizure disorder, bleeding disorder, or if you are taking blood thinners or other medications, consult a healthcare professional before use.
Discontinue use one week prior to surgery.
Storage
Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
General Statements
Bottle made from 50% post-consumer recycled plastic
Brand IP Statement(s)
Copyright 2023 Nature's Way Brands, LLC
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Adults take 2 tablets daily with water at mealtime. May be used in conjunction with up to 180 mg of Ginkgo biloba Extract.
Seals/Symbols
Vegan Gelatin Free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ginkgold Eyes 60 mg by Nature's Way label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ginkgold Eyes 60 mg by Nature's Way
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Bilberry Extract
Interacts with275 drugs
Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...
Bilberry Extract monograph & interactions- › Anthocyanins
Lutein Carotenoid
No knowninteractions
Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...
Lutein Carotenoid monograph & interactionsZeaxanthin Carotenoid
Interacts with86 drugs
Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...
Zeaxanthin Carotenoid monograph & interactionsGinkgold
Interacts with1,266 drugs
Ginkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation. The evidence for these uses is mixed and...
Ginkgold monograph & interactions- › Terpene Lactones
- › Ginkgo Flavone Glycosides
Other (inactive) ingredients: Cellulose, Hydroxypropyl Cellulose, Sodium Croscarmellose, Stearic Acid, Silica, Hypromellose, Glycerin. These complete the product’s ingredient list but are not active constituents.
Ginkgold Eyes 60 mg by Nature's Way Drug Interactions
HelloPharmacist Interaction Report
Ginkgold Eyes by Nature's Way contains ginkgo flavone glycosides, which interact with a number of medications.
The most serious concern is talinolol (a beta-blocker for high blood pressure): taking ginkgo with talinolol seems to increase blood levels of talinolol by about 36% when you use the extract regularly, which could raise side effects like fatigue or low blood pressure.
Read the full breakdown — every affected drug type, severity by severity
Ginkgo also has moderate interactions with several other drug types. Blood thinners like warfarin (Coumadin) carry a heightened bleeding risk—ginkgo appears to thin the blood further by interfering with how platelets clump together.
Anxiety medications like alprazolam (Xanax) and the antidepressant trazodone may have their levels decreased or, in trazodone's case, increased to dangerous levels. Cholesterol drugs (simvastatin), HIV antiretrovirals (efavirenz), diabetes drugs (rosiglitazone), and transplant rejection medications (tacrolimus) all have documented interactions with ginkgo as well.
Zeaxanthin, another ingredient in this product, may theoretically increase the risk of low blood sugar (hypoglycemia) if you're on diabetes medications, though population studies haven't confirmed this risk.
We could not check anthocyanins and terpene lactones—we hold no data for them. Lutein has no interactions documented in our data.
Altogether, these interactions span 1,251 individual medications. Run your exact medications through the checker below before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ginkgold Eyes 60 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ginkgold Eyes 60 mg interact with 1,268 drugs. Click any drug to see the details.
3 of the 4 ingredients in Ginkgold Eyes 60 mg interact with drugs. Each result below shows which ingredient is responsible. Ginkgold Bilberry Extract Zeaxanthin Carotenoid
TalinololTalinolol
How Talinolol interacts with Ginkgold Eyes 60 mg — through 1 ingredient. Tap an ingredient for the detail:
GinkgoldTalinolol Major
Interaction Summary
Taking ginkgo with talinolol seems to increase blood levels of talinolol.
Read the full Ginkgold + Talinolol interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Ginkgold Eyes 60 mg — through 1 ingredient. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin.
Read the full Ginkgold + Abciximab interactionBilberry ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Ginkgold Eyes 60 mg — through 1 ingredient. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Ginkgold Eyes 60 mg — through 1 ingredient. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Ginkgold Eyes 60 mg — through 1 ingredient. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin.
Read the full Ginkgold + Abrocitinib interactionBilberry ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Ginkgold Eyes 60 mg — through 1 ingredient. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Ginkgold Eyes 60 mg — through 3 ingredients. Tap an ingredient for the detail:
Bilberry ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bilberry Extract + Acarbose interactionGinkgoldAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ginkgo with antidiabetes drugs might alter the response to antidiabetes drugs.
Read the full Ginkgold + Acarbose interactionZeaxanthin CarotenoidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Zeaxanthin Carotenoid + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Extract + Acenocoumarol interactionGinkgoldAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin.
Read the full Ginkgold + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen interactionGinkgoldCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen, Aspirin interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Extract + Acetaminophen, Aspirin, Caffeine interactionGinkgoldAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin.
Read the full Ginkgold + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 1a2 (cyp1a2) Substrates, Seizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Butalbital interactionGinkgoldCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen, Butalbital, Caffeine interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionGinkgoldSeizure Threshold Lowering Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgold + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Butalbital, Codeine interactionGinkgoldSeizure Threshold Lowering Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgold + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 1a2 (cyp1a2) Substrates, Seizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen, Butalbital, Codeine Phosphate interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldSeizure Threshold Lowering Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgold + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Caffeine, Codeine interactionGinkgoldSeizure Threshold Lowering Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgold + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Acetaminophen, Caffeine, Codeine, Salicylamide interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionGinkgoldSeizure Threshold Lowering Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgold + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen, Caffeine, Isometheptene interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Acetaminophen, Caffeine, Pyrilamine interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionGinkgoldCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgold + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates, Seizure Threshold Lowering Drugs +1 Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldSeizure Threshold Lowering Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgold + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates, Seizure Threshold Lowering Drugs +1 Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Ginkgold Eyes 60 mg — through 2 ingredients. Tap an ingredient for the detail:
GinkgoldCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
Read the full Ginkgold + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionBilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ginkgold Eyes 60 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Ginkgold
Talinolol
Taking ginkgo with talinolol seems to increase blood levels of talinolol.
There is some evidence that using ginkgo leaf extract 120 mg orally three times daily for 14 days can increase levels of talinolol by 36% in healthy male individuals. However, single doses of ginkgo do not seem to affect talinolol pharmacokinetics.
Alprazolam (Xanax)
Theoretically, ginkgo might decrease the levels and clinical effects of alprazolam.
In clinical research, ginkgo extract (Ginkgold) 120 mg twice daily seems to decrease alprazolam levels by about 17%. However, ginkgo does not appear to decrease the elimination half-life of alprazolam. This suggests that ginkgo is more likely to decrease absorption of alprazolam rather than induce hepatic metabolism of alprazolam.
Anticoagulant/Antiplatelet Drugs
Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin. Theoretically, ginkgo might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Several pharmacodynamic studies suggest that ginkgo inhibits platelet aggregation. It is thought that the ginkgo constituent, ginkgolide B, displaces platelet-activating factor (PAF) from its binding sites, decreasing blood coagulation. Several case reports have documented serious bleeding events in patients taking ginkgo. However, population and clinical studies have produced mixed results. Some evidence shows that short-term use of ginkgo leaf does not significantly reduce platelet aggregation and blood clotting. A study in healthy males who took a specific ginkgo leaf extract (EGb 761) 160 mg twice daily for 7 days found no change in prothrombin time. An analysis of a large medical record database suggests that ginkgo increases the risk of a bleeding adverse event by 38% when taken concurrently with warfarin. It has been suggested that ginkgo has to be taken for at least 2-3 weeks to have a significant effect on platelet aggregation. However, a meta-analysis of 18 studies using standardized ginkgo extracts, 80-480 mg daily for up to 32 weeks, did not find a significant effect on platelet aggregation, fibrinogen concentration, or PT/aPTT. In addition, a single dose of ginkgo plus clopidogrel or ticlopidine does not seem to significantly increase bleeding time or platelet aggregation. Also, taking ginkgo leaf extract daily for 8 days in conjunction with rivaroxaban does not affect anti-factor Xa activity; however, this study did not evaluate bleeding time.
Anticonvulsants
Theoretically, ginkgo might reduce the effectiveness of anticonvulsants.
Ginkgo seeds contain ginkgotoxin. Large amounts of ginkgotoxin can cause neurotoxicity and seizure. Ginkgotoxin is present in much larger amounts in ginkgo seeds than leaves. Ginkgo leaf extract contains trace amounts of ginkgotoxin. The amount of ginkgotoxin in ginkgo leaf and leaf extract seems unlikely to cause toxicity. However, there are anecdotal reports of seizure occurring after use of ginkgo leaf both in patients without a history of seizure disorder and in those with previously well-controlled epilepsy.
Antidiabetes Drugs
Theoretically, taking ginkgo with antidiabetes drugs might alter the response to antidiabetes drugs.
Ginkgo leaf extract seems to alter insulin secretion and metabolism, and might affect blood glucose levels in people with type 2 diabetes. The effect of ginkgo seems to differ depending on the insulin and treatment status of the patient. In diet-controlled diabetes patients with hyperinsulinemia, taking ginkgo does not seem to significantly affect insulin or blood glucose levels. In patients with hyperinsulinemia who are treated with oral hypoglycemic agents, taking ginkgo seems to decrease insulin levels and increase blood glucose following an oral glucose tolerance test. Researchers speculate that this could be due to ginkgo-enhanced hepatic metabolism of insulin. In patients with pancreatic exhaustion, taking ginkgo seems to stimulate pancreatic beta-cells, resulting in increased insulin and C-peptide levels, but with no significant change in blood glucose levels in response to an oral glucose tolerance test.
Atorvastatin (Lipitor)
Theoretically, ginkgo might decrease the levels and clinical effects of atorvastatin.
In humans, intake of ginkgo extract appears to increase atorvastatin clearance, reducing the area under the curve of atorvastatin by 10% to 14% and the maximum concentration by 29%. However, this interaction does not appear to affect cholesterol synthesis and absorption. Further, a model in rats with hyperlipidemia suggests that administering ginkgo extract does not impact blood levels of atorvastatin and leads to lower total cholesterol, low-density lipoprotein cholesterol, and triglycerides when compared with rats given atorvastatin alone.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that ginkgo leaf extract can mildly inhibit CYP1A2 enzymes. However, clinical research suggests ginkgo might not affect CYP1A2. Until more is known, use ginkgo cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP2C19.
Some clinical research shows that a specific ginkgo leaf extract (Remembrance, Herbs Product LTD) 140 mg twice daily can induce CYP2C19 enzymes and potentially decrease levels of drugs metabolized by these enzymes. However, other clinical research shows that taking ginkgo 120 mg twice daily for 12 days has no effect on levels of drugs metabolized by CYP2C19.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, ginkgo might increase levels of drugs metabolized by CYP2C9.
In vitro, a specific standardized extract of ginkgo leaf (EGb 761) inhibits CYP2C9 activity . The terpenoid (ginkgolides) and flavonoid (quercetin, kaempferol, etc.) constituents seem to be responsible for this effect. Most ginkgo extracts contain some amount of these constituents. Therefore, other ginkgo leaf extracts might also inhibit the CYP2C9 enzyme. However, clinical research suggests that ginkgo might not have a significant effect on CYP2C9 in humans. Ginkgo does not seem to significantly affect the pharmacokinetics of CYP2C9 substrates diclofenac or tolbutamide.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
There is conflicting evidence about whether ginkgo induces or inhibits CYP3A4. Ginkgo does not appear to affect hepatic CYP3A4. However, it is not known if ginkgo affects intestinal CYP3A4. Preliminary clinical research suggests that taking ginkgo does not significantly affect levels of donepezil, lopinavir, or ritonavir, which are all CYP3A4 substrates. Other clinical research also suggests ginkgo does not significantly affect CYP3A4 activity. However, there are two case reports of decreased efavirenz concentrations and increased viral load in patients taking ginkgo. It is suspected that terpenoids from the ginkgo extract reduced drug levels by inducing cytochrome P450 3A4 (CYP3A4).
Efavirenz (Sustiva)
Theoretically, ginkgo might decrease the levels and clinical effects of efavirenz.
There are two case reports of decreased efavirenz concentrations and increased viral load in patients taking ginkgo. In one case, an HIV-positive male experienced over a 50% decrease in efavirenz levels over the course of 14 months while taking ginkgo extract. HIV-1 RNA copies also increased substantially, from less than 50 to more than 1500. It is suspected that terpenoids from the ginkgo extract reduced drug levels by inducing cytochrome P450 3A4 (CYP3A4). In another case report, a patient stable on antiviral therapy including efavirenz for 10 years, had an increase in viral load from <50 copies/mL to 1350 copies/mL after 2 months of taking a combination of supplements including ginkgo. After stopping ginkgo, the viral load was again controlled with the same antiviral therapy regimen.
Ibuprofen (Advil, Others)
Theoretically, ginkgo might increase the risk of bleeding when used with ibuprofen.
Ginkgo might have antiplatelet effects and has been associated with several case reports of spontaneous bleeding. In one case, a 71-year-old male had taken a specific ginkgo extract (Gingium, Biocur) 40 mg twice daily for 2.5 years. About 4 weeks after starting ibuprofen 600 mg daily he experienced a fatal intracerebral hemorrhage. However, the antiplatelet effects of ginkgo have been questioned. A meta-analysis and other studies have not found a significant antiplatelet effect with standardized ginkgo extracts, 80 mg to 480 mg taken daily for up to 32 weeks.
P-Glycoprotein Substrates
Theoretically, taking ginkgo with P-glycoprotein substrates might increase the levels and adverse effects of these substrates.
A small clinical study in healthy volunteers shows that using ginkgo leaf extract 120 mg orally three times daily for 14 days can increase levels of the P-glycoprotein substrate, talinolol, by 36% in healthy male individuals. However, single doses of ginkgo do not have the same effect.
Risperidone (Risperdal)
Theoretically, taking ginkgo with risperidone might increase the levels and adverse effects of risperidone.
A single case of priapism has been reported for a 26-year-old male with schizophrenia who used risperidone 3 mg daily along with ginkgo extract 160 mg daily. Risperidone is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4. CYP3A4 activity might be affected by ginkgo. Theoretically, ginkgo may inhibit the metabolism of risperidone and increase the risk of adverse effects.
Rosiglitazone (Avandia)
Theoretically, ginkgo might decrease the levels and clinical effects of rosiglitazone.
Animal research shows that ginkgo leaf extract orally 100 or 200 mg/kg daily for 10 days alters the pharmacodynamics of rosiglitazone in a dose-dependent manner. The 100 mg/kg and 200 mg/kg doses reduce the area under the concentration time curve (AUC) of rosiglitazone by 39% and 52%, respectively, and the half-life by 28% and 39%, respectively. It is hypothesized that these changes may be due to induction of cytochrome P450 2C8 by ginkgo.
Seizure Threshold Lowering Drugs
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Ginkgo seeds contain ginkgotoxin. Large amounts of ginkgotoxin can cause neurotoxicity and seizure. Ginkgotoxin is present in much larger amounts in ginkgo seeds than leaves. Ginkgo leaf extract contains trace amounts of ginkgotoxin. The amount of ginkgotoxin in ginkgo leaf and leaf extract seems unlikely to cause toxicity. However, there are anecdotal reports of seizure occurring after use of ginkgo leaf both in patients without a history of seizure disorder and in those with previously well-controlled epilepsy.
Simvastatin (Zocor)
Theoretically, ginkgo might decrease the levels and clinical effects of simvastatin.
Clinical research shows that taking ginkgo extract can reduce the area under the curve and maximum concentration of simvastatin by 32% to 39%. However, ginkgo extract does not seem to affect the cholesterol-lowering ability of simvastatin.
Sofosbuvir (Sovaldi)
Theoretically, ginkgo might increase the levels and clinical effects of sofosbuvir.
Animal research in rats shows that giving a ginkgo extract 25 mg/kg orally daily for 14 days increases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 11%, increases the half-life by 60%, and increases the plasma concentration at 4 hours by 38%. This interaction appears to be related to the inhibition of intestinal P-glycoprotein by ginkgo.
Tacrolimus (Prograf)
Theoretically, ginkgo might increase the blood levels of tacrolimus.
In vitro evidence suggests that certain biflavonoids in ginkgo leaves (i.e. amentoflavone, ginkgetin, bilobetin) may inhibit the metabolism of tacrolimus by up to 50%. This interaction appears to be time-dependent and due to inhibition of cytochrome P450 (CYP) 3A4 by these bioflavonoids. In rats given tacrolimus 1 mg/kg orally, amentoflavone was shown to increase the area under the concentration time curve (AUC) of tacrolimus by 3.8-fold.
Trazodone (Desyrel)
Theoretically, ginkgo might increase the levels and clinical effects of trazodone.
In a case report, an Alzheimer patient taking trazodone 20 mg twice daily and ginkgo leaf extract 80 mg twice daily for four doses became comatose. The coma was reversed by administration of flumazenil (Romazicon). Coma might have been induced by excessive GABA-ergic activity. Ginkgo flavonoids are thought to have GABA-ergic activity and act directly on benzodiazepine receptors. Ginkgo might also increase metabolism of trazodone to active GABA-ergic metabolites, possibly by inducing cytochrome P450 3A4 (CYP3A4) metabolism.
Warfarin (Coumadin)
Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin.
Several pharmacodynamic studies suggest that ginkgo inhibits platelet aggregation. It is thought that the ginkgo constituent, ginkgolide B, displaces platelet-activating factor (PAF) from its binding sites, decreasing blood coagulation. Several case reports have documented serious bleeding events in patients taking ginkgo. Information from a medical database suggests that when taken concurrently with warfarin, ginkgo increases the risk of a bleeding adverse event by 38%. There is also some evidence that ginkgo leaf extract can inhibit cytochrome P450 2C9, an enzyme that metabolizes warfarin. This could result in increased warfarin levels. However, population and clinical research has produced mixed results. Clinical research in healthy people suggests that ginkgo has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. A meta-analysis of 18 studies using standardized ginkgo extracts, 80 mg to 480 mg daily for up to 32 weeks, did not find a significant effect on platelet aggregation, fibrinogen concentration, or PT/aPTT. There is also some preliminary clinical research that suggests ginkgo might not significantly increase the effects of warfarin in patients that have a stable INR.
Nifedipine (Procardia)
Theoretically, taking ginkgo with oral, but not intravenous, nifedipine might increase levels and adverse effects of nifedipine.
Animal research and some clinical evidence suggests that taking ginkgo leaf extract orally in combination with oral nifedipine might increase nifedipine levels and cause increased side effects, such as headaches, dizziness, and hot flushes. However, taking ginkgo orally does not seem to affect the pharmacokinetics of intravenous nifedipine.
Omeprazole (Prilosec)
Theoretically, taking ginkgo with omeprazole might decrease the levels and clinical effects of omeprazole.
Clinical research shows that a specific ginkgo leaf extract (Remembrance, Herbs Product LTD) 140 mg twice daily can induce cytochrome P450 (CYP) 2C19 enzymes and decrease levels of omeprazole by about 27% to 42%.
Bilberry Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.
Erlotinib (Tarceva)
Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.
Zeaxanthin Carotenoid
Antidiabetes Drugs
Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.
Brand information
Manufacturer and brand details for Ginkgold Eyes 60 mg, from the product label.
Nature's Way
See all Nature's Way products- Name
- Nature's Way Brands, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 1-800-962-8873
- Web Address
- naturesway.com
Ginkgold Eyes 60 mg by Nature's Way: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Ginkgold Eyes 60 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Bilberry
Interacts with 275 drugsBilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...
Read the full Bilberry monograph → Herb & supplement monographLutein
Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...
Read the full Lutein monograph → Herb & supplement monographZeaxanthin
Interacts with 86 drugsZeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...
Read the full Zeaxanthin monograph → Herb & supplement monographGinkgo
Interacts with 1,266 drugsGinkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation. The evidence for these uses is mixed and generally weak, and it is not proven to...
Read the full Ginkgo monograph →Sources & How We Checked
Ginkgold Eyes 60 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 117 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bilberry 14 references
- Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
- Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
- Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
- Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
- Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
- Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
- Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
- Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
- Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
- Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
- Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
- Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
- Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
- Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed
Ginkgo 97 references
- Davydov L, Stirling AL. Stevens-Johnson syndrome with Ginkgo biloba. J Herb Pharmacother 2001;1:65-9. DOI
- Benjamin J, Muir T, Briggs K, Pentland B. A case of cerebral haemorrhage-can Ginkgo biloba be implicated? Postgrad Med J 2001;77:112-3.
- Matthews, MK. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology 1998;50:1934.
- Rowin J, Lewis SL. Spontaneous bilateral subdural hemotomas with chronic Ginkgo biloba ingestion. Neurology 1996;46:1775-6.
- Rosenblatt M, Mindel T. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 1997;336:1108.
- Fessenden JM, Wittenborn W, Clarke L. Gingko biloba: a case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy. Am Surg 2001;67:33-5. DOI
- Gurley BJ, Gardner SF, Hubbard MA. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. AAPS Ann Mtg & Expo Indianapolis, IN: 2000; Oct 29 - Nov 2:presentation #3460.
- Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 1998;24:139-43. PubMed
- Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol 2000;40:647-54.
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Cesarani A, Meloni F, Alpini D, et al. Ginkgo biloba (EGb 761) in the treatment of equilibrium disorders. Adv Ther 1998;15:291-304.
- Galluzzi S, Zanetti O, Binetti G, et al. Coma in a patient with Alzheimer's disease taking low dose trazodone and Ginkgo biloba. J Neurol Neurosurg Psychiatry 2000;68:679-80. DOI
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Gregory PJ. Seizure associated with Ginkgo biloba? Ann Intern Med 2001;134:344.
- Granger AS. Ginkgo biloba precipitating epileptic seizures. Age Ageing 2001;30:523-5. PubMed
- Kajiyama Y, Fujii K, Takeuchi H, Manabe Y. Ginkgo seed poisoning. Pediatrics 2002;109:325-7. PubMed
- Miwa H, Iijima M, Tanaka S, Mizuno Y. Generalized convulsions after consuming a large amount of gingko nuts. Epilepsia 2001;42:280-1. DOI
- Burschka MA, Hassan HA, Reineke T, et al. Effect of treatment with Ginkgo biloba extract EGb 761 (oral) on unilateral idiopathic sudden hearing loss in a prospective randomized double-blind study of 106 outpatients. Eur Arch Otorhinolaryngol 2001;258:213- PubMed
- Miller LG, Freeman B. Possible subdural hematoma associated with Ginkgo biloba. J Herb Pharmacother 2002;2:57-63.
- Kudolo GB, Dorsey S, Blodgett J. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. Thromb Res 2002;108:151-60.. PubMed
- Fong KC, Kinnear PE. Retrobulbar haemorrhage associated with chronic Ginkgo biloba ingestion. Postgrad Med J 2003;79:531-2..
- Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002;72:276-87.. PubMed
- Kang BJ, Lee SJ, Kim MD, Cho MJ. A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction. Hum Psychopharmacol 2002;17:279-84.
- Yale SH, Glurich I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med 2005;11:433-9.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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