No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Gluten/Dairy Digest Ingredients & Drug Interactions

by Pure Encapsulations

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Gluten/Dairy Digest is a dietary supplement by Pure Encapsulations with 3 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Gluten/Dairy Digest by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “BioCore Dairy” is listed as a grouped ingredient — the label gives one combined amount (105 mg) without saying how much of each component you get.

Gluten/Dairy Digest contains 3 active ingredients: lactase, a protease blend (Tolerase G and BioCore Dairy), and other components. Lactase is an enzyme that breaks down lactose, the natural sugar in milk and dairy products.

Protease is another enzyme that works in the digestive tract to help break down proteins. The product also contains cellulose and water as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supports gluten and dairy digestion.
  • We looked for evidence on: Lactose intolerance, Gluten sensitivity, Dairy malabsorption, Digestive enzyme insufficiency.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).

Lactase is effective for lactose intolerance. There isn't enough reliable evidence to rate its use for prematurity or colic.

Protease effectiveness ratings are not established in the data we hold, so we cannot say whether this product works for any particular condition beyond what lactase covers.

The evidence, ingredient by ingredient Lactase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated. Rarely, allergic reactions to lactase (such as contact dermatitis or allergic rhinitis and eye symptoms) have been reported in people exposed to powdered lactase, typically in occupational settings.

Protease is generally well tolerated for most adults but may occasionally cause digestive upset or allergic reactions. Because protease safety has not been established in pregnancy, it is best avoided during pregnancy unless a doctor prescribes it.

During breastfeeding, there is little safety data for protease, so talk with your doctor or pharmacist before using it. Lactase is rated likely safe during pregnancy and lactation.

For Tolerase G, we hold no safety data.

Side effects, ingredient by ingredient Lactase Proteolytic Enzymes (proteases)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented for the ingredients we could check in this product.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This product makes sense if you have trouble digesting lactose or want enzyme support for dairy and gluten-containing foods. If you're pregnant, breastfeeding, or have any history of allergic reactions to enzymes, talk with your doctor or pharmacist first — protease safety is not well established in these situations.

Check your exact medications on this page before you start, and let your doctor know you're taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gluten/Dairy Digest, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298023632
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 293966
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gluten/Dairy Digest by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
766298023632
IngredientAmount% DV
Lactase0 NP--
Tolerase G0 NP--
Protease0 NP--
BioCore Dairy105 mg--

Other ingredients: Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule as needed, with a meal, or as directed by a health care professional.

Precautions

Keep out of the reach of children.

Use only if safety seal is intact.

Tolerase G is not intended to replace a gluten-free diet. Tolerase G is not intended to treat or prevent celiac disease.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

Formulation

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Supports gluten and dairy digestion Gluten-free, non-GMO & hypoallergenic

Gluten-free, non-GMO & hypoallergenic

Seals/Symbols

GFCO.org (Gluten-Free Certification Organization)

Brand IP Statement(s)

BioCore is a trademark of National Enzyme Company. Tolerase G is a trademark of DSM.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

See for yourself

Gluten/Dairy Digest by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Gluten/Dairy Digest by Pure Encapsulations

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tolerase G

0 NP per serving Form: Prolyl Endopeptidase

BioCore Dairy

105 mg per serving

Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gluten/Dairy Digest by Pure Encapsulations Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Gluten/Dairy Digest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Gluten/Dairy Digest, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Gluten/Dairy Digest by Pure Encapsulations: Common Questions

Does Gluten/Dairy Digest by Pure Encapsulations interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Gluten/Dairy Digest. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Gluten/Dairy Digest contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lactase safe during pregnancy?
Yes — lactase is rated likely safe during pregnancy and lactation. That said, the safety information advises checking with your doctor before regular use during pregnancy, just to be sure it's right for your situation.
What's protease for?
Protease is an enzyme that helps break down proteins in your digestive tract. It's included in this product to support protein digestion alongside the lactase for dairy.
Can protease be used during pregnancy?
Safety data for protease during pregnancy is very limited, so it's best avoided unless your doctor prescribes it. Talk with your doctor or pharmacist before taking this product if you're pregnant.
Are there any known allergies to these enzymes?
Allergic reactions to lactase are rare but have been reported, mainly in people exposed to powdered lactase in occupational settings. Protease can occasionally cause allergic reactions. If you have any history of enzyme allergies, let your pharmacist know before starting.
What's Tolerase G?
Tolerase G is a blend of enzymes included in this product. We don't hold detailed interaction data for it, so if you have questions about its specific makeup or how it works, check the label or contact the manufacturer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gluten/Dairy Digest is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gluten/Dairy Digest label
Sources

Sources & How We Checked

Gluten/Dairy Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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