Glycine Ingredients & Drug Interactions
by Source Naturals
What is this page for?
First and foremost: checking Glycine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine by Source Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine by Source Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine by Source Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: glycine, a naturally occurring amino acid. Glycine plays roles in protein synthesis, nervous system function, and other metabolic processes in your body.
Does it work?
Moderate evidence
The evidence for glycine is limited and mixed. It's rated possibly effective for schizophrenia, though the data overall are lean.
For several other conditions—including 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, ADHD, benign prostatic hyperplasia (BPH), and cystic fibrosis—we don't have enough reliable evidence to say whether it works or not.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Side effects have been rare.
Mild sedation, irritability, insomnia, fatigue, memory impairment, headache, and sensory changes have been reported occasionally, though it's unclear whether glycine is truly responsible. Soft stools, nausea, vomiting, upper abdominal discomfort, and dry mouth have also been reported rarely and tend to resolve quickly if you stop taking it.
There isn't enough reliable safety data for use during pregnancy or breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril), an antipsychotic for schizophrenia, check with your doctor or pharmacist before starting glycine—it may reduce the medication's effectiveness. No other medication interactions are documented in our data for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine may be worth considering if you're interested in it for schizophrenia and your doctor approves—though the evidence is modest. If you take clozapine for schizophrenia, check with your doctor before adding this supplement, since it may interfere with how well the medication works.
For any other condition, the evidence isn't established. Talk it over with your doctor or pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine, straight from the product label.
| Brand | Source Naturals |
|---|---|
| Barcode (UPC) | 021078016045 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2017 |
| DSLD ID | 72838 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine by Source Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Glycine | 1 Gram(s) | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
500 mg
Glycine is a non-essential amino acid that has one of the simplest structures of all the amino acids. Glycine is found in proteins of all life forms, and is important in the synthesis of proteins as well as adenosine triphosphate (ATP).
Seals/Symbols
Non GMO Validated
Formulation
Non GMO Validated
Hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat.
Hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance
Suggested/Recommended/Usage/Directions
Suggested Use: 2 capsules 1 to 2 times daily.
Precautions
Caution: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
If you have kidney or liver disease or are anuric, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
SN1604 REV H151
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine by Source Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine by Source Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Glycine by Source Naturals Drug Interactions
HelloPharmacist Interaction Report
Source Naturals Glycine has a documented interaction with one medication.
The concern is with clozapine (Clozaril), an antipsychotic used for schizophrenia. A small clinical study found that adding glycine to clozapine therapy actually worsened schizophrenia symptoms compared to clozapine alone, suggesting glycine may decrease how well clozapine works.
The exact reason for this interaction isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
If you take clozapine, you'll want to check with your doctor or pharmacist before starting glycine—even though this is based on a single small study, the potential to worsen your condition is worth discussing before you add it in. Altogether, these interactions span 1 individual medication.
Use the medication checker on this page to confirm your exact medications, but if clozapine isn't one of them, the data we hold shows no documented interactions with glycine.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine, from the product label.
Source Naturals
- Name
- Source Naturals, Inc.
- Street Address
- P. O. Box 2118
- City
- Santa Cruz
- State
- CA
- ZipCode
- 95062
- Web Address
- www.sourcenaturals.com
Glycine by Source Naturals: Common Questions
Does Glycine by Source Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is glycine, and what does it do in the body?
Can I take this during pregnancy or while breastfeeding?
Does glycine actually work for schizophrenia?
What side effects might I notice?
Why does the product say to avoid it unless my doctor approves?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC