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Dietary supplement

Glycine Powder Ingredients & Drug Interactions

by Metabolic Maintenance

Glycine Powder label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glycine Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glycine Powder is a dietary supplement by Metabolic Maintenance with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glycine Powder by Metabolic Maintenance

Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine Powder by Metabolic Maintenance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glycine Powder by Metabolic Maintenance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: glycine, a simple amino acid. Glycine plays a role in protein formation and is involved in several bodily processes.

There are no inactive ingredients or fillers in this powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glycine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Glycine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Schizophrenia — rated "Possibly Effective" (Natural Medicines).

Glycine is possibly effective for schizophrenia, though we should note one clinical study showed that adding it to clozapine made symptoms worse, not better. For other conditions listed—3-phosphoglycerate dehydrogenase deficiency, ADHD, benign prostatic hyperplasia, and cystic fibrosis—there isn't enough reliable evidence in our data to rate how well it works.

Talk with your doctor about whether glycine makes sense for your specific situation.

The evidence, ingredient by ingredient Glycine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Mild sedation has rarely occurred and resolves quickly if you stop taking it.

A small number of people have reported irritability, insomnia, fatigue, memory impairment, headache, and sensory changes, though a clear link to glycine isn't certain. Digestive side effects—soft stools, nausea, vomiting, and upper stomach discomfort—have also been reported rarely and resolve when you stop.

Dry mouth has been reported, but any connection to glycine is unclear.

Side effects, ingredient by ingredient Glycine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glycine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take clozapine (Clozaril) for schizophrenia, you'll want to clear this supplement with your doctor or pharmacist first—glycine may reduce how well it works. For any other medications you're on, no interactions are documented in our data, but that's not a guarantee none exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Glycine powder is worth considering if you're exploring support for schizophrenia and your doctor agrees—just know the evidence is modest. If you take clozapine, this is a conversation you need to have with your doctor first.

Talk with your doctor or pharmacist before starting to make sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glycine Powder, straight from the product label.

Brand Metabolic Maintenance
Barcode (UPC) 838287001607
Net contents 0.5 kg; 1.1 lbs
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24866
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glycine Powder by Metabolic Maintenance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.125 tsp
Maximum serving Sizes:
0.125 tsp
Servings per container
1000
UPC/BARCODE
838287001607
IngredientAmount% DV
Glycine500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

STORAGE: Keep tightly closed in a dry place; do not expose to excessive heat.

Precautions

KEEP OUT OF THE REACH OF CHILDREN.

CAUTION: Pregnant or lactating women, consult your healthcare professional before taking this product.

Discontinue if diarrhea occurs.

General Statements

Metabolic Maintenance BULK AMINO ACIDS are guaranteed pure and have been tested and certified using current Good Manufacturing Practices.

Manufactured by GMP Certified Facility

#1118A EXP 10/12

V-01

Formulation

Excipient-free.

FDA Statement of Identity

AMINO ACID SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: 1/8 teaspoon (500mg) in 10 oz of liquid as a nutritional sweetener.

Pure glycine powder may be easily combined with water, fruit juice or other liquids.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glycine Powder by Metabolic Maintenance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glycine Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glycine Powder by Metabolic Maintenance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.125 tsp Dosage formPowder Servings per container1000 Amounts shown are per serving.

Glycine

Interacts with
1 drug
500 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions
Interaction report

Glycine Powder by Metabolic Maintenance Drug Interactions

Want to check YOUR meds against Glycine Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Glycine 1

Individual Drug Interactions

The ingredients in Glycine Powder interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Glycine Powder interact with drugs. Each result below shows which ingredient is responsible. Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glycine Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glycine Powder, from the product label.

Metabolic Maintenance

See all Metabolic Maintenance products
Name
Metabolic Maintenance Products
City
Sisters
State
Oregon
ZipCode
97759
Web Address
www.metabolicmaintenance.com
Pharmacist Counseling Corner

Glycine Powder by Metabolic Maintenance: Common Questions

Does Glycine Powder by Metabolic Maintenance interact with any medications?
Yes. Based on its ingredients, Glycine Powder has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glycine Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is glycine safe to take while pregnant or breastfeeding?
There isn't enough reliable safety data on glycine during pregnancy or while breastfeeding to know either way. Talk with your doctor or pharmacist about whether it's right for you in these situations—they can weigh the pros and cons for your individual situation.
What side effects might I notice?
Most people tolerate glycine well, but rarely some experience mild sedation, digestive upset (soft stools, nausea, vomiting, stomach discomfort), or irritability and insomnia. These usually resolve quickly if you stop. Other reported symptoms—fatigue, memory issues, headache, dry mouth—have unclear links to glycine itself.
Can glycine help with ADHD?
There isn't enough reliable evidence in our data to say whether glycine works for ADHD. Your doctor can discuss whether it's worth trying as part of your treatment plan.
How much do we know about long-term use?
Long-term safety data are limited, so we don't have a lot of information on what happens if you take it for months or years. It's generally well tolerated at typical doses, but that's an important conversation to have with your doctor if you're thinking of using it long-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glycine Powder label
Go deeper

The Full Monographs Behind Glycine Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph →
Sources

Sources & How We Checked

Glycine Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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