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Dietary supplement

Glycine Powder Ingredients & Drug Interactions

by Source Naturals

Glycine Powder label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glycine Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glycine Powder is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glycine Powder by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine Powder by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glycine Powder by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Source Naturals Glycine Powder contains one active ingredient: glycine, a simple amino acid (a building block of protein) that your body makes naturally and also gets from food. This product delivers glycine in powder form, allowing you to mix it into drinks or food.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Glycine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: protein synthesis and energy generation.
  • We looked for evidence on: Physical performance, Metabolic syndrome, Aging, ATP production, muscle protein synthesis.
  • The closest evidence on file: Glycine is rated "Insufficient Reliable Evidence To Rate" for Physical performance (Natural Medicines).
  • Also on file: Glycine is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome, Aging.

Glycine is possibly effective for schizophrenia in our data. For other uses listed — 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (BPH), and cystic fibrosis — we don't have enough reliable evidence to say whether it works.

The evidence, ingredient by ingredient Glycine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Mild sedation, irritability, insomnia, fatigue, memory impairment, headache, and sensory impairment have been reported rarely; soft stools, nausea, vomiting, upper gastrointestinal discomfort, and dry mouth have also occurred rarely — all resolve quickly if you stop taking it.

Pregnancy and breastfeeding: There isn't enough reliable safety data to know whether glycine is safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in either situation.

Side effects, ingredient by ingredient Glycine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glycine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take clozapine (Clozaril) for schizophrenia — it may reduce how well the medication works and worsen your symptoms.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you have schizophrenia or are exploring glycine for another reason and don't take clozapine, this product is generally well tolerated. If you do take clozapine, do not start this supplement without talking to your doctor first — it may make your symptoms worse.

Discuss it with your own healthcare provider to decide if it's a good fit.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glycine Powder, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078024125
Net contents 16 Ounce(s); 454 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 295744
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glycine Powder by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
454
UPC/BARCODE
021078024125
IngredientAmount% DV
Glycine, Powder1 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

For protein synthesis and energy generation

Suitable for vegetarians and hypoallergenic.

Suitable for vegetarians and hypoallergenic.

Suitable for vegetarians and hypoallergenic: contains no yeast, dairy ,egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Suggested/Recommended/Usage/Directions

Suggested Use: 1/4 teaspoon added to water, juice, or a sports drink up to two times daily on an empty stomach.

Precautions

Warning: If you are pregnant, may become pregnant, breastfeeding, have kidney or liver disease or are anuric, consult your healthcare professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formula

Glycine is an amino acid that the cells in the body may use for synthesis of protein and for adenosine triphosphate (ATP) energy generation. Source Naturals Glycine Powder can be absorbed easily when served in powder form with water, juice or when mixed in a sports supplement drink.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright Source Naturals, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glycine Powder by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glycine Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glycine Powder by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container454 Amounts shown are per serving.

Glycine, Powder

Interacts with
1 drug
1 Gram(s) per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine, Powder monograph & interactions
Interaction report

Glycine Powder by Source Naturals Drug Interactions

Want to check YOUR meds against Glycine Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Glycine, Powder 1

Individual Drug Interactions

The ingredients in Glycine Powder interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Glycine Powder interact with drugs. Each result below shows which ingredient is responsible. Glycine, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Glycine Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glycine, Powder1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glycine Powder, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Glycine Powder by Source Naturals: Common Questions

Does Glycine Powder by Source Naturals interact with any medications?
Yes. Based on its ingredients, Glycine Powder has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glycine Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is glycine and what does it do?
Glycine is an amino acid your body makes naturally and obtains from protein-containing foods. This powder form lets you take it as a supplement, though we have solid evidence it works only for schizophrenia (where it's possibly effective) — for most other conditions, the evidence isn't established.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough reliable safety data to know if glycine is safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist before starting it in either situation — they can help you decide what's best for you and your baby.
What side effects might I notice?
Mild sedation, irritability, insomnia, and headache have been reported rarely. Mild stomach issues like soft stools, nausea, or upper GI discomfort are also uncommon. These typically go away quickly once you stop taking it.
Is this safe to take long-term?
Glycine is generally well tolerated at typical doses, but we don't have enough long-term safety data to be certain about indefinite use. If you're considering it long-term, talk with your doctor or pharmacist first.
Why does the bottle say there aren't enough data about safety?
Because glycine hasn't been studied as extensively as some other supplements, especially over long periods and in certain groups like pregnant or breastfeeding people. That doesn't mean it's unsafe — just that we need more information to be fully sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glycine Powder label
Go deeper

The Full Monographs Behind Glycine Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph →
Sources

Sources & How We Checked

Glycine Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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