GM-H3 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking GM-H3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
GM-H3 is a dietary supplement by Loomis Enzymes with 12 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of GM-H3 by Loomis Enzymes
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
GM-H3 contains 12 active digestive enzymes. The main ones we can identify are protease (breaks down protein), lipase (breaks down fat), lactase (breaks down milk sugar), and several others including amylase, cellulase, invertase, glucoamylase, alpha-galactosidase, superoxide dismutase, hemicellulase, diastase, and acid maltase.
The formula also includes two proprietary enzyme blends — the Proprietary Plant Enzyme Blend and BioCore DPP-IV — whose exact makeup isn't disclosed on the label. The capsule itself is vegetable-based, and phytase is listed as an inactive ingredient.
Does it work?
Couldn't assess
Lactase in this product is rated effective for lactose intolerance. For the other digestive enzymes, the evidence isn't established in our data — lipase has insufficient evidence for inflammatory bowel disease, dyspepsia, and prematurity, and lactase shows insufficient evidence for colic and prematurity.
We hold no effectiveness ratings for the remaining ingredients.
How safe is it?
Well-documented data
Protease is generally well tolerated in most adults, but it may cause digestive upset or allergic reactions in some people. Safety data during pregnancy is limited, so it's best avoided during pregnancy unless prescribed; there's also little data during breastfeeding, so medical advice is recommended.
Lipase is generally well tolerated in supplement form, but people with serious digestive conditions should use it only under medical guidance. There is little safety data on supplemental lipase in pregnancy or breastfeeding — talk with your doctor before using it during either.
Lactase is generally well tolerated and rated likely safe in pregnancy; it acts only in the gut, so breastfeeding risk is low, though checking with your doctor first is wise. A rare case of allergic contact dermatitis and allergic rhinoconjunctivitis from occupational lactase exposure has been reported.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check in GM-H3. That said, we couldn't verify several enzymes in the formula, so ask your doctor or pharmacist to confirm it's compatible with your specific medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
GM-H3 is a broad-spectrum digestive enzyme formula. It's a reasonable choice if you're looking to support general digestion, especially if you're lactose intolerant — lactase is the one ingredient here with solid evidence.
Be cautious if you have serious digestive problems (talk to your doctor first), and if you're pregnant or breastfeeding, check with your doctor or pharmacist before starting it. Run it through the interaction checker on this page to confirm it's okay with any medications you take.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about GM-H3, straight from the product label.
| Brand | Loomis Enzymes |
|---|---|
| Barcode (UPC) | 697706013108 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 22, 2021 |
| DSLD ID | 246577 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for GM-H3 by Loomis Enzymes, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Superoxide Dismutase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Diastase | 0 NP | -- |
| Proprietary Plant Enzyme Blend | 322 mg | -- |
| Acid Maltase | 0 NP | -- |
| BioCore DPP-IV | 80 mg | -- |
Other ingredients: Vegetable Capsule, Phytase
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
pHBS pH Balancing System
BioCore DPP-IV is a registered trademark of Deerland Probiotics and Enzymes
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Keep out of reach of children
Note: Consult your physician before using this product if you are pregnant, nursing, taking medication, or have a medical condition.
Do not use if inner or outer seal is broken, torn, or missing.
Storage
To ensure freshness and potency, keep bottle tightly closed and store in a cool, dry place.
FDA Statement of Identity
A Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for Use: Take 1 capsule, 3 times daily with meals or as directed.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
GM-H3 by Loomis Enzymes label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in GM-H3 by Loomis Enzymes
These are the 12 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Plant Enzyme Blend
BioCore DPP-IV
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
BioCore DPP-IV monograph & interactions- › Protease
Other (inactive) ingredients: Vegetable Capsule, Phytase. These complete the product’s ingredient list but are not active constituents.
GM-H3 by Loomis Enzymes Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in GM-H3. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for GM-H3, from the product label.
Loomis Enzymes
See all Loomis Enzymes products- Name
- Loomis Enzymes, LLC
- City
- Madison
- State
- Wisconsin
- ZipCode
- 53719
- Phone Number
- 1-800-614-4400
- Web Address
- www.loomisenzymes.com
GM-H3 by Loomis Enzymes: Common Questions
Does GM-H3 by Loomis Enzymes interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will GM-H3 help my lactose intolerance?
Is it safe to take GM-H3 while pregnant?
Can I use GM-H3 while breastfeeding?
What does this enzyme blend do?
Are there any common side effects?
Why can't I see what's in the proprietary blends?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if GM-H3 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind GM-H3’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph →Sources & How We Checked
GM-H3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC