Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Grass-Fed Beef Liver 4500 mg Ingredients & Drug Interactions

by Wholesome Wellness

Grass-Fed Beef Liver 4500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Grass-Fed Beef Liver 4500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Grass-Fed Beef Liver 4500 mg is a dietary supplement by Wholesome Wellness with 1 active ingredient. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Beef Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Grass-Fed Beef Liver 4500 mg by Wholesome Wellness

Ask about any prescription or over-the-counter medication and we check it for interactions with Grass-Fed Beef Liver 4500 mg by Wholesome Wellness — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Grass-Fed Beef Liver 4500 mg by Wholesome Wellness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is a single-ingredient supplement: beef liver in capsule form at 4500 mg per dose. The capsules themselves contain gelatin as an inactive ingredient.

Beef liver is a whole-food source of nutrients, including heme iron and fat-soluble vitamins like vitamin A — both present in amounts higher than you'd typically get from eating liver.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Promotes healthy skin, hair, nails, joints and gums.
  • We looked for evidence on: skin health, hair health, nail health, joint health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for beef liver in treating chronic fatigue syndrome (CFS) is rated possibly ineffective — meaning studies haven't shown it works for that use. For hepatitis C, there isn't enough reliable evidence to rate it one way or the other.

The data we hold doesn't cover other claimed uses.

The evidence, ingredient by ingredient Liver Extract

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beef liver is generally well tolerated in food amounts, but this concentrated form delivers high levels of vitamin A and iron, which warrant caution. There's also a sourcing concern: liver extract comes from raw animal livers from slaughterhouses, which could theoretically carry contamination — including bovine spongiform encephalitis (BSE), the cause of mad cow disease — if sourced from affected countries.

While no human cases of BSE from liver extract products have been reported, the risk isn't zero. Pregnancy and lactation carry particular concern because of the high vitamin A content, which may harm a developing baby.

The product safety notes advise against it in pregnancy unless your doctor advises otherwise. A thorough safety evaluation hasn't been completed, so talk with your doctor or pharmacist before using, especially if you're pregnant, breastfeeding, or have iron-overload concerns.

Side effects, ingredient by ingredient Liver Extract

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Liver Extract.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on warfarin (Coumadin), a blood thinner, talk to your pharmacist — beef liver's vitamin K content could theoretically weaken the drug's effect. If you take iron medications or supplements, also check first, since adding beef liver could push your iron intake too high, especially over time.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Beef liver supplements are a whole-food option for someone looking for concentrated nutrients, but they're not proven to treat fatigue or hepatitis C. If you take warfarin or iron supplements, check with your pharmacist first.

Pregnant folks and those with iron-storage disorders should talk to their doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Grass-Fed Beef Liver 4500 mg, straight from the product label.

Brand Wholesome Wellness
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 271508
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Grass-Fed Beef Liver 4500 mg by Wholesome Wellness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
IngredientAmount% DV
Beef Liver4500 mg, 3000 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

This powerful potent super food is rich with vitamin A, B12, CoQ10, zinc, copper, folate, choline and hyaluronic acid. How can this help benefit & nourish your body? Promotes healthy skin, hair, nails, teeth and gum. Supports strong joints, connective tissue and healthy collagen. Promotes strong immune and digestive system. Supports good energy, mood and metabolism. Supports brain, heart and liver health.

Grass-Fed Beef Liver 750 mg per capsule

Grass-fed liver is the most nutrient rich organ part of the animal and has been consumed by our native ancestors for thousands of years for its super food benefits. It is nature's most concentrated source of vitamin A and our ancestors wasted no part of the animal, with liver being the most valued part of traditional diets due to its nutrient density and ability to rejuvenate the body. Over time, we have lost touch with this powerful healing super food until now... Our premium product line is always grass-fed pasture-raised fully inspected from head to tail, born & raised without use of hormones, antibiotics, or pesticides.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Tell Us What Your Think Have a question? Not happy with the product? Please email us and we will make it right.

Our commitment to exceptional quality never ends

Servings Per Container 45-30

Formulation

Max potency

Max potency Pasture raised Grass-fed & fully inspected Made with the highest standards GMP certified - 3rd party tested

Packaged and quality tested in the USA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 4-6 capsules daily or as directed by a healthcare professional

Seals/Symbols

Manufactured in an FDA Registered Facility

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Grass-Fed Beef Liver 4500 mg by Wholesome Wellness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Grass-Fed Beef Liver 4500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Grass-Fed Beef Liver 4500 mg by Wholesome Wellness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Beef Liver

Interacts with
3 drugs
4500 mg per serving

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...

Beef Liver monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Grass-Fed Beef Liver 4500 mg by Wholesome Wellness Drug Interactions

Want to check YOUR meds against Grass-Fed Beef Liver 4500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Beef Liver 3

Individual Drug Interactions

The ingredients in Grass-Fed Beef Liver 4500 mg interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in Grass-Fed Beef Liver 4500 mg interact with drugs. Each result below shows which ingredient is responsible. Beef Liver

Each ingredient & the kinds of drugs it affects

For each ingredient in Grass-Fed Beef Liver 4500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beef Liver2 drug types · 3 drugs

Iron

Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.

Likelihood Possible Evidence C
Beef Liver full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Grass-Fed Beef Liver 4500 mg, from the product label.

Wholesome Wellness

See all Wholesome Wellness products
Name
Wholesome Wellness
Street Address
6804 NE 79th Court #527708
City
Portland
State
Oregon
ZipCode
97218
Web Address
http://wholesome-wellness.com
Pharmacist Counseling Corner

Grass-Fed Beef Liver 4500 mg by Wholesome Wellness: Common Questions

Does Grass-Fed Beef Liver 4500 mg by Wholesome Wellness interact with any medications?
Yes. Based on its ingredients, Grass-Fed Beef Liver 4500 mg has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Grass-Fed Beef Liver 4500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it in pregnancy because beef liver is very high in vitamin A, which can harm a developing baby. There isn't enough data on safety during breastfeeding. Talk with your doctor or pharmacist before using if you're pregnant or nursing.
Is this beef liver really grass-fed, and does it matter for safety?
We can't verify the grass-fed claim from the product facts. What we do know is that all beef liver extract carries sourcing concerns — it comes from raw animal livers gathered from slaughterhouses and could theoretically be contaminated if sourced from countries where bovine spongiform encephalitis (mad cow disease) has been reported.
Will this help my chronic fatigue?
The evidence shows beef liver is possibly ineffective for chronic fatigue syndrome, so studies haven't found it works for that use. It's not a proven treatment.
What's the vitamin A and iron concern about?
This concentrated beef liver supplement delivers high levels of both vitamin A and iron — much more than you'd get from eating liver as food. In large amounts or over a long time, either can cause problems, especially if you're already getting iron from other sources or have a condition that makes you store too much iron.
Are there any reported side effects from this product?
No adverse reactions have been formally reported. However, a complete safety evaluation hasn't been done, so side effects aren't ruled out — especially with long-term use or high doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Grass-Fed Beef Liver 4500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Grass-Fed Beef Liver 4500 mg label
Go deeper

The Full Monographs Behind Grass-Fed Beef Liver 4500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Liver Extract

Interacts with 3 drugs

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before pu...

Read the full Liver Extract monograph →
Sources

Sources & How We Checked

Grass-Fed Beef Liver 4500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Liver Extract 4 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

See these in context on the Liver Extract monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team