Graviola Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Graviola Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola Extract is a dietary supplement by Indiana Botanic Gardens with 2 active ingredients. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola 4:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola Extract by Indiana Botanic Gardens
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola Extract by Indiana Botanic Gardens — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Graviola Extract by Indiana Botanic Gardens
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients. The main one is Graviola 4:1 extract — a concentrated form of graviola fruit traditionally used in herbal medicine.
The other ingredient listed is Other Carbohydrates; we hold no interaction data for it. The capsule also contains inactive ingredients: maltodextrin, gelatin, rice flour, and vegetable magnesium stearate — these are fillers and binders that hold the supplement together.
Does it work?
Couldn't assess
The evidence for graviola's effectiveness isn't established in our data. We have insufficient reliable evidence to rate it for human papillomavirus (HPV), headache, use as an insect repellent, or male infertility.
If you're considering it for one of these purposes, talk with your doctor about whether the evidence supports it and what other options might work better.
How safe is it?
Well-documented data
Human safety data for graviola are limited, and there are concerns about possible nerve toxicity with long-term use. The most common side effects reported are stomach pain and nausea.
Rarely, people have experienced movement disorders or nerve damage (myeloneuropathy) — symptoms that can resemble Parkinson disease. One study even suggests that regular consumption of graviola may worsen motor and cognitive symptoms in people with Parkinson disease.
Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding because there isn't enough safety information. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) for seizures, this product may reduce how well it works — a Moderate concern. Check with your doctor or pharmacist before combining them.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola Extract may be worth discussing with your doctor if you're interested in it for a specific health purpose — but the evidence for its effectiveness isn't well established. The bigger concern is that it can lower seizure-medicine levels if you take carbamazepine, and long-term use raises questions about nerve safety.
If you're pregnant, breastfeeding, or have Parkinson disease, steer clear. Check with your doctor or pharmacist before starting, especially if you take any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola Extract, straight from the product label.
| Brand | Indiana Botanic Gardens |
|---|---|
| Barcode (UPC) | 703308020595 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 25, 2013 |
| DSLD ID | 27599 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola Extract by Indiana Botanic Gardens, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 {Calories} | 1% |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Other Carbohydrates | 1 Gram(s) | -- |
| Graviola 4:1 extract | 1 Gram(s) | -- |
Other ingredients: Maltodextrin, Gelatin, Rice Flour, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1-2 capsules daily, as a dietary supplement, or as directed by a physician.
Precautions
Warning: If you are taking any medications or are pregnant or nursing do not use prior to consulting a physician.
For your protection, this container has an outer safety seal. (Do not accept if missing or broken.)
KEEP OUT OF REACH OF CHILDREN
General Statements
Best if used by date on bottle.
Stress Support
Storage
Store in a dry, cool place.
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
IBG INDIANA BOTANIC GARDENS(R)
FDA Disclaimer Statement
This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola Extract by Indiana Botanic Gardens label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola Extract by Indiana Botanic Gardens
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other Carbohydrates
Graviola 4:1 extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola 4:1 extract monograph & interactionsOther (inactive) ingredients: Maltodextrin, Gelatin, Rice Flour, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Graviola Extract by Indiana Botanic Gardens Drug Interactions
HelloPharmacist Interaction Report
Graviola Extract by Indiana Botanic Gardens interacts with one medication: carbamazepine (Tegretol), a seizure medicine.
The concern is Moderate in severity — graviola may lower how much carbamazepine your body absorbs and uses, which could make the drug less effective at controlling seizures. A rat study found that graviola reduced carbamazepine levels by roughly one-third to one-half.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, talk with your doctor or pharmacist before starting this product. We could not check the other ingredient, Other Carbohydrates, because we hold no data for it.
You can search your exact medications in the tool on this page to see if any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola Extract interact with 1 drug. Click any drug to see the details.
1 of the 2 ingredients in Graviola Extract interact with drugs. Each result below shows which ingredient is responsible. Graviola 4:1 extract
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola Extract — through 1 ingredient. Tap an ingredient for the detail:
Graviola 4:1 ExtractCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola 4:1 Extract + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola 4:1 extract
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola Extract, from the product label.
Graviola Extract by Indiana Botanic Gardens: Common Questions
Does Graviola Extract by Indiana Botanic Gardens interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Does graviola work for HPV, headaches, or insect repellent?
Is this safe to use long-term?
What's a 4:1 extract?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC