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Dietary supplement

Graviola (Soursop) 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Graviola (Soursop) 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Graviola (Soursop) 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Graviola (Soursop) 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Graviola (Soursop) 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola (Soursop) 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Graviola (Soursop) 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: graviola (soursop), 450 mg per capsule. The capsules also hold gelatin and water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Graviola product and its label doesn't state a use — see Graviola's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that graviola works for any condition. Studies on human papillomavirus (HPV), headache, male infertility, and insect repellent all show insufficient reliable evidence to rate whether it's effective.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's what you need to know: regular use of graviola may not be safe. The most common side effects reported in a trial were nausea and burning pain in the upper belly after taking 300 mg daily.

Rare but serious concerns include movement disorders and nerve damage (myeloneuropathy) that can resemble Parkinson disease symptoms. One large study in Parkinson patients found that even small amounts of graviola fruit, juice, or herbal tea worsened their movement and thinking problems.

Long-term use also raises lab concerns about possible nerve toxicity, though human safety data remain limited. Graviola is not advised during pregnancy or breastfeeding — there isn't enough safety data to say it's okay, so the advice is to avoid it in both situations.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol), a seizure medication, check with your pharmacist first — graviola may lower how well it works. No other interactions are documented in our data for this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Unless you have a specific reason supported by your doctor, graviola isn't the strongest choice. The evidence it works for anything is thin, and safety concerns around nerve problems and movement issues are real.

If you take carbamazepine for seizures, definitely check with your pharmacist before using it. Talk to us before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Graviola (Soursop) 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064434282593
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 285867
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Graviola (Soursop) 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064434282593
IngredientAmount% DV
Graviola450 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Graviola (Soursop) 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Graviola (Soursop) 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Graviola (Soursop) 450 mg by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Graviola

Interacts with
1 drug
450 mg per serving Form: Soursop

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Graviola (Soursop) 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Graviola (Soursop) 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Graviola 1

Individual Drug Interactions

The ingredients in Graviola (Soursop) 450 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Graviola (Soursop) 450 mg interact with drugs. Each result below shows which ingredient is responsible. Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Graviola (Soursop) 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Graviola (Soursop) 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Graviola (Soursop) 450 mg by TerraVita Premium Collection: Common Questions

Does Graviola (Soursop) 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Graviola (Soursop) 450 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Graviola (Soursop) 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — graviola isn't advised during pregnancy or breastfeeding. The safety data aren't there, so the recommendation is to avoid it in both situations. Talk with your doctor or pharmacist if you're thinking about it.
What are the side effects?
The most common ones are nausea and burning pain in the upper belly. Rare but serious concerns include movement disorders and nerve damage that can look like Parkinson disease. One study found that even small amounts worsened Parkinson symptoms in affected patients.
Does graviola actually work for HPV, headaches, or infertility?
The evidence we hold doesn't establish that it works for any of those. The data on human papillomavirus, headache, male infertility, and insect repellent all show insufficient reliable evidence.
Is it safe to take long-term?
Regular use may not be safe. Lab studies raise concerns about possible nerve toxicity with long-term use, and human safety data are limited. This isn't a supplement to take indefinitely without talking to your pharmacist first.
I take a seizure medication. Is graviola okay?
No — if you take carbamazepine (Tegretol), graviola may lower how well it works. A rat study showed it can reduce carbamazepine levels by 35–46%. Talk with your doctor or pharmacist before using this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Graviola (Soursop) 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Graviola (Soursop) 450 mg label
Go deeper

The Full Monographs Behind Graviola (Soursop) 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Graviola (Soursop) 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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