Green Lipped Mussel 500 mg Ingredients & Drug Interactions
by Swanson
What is this page for?
First and foremost: checking Green Lipped Mussel 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Green Lipped Mussel 500 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis symptoms, joint stiffness and mobility.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Green Lipped Mussel 500 mg by Swanson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has one active ingredient: freeze-dried Green Lipped Mussel at 500 mg per capsule. The supplement also contains inactive ingredients (gelatin, microcrystalline cellulose, magnesium stearate, and silica) that make up the capsule and help with storage and absorption.
Does it work?
Not established
The evidence for Green Lipped Mussel is thin across the board. We have insufficient reliable evidence to rate it for asthma, attention deficit-hyperactivity disorder (ADHD), breast cancer, or exercise-induced muscle soreness.
That doesn't mean it doesn't work—it means the studies we have aren't strong enough yet to say either way.
How safe is it?
Well-documented data
Green Lipped Mussel is generally well tolerated orally. The most common side effects are mild and digestive: abdominal pain, acid reflux, diarrhea, flatulence, and nausea.
Rare cases of liver inflammation (hepatitis) and liver function abnormalities have been reported with a specific mussel extract called Seatone, so if you develop yellowing of the skin or eyes, dark urine, or unexplained abdominal pain, stop and see your doctor. If you have a shellfish allergy, avoid this product.
The safety data during pregnancy advises against use, and there isn't enough information to know whether it's safe while breastfeeding—talk with your doctor or pharmacist before taking it if either applies to you.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Still, run your exact medications through the checker on this page before you start, or ask your pharmacist to confirm.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Green Lipped Mussel might be worth considering if you're curious about its potential for joint or athletic recovery, but the evidence backing those uses isn't solid yet. Anyone with a shellfish allergy should steer clear.
If you're pregnant, breastfeeding, or have liver concerns, check with your pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Green Lipped Mussel 500 mg, straight from the product label.
| Brand | Swanson |
|---|---|
| Barcode (UPC) | 087614114347 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 266913 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Green Lipped Mussel 500 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| freeze-dried Green Lipped Mussel | 500 mg | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
swanson.com or call 1-800-437-4148
Science-Backed Quality Since 1969
Formulation
Supports joint comfort and mobility Whole food consisting of chondroitin sulfate, minerals and other nutrients for joint health
Joint Health and Mobility
Sourced from New Zealand
500 mg per capsule
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take one capsule per day with water.
Precautions
Warning: For adults only.
Do not take this product if you are pregnant or nursing. Consult your healthcare provider before using this or any product if you are taking medication or have a medical condition.
Keep out of reach of children.
Do not use if seal is broken.
Contains shellfish (green lipped mussel).
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Green Lipped Mussel 500 mg by Swanson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Green Lipped Mussel 500 mg by Swanson
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Freeze-dried Green Lipped Mussel
No knowninteractions
New Zealand green-lipped mussel is a shellfish-derived supplement rich in omega-3 fats that is mostly used for joint pain and arthritis. Some studies...
Freeze-dried Green Lipped Mussel monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Green Lipped Mussel 500 mg by Swanson Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Green Lipped Mussel 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Green Lipped Mussel 500 mg, from the product label.
Swanson
See all Swanson products- Name
- Swanson Health Products
- City
- Fargo
- State
- ND
- ZipCode
- 58104
- Phone Number
- 1-800-437-4148
- Web Address
- swanson.com
Green Lipped Mussel 500 mg by Swanson: Common Questions
Does Green Lipped Mussel 500 mg by Swanson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I have a shellfish allergy?
Is it safe to take while pregnant or breastfeeding?
What are the most common side effects?
Does Green Lipped Mussel work for joint health or sore muscles?
Are there any fillers in this capsule?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Green Lipped Mussel 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Green Lipped Mussel 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Green Lipped Mussel 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
New Zealand Green-lipped Mussel 12 references
- Miller T, Wu H. In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J 1984;97:355-7.
- Gibson SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial. Complement Ther Med 1998;6:122-6.
- Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980;224:955-60.
- Fabrin, B. [Possible toxic hepatitis after intake of an alternative preparation]. Ugeskr.Laeger 6-13-1988;150(24):1474-1475.
- Gibson, R. G. and Gibson, S. L. Green-lipped mussel extract in arthritis. Lancet 2-21-1981;1(8217):439. PubMed
- Ahern, M. J., Milazzo, S. C., and Dymock, R. Granulomatous hepatitis and Seatone. Med J Aust 8-9-1980;2(3):151-152. PubMed
- Croft, J. E. Granulomatous hepatitis and Seatone. Med J Aust 10-4-1980;2(7):401-402. PubMed
- Lau, S., Chiu, P. K., Chu, E. M. Y., Cheng, I. Y. W., Tang, W. M., Man, R. Y. K., and Halpern, G. M. Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study. Progress in Nutrition
- Gruenwald, J., Graubaum, H., Hansen, K., and Grube, B. Efficacy and tolerability of a combination of LYPRINOL and high concentrations of EPA and DHA in inflammatory rheumatoid disorders... eicosapentaenoic acid... decosahexaenoid acid. Advances in Therap PubMed
- Coulson S, Vecchio P, Gramotnev H, Vitetta L. Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study. Inflammopharmacology 2012;20:71-6. PubMed
- Sukumaran S, Pittman KB, Patterson WK, et al. A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer. Ann Oncol 2010;2 PubMed
- Lello J, Liang A, Robinson E, et al. Treatment of children's asthma with a lipid extract of the new Zealand green lipped mussel (Perna canaliculus) (Lyprinol®)-A double blind, randomized controlled trial in children with moderate to serve chronic obstruct
See these in context on the New Zealand Green-lipped Mussel monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC