Green Lipped Mussel Powder Ingredients & Drug Interactions
by XtendLife
What is this page for?
First and foremost: checking Green Lipped Mussel Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Green Lipped Mussel Powder is a dietary supplement by XtendLife with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis symptoms, joint stiffness and mobility.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Green Lipped Mussel Powder by XtendLife
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: green-lipped mussel powder, which is derived from a type of mussel native to New Zealand. The capsules also contain inactive ingredients including hydroxypropyl methylcellulose (a capsule material), water, and rosemary leaf extract.
Does it work?
Not established
The evidence for green-lipped mussel is limited. Our data rates it as having insufficient reliable evidence to support its use for asthma, ADHD, breast cancer, and exercise-induced muscle soreness.
If you're considering this supplement for any of these conditions, talk with your doctor about whether it's a good fit for you.
How safe is it?
Well-documented data
Green-lipped mussel is generally well tolerated. The most common side effects are stomach-related — abdominal pain, acid reflux, diarrhea, flatulence, and nausea.
Rare cases of hepatitis (liver inflammation) have been reported with a specific mussel extract called Seatone, so if you develop yellowing of the skin or eyes, dark urine, or severe abdominal pain, stop taking it and see your doctor right away. If you have a shellfish allergy, avoid this product entirely.
The safety data advises against use during pregnancy, and there isn't enough data to know if it's safe while breastfeeding — talk with your doctor or pharmacist for personalized guidance on either.
Meds to double-check
No known interactions
No interactions are documented for green-lipped mussel in our data. That doesn't mean none exist, so mention this supplement to your pharmacist when you pick up your medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Green-lipped mussel powder is generally well tolerated but has limited evidence for the conditions it's marketed for. If you have a shellfish allergy or are pregnant or breastfeeding, skip it.
Otherwise, check with your pharmacist first — especially if you have any liver concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Green Lipped Mussel Powder, straight from the product label.
| Brand | XtendLife |
|---|---|
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2023 |
| DSLD ID | 283358 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Green Lipped Mussel Powder by XtendLife, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Protein | 2 Gram(s) | 4% |
| Green Lipped Mussel powder | 2400 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Water, Rosemary Leaf Extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions for use Take 4 capsules per day, anytime, with or after food.
Formulation
Xtend-Life Green Lipped Mussel Powder supports healthy joint function, and provides nutritional support for skin and connective tissues.
Does not contain soy, dairy, gluten or peanut.
Vegetarian capsules
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Formula
Specialty nutrients
Xtend-Life Green Lipped Mussel Powder is a natural product from selected mussels cultured in the pristine waters of the Marlborough Sounds, in New Zealand. To ensure optimal benefits, these unique mussels are processed at low temperatures while fresh to ensure that all of the valuable fractions of the mussels are preserved. The Green Lipped Mussel (Perna canaliculus) is a species found nowhere else in the world. An environmental focus and strict regulations enable us to deliver a product of exceptional quality. Green Lipped Mussels are an exceptional whole-food, packed with valuable nutrients.
Seals/Symbols
Best Quality Guarantee
Precautions
Contains shellfish (mussel).
General Statements
NewZealand.com Licence No.100055
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Green Lipped Mussel Powder by XtendLife label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Green Lipped Mussel Powder by XtendLife
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Green Lipped Mussel powder
No knowninteractions
New Zealand green-lipped mussel is a shellfish-derived supplement rich in omega-3 fats that is mostly used for joint pain and arthritis. Some studies...
Green Lipped Mussel powder monograph & interactionsOther (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Rosemary Leaf Extract. These complete the product’s ingredient list but are not active constituents.
Green Lipped Mussel Powder by XtendLife Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Green Lipped Mussel Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Green Lipped Mussel Powder, from the product label.
XtendLife
- Phone Number
- 1-888-487-9304
Green Lipped Mussel Powder by XtendLife: Common Questions
Does Green Lipped Mussel Powder by XtendLife interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this bother my stomach?
Can I take it if I'm allergic to shellfish?
Is this safe during pregnancy?
Can I take it while breastfeeding?
Does this actually work for what it claims?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Green Lipped Mussel Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Green Lipped Mussel Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Green Lipped Mussel Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
New Zealand Green-lipped Mussel 12 references
- Miller T, Wu H. In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J 1984;97:355-7.
- Gibson SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial. Complement Ther Med 1998;6:122-6.
- Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980;224:955-60.
- Fabrin, B. [Possible toxic hepatitis after intake of an alternative preparation]. Ugeskr.Laeger 6-13-1988;150(24):1474-1475.
- Gibson, R. G. and Gibson, S. L. Green-lipped mussel extract in arthritis. Lancet 2-21-1981;1(8217):439. PubMed
- Ahern, M. J., Milazzo, S. C., and Dymock, R. Granulomatous hepatitis and Seatone. Med J Aust 8-9-1980;2(3):151-152. PubMed
- Croft, J. E. Granulomatous hepatitis and Seatone. Med J Aust 10-4-1980;2(7):401-402. PubMed
- Lau, S., Chiu, P. K., Chu, E. M. Y., Cheng, I. Y. W., Tang, W. M., Man, R. Y. K., and Halpern, G. M. Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study. Progress in Nutrition
- Gruenwald, J., Graubaum, H., Hansen, K., and Grube, B. Efficacy and tolerability of a combination of LYPRINOL and high concentrations of EPA and DHA in inflammatory rheumatoid disorders... eicosapentaenoic acid... decosahexaenoid acid. Advances in Therap PubMed
- Coulson S, Vecchio P, Gramotnev H, Vitetta L. Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study. Inflammopharmacology 2012;20:71-6. PubMed
- Sukumaran S, Pittman KB, Patterson WK, et al. A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer. Ann Oncol 2010;2 PubMed
- Lello J, Liang A, Robinson E, et al. Treatment of children's asthma with a lipid extract of the new Zealand green lipped mussel (Perna canaliculus) (Lyprinol®)-A double blind, randomized controlled trial in children with moderate to serve chronic obstruct
See these in context on the New Zealand Green-lipped Mussel monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC